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William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
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Journal ArticleDOI
Papillomavirus E7 Oncoproteins Share Functions with Polyomavirus Small T Antigens
Elizabeth A. White,Rebecca Kramer,Justin H. Hwang,Arun T. Pores Fernando,Nana Naetar,William C. Hahn,Thomas M. Roberts,Brian Schaffhausen,David M. Livingston,Peter M. Howley +9 more
TL;DR: Several new functions for the papillomavirus E7 proteins are reported, which will contribute new insights into the roles of viruses in cancer and the cellular pathways they perturb in carcinogenesis.
Journal ArticleDOI
A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines
Mehmet Gönen,Mehmet Gönen,Barbara A. Weir,Glenn S. Cowley,Glenn S. Cowley,Francisca Vazquez,Francisca Vazquez,Yuanfang Guan,Alok Jaiswal,Masayuki Karasuyama,Vladislav Uzunangelov,Tao Wang,Aviad Tsherniak,Sara Howell,Sara Howell,Daniel Marbach,Daniel Marbach,Bruce Hoff,Thea Norman,Antti Airola,Adrian Bivol,Kerstin Bunte,Kerstin Bunte,Daniel E. Carlin,Sahil Chopra,Sahil Chopra,Alden Deran,Kyle Ellrott,Kyle Ellrott,Peddinti Gopalacharyulu,Kiley Graim,Samuel Kaski,Samuel Kaski,Suleiman A. Khan,Yulia Newton,Sam Ng,Tapio Pahikkala,Evan O. Paull,Artem Sokolov,Hao Tang,Jing Tang,Krister Wennerberg,Yang Xie,Xiaowei Zhan,Zhu Fan,Bahman Afsari,Tero Aittokallio,Tero Aittokallio,Jesse S. Boehm,Yu Chuan Chang,Tenghui Chen,Zechen Chong,Haitham Elmarakeby,Elana J. Fertig,Emanuel Gonçalves,Pinghua Gong,Christoph Hafemeister,William C. Hahn,William C. Hahn,Lenwood S. Heath,Łukasz Kędziorski,Niraj Khemka,Erh kan King,Mario Lauria,Mark Liu,Daniel Machado,Hiroshi Mamitsuka,Adam A. Margolin,Mateusz Mazurkiewicz,Michael P. Menden,Szymon Migacz,Zhi Nie,Paurush Praveen,Corrado Priami,Simone Rizzetto,Miguel Rocha,David E. Root,Cameron Rudd,Witold R. Rudnicki,Julio Saez-Rodriguez,Lei Song,Gustavo Stolovitzky,Gustavo Stolovitzky,Joshua M. Stuart,Duanchen Sun,Bence Szalai,Difei Wang,Ling-Yun Wu,Guanghua Xiao,Jieping Ye,Yuting Ye,Wanding Zhou +91 more
TL;DR: This study establishes benchmarks for gene essentiality prediction, presents a community resource for future comparison with this benchmark, and provides insights into factors influencing the ability to predict gene essentiality from functional genetic screens.
Journal ArticleDOI
Functional Genomic Characterization of Cancer Genomes.
Thomas P. Howard,Francisca Vazquez,Francisca Vazquez,Aviad Tsherniak,Andrew L. Hong,Andrew L. Hong,Andrew L. Hong,Mik Rinne,Mik Rinne,Andrew J. Aguirre,Andrew J. Aguirre,Jesse S. Boehm,William C. Hahn,William C. Hahn +13 more
TL;DR: This work has developed several approaches to systematically interrogate genomic changes found in human tumors and taken an unbiased approach to identify genes that are essential for cancer cell proliferation or survival in cell lines that are extensively annotated to identify context-specific essential genes.
Journal ArticleDOI
Cancer genomics: integrating form and function
TL;DR: This review focuses on recent advances in the application of genomic strategies to the study of cancer, with an emphasis on functional genomics and the prospects for integrating the knowledge gained from these approaches to further develop the understanding of cancer and design better therapeutic strategies.
Journal ArticleDOI
Integrative functional genomics identifies RINT1 as a novel GBM oncogene
Steven N. Quayle,Milan G. Chheda,Sachet A. Shukla,Sachet A. Shukla,Ruprecht Wiedemeyer,Pablo Tamayo,Robert W. Dewan,Li Zhuang,Emmet Huang-Hobbs,Sam Haidar,Yonghong Xiao,Yonghong Xiao,Keith L. Ligon,Keith L. Ligon,William C. Hahn,William C. Hahn,Lynda Chin +16 more
TL;DR: The feasibility and potential of in vitro functional genomic screens to rapidly and systematically prioritize high-probability candidate genes for in vivo validation are demonstrated and RINT1 was validated as a novel GBM oncogene based on its ability to confer tumorigenicity to primary nontransformed murine astrocytes in vivo.