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William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
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Journal ArticleDOI
In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissues.
Atac Baykal,Jennifer Anne Thompson,Xiao-Chun Xu,William C. Hahn,Michael T. Deavers,Anais Malpica,David M. Gershenson,Elvio G. Silva,Jinsong Liu +8 more
TL;DR: It is concluded that human telomerase reverse transcriptase mRNA expression does not seem to be a reliable marker for clinical use in differentiating between benign and malignant tumors.
Journal ArticleDOI
Bladder cancer: modeling and translation
TL;DR: An elegant genetically engineered murine model of bladder cancer is described that recapitulates many of the cardinal features of the human disease and provides a unique opportunity for innovative translational studies.
Journal ArticleDOI
Liprin alpha1 interacts with PP2A B56gamma.
TL;DR: A novel role forPP2A B56γ independent of its regulation of PP2A activity is suggested, as suppression of liprin α1 by RNA interference alters cell morphology.
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Transformation-Dependent Silencing of Tumor-Selective Apoptosis-Inducing TRAIL by DNA Hypermethylation Is Antagonized by Decitabine
Per Lund,Irina Kotova,Valerie Kedinger,Harshal Khanwalkar,Emilie Voltz,William C. Hahn,Hinrich Gronemeyer +6 more
TL;DR: The results emphasize the potential of decitabine to enhance TRAIL-induced apoptosis in tumors and thus provide a rationale for combination therapies with decitABine to increase tumor-selective apoptosis.
Posted ContentDOI
Predicting cell health phenotypes using image-based morphology profiling
Gregory P. Way,Maria Kost-Alimova,Tsukasa Shibue,William F. Harrington,Stanley Gill,Stanley Gill,Federica Piccioni,Federica Piccioni,Tim Becker,William C. Hahn,William C. Hahn,Anne E. Carpenter,Francisca Vazquez,Shantanu Singh +13 more
TL;DR: It is found that simple machine learning algorithms can predict many cell health readouts directly from Cell Painting images, at less than half the cost, and can be used to add cell health annotations to Cell Painting perturbation datasets.