William C. Hahn

TL;DR: CERES, a computational method to estimate gene dependency levels from CRISPR-Cas9 essentiality screens while accounting for the copy-number-specific effect, as well as variable sgRNA activity, is developed and applied to sets of screens performed with different sgRNAs and found that it reduces false positive results and provides meaningful estimates of sg RNA activity.

TL;DR: This Commentary is an invitation to an open discussion started among various users of RNAi to set forth accepted standards that would insure the quality and accuracy of information in the large datasets coming out of genome-scale screens.

TL;DR: In this paper, whole-exome sequencing of circulating tumor cells enables accurate and powered calling of somatic point mutations, and the authors propose a method to identify the source of the point mutations.

TL;DR: Three cases of inadvertent injection of sodium hypochlorite and hydrogen peroxide beyond the root apex are presented and clinical symptoms are discussed, as well as preventive and therapeutic considerations.

TL;DR: It is shown through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit only minimal AKT activation and a diminished reliance on AKT for anchorage-independent growth.