W
William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
Papers
More filters
Journal ArticleDOI
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Priscilla K. Brastianos,Scott L. Carter,Scott L. Carter,Sandro Santagata,Sandro Santagata,Daniel P. Cahill,Amaro Taylor-Weiner,Robert T. Jones,Eliezer M. Van Allen,Eliezer M. Van Allen,Michael S. Lawrence,Peleg M. Horowitz,Kristian Cibulskis,Keith L. Ligon,Keith L. Ligon,Josep Tabernero,Joan Seoane,Elena Martínez-Sáez,William T. Curry,Ian F. Dunn,Sun Ha Paek,Sung Hye Park,Aaron McKenna,Aaron Chevalier,Mara Rosenberg,Fred G. Barker,Corey M. Gill,Paul Van Hummelen,Aaron R. Thorner,Bruce E. Johnson,Mai P. Hoang,Toni K. Choueiri,Sabina Signoretti,Carrie Sougnez,Michael S. Rabin,Nan Lin,Eric P. Winer,Anat Stemmer-Rachamimov,Matthew Meyerson,Levi A. Garraway,Levi A. Garraway,Stacey Gabriel,Eric S. Lander,Rameen Beroukhim,Rameen Beroukhim,Tracy T. Batchelor,José Baselga,David N. Louis,Gad Getz,Gad Getz,William C. Hahn,William C. Hahn +51 more
TL;DR: Stricker et al. as discussed by the authors performed whole-exome sequencing of 86 matched brain metastases, primary tumors, and normal tissue and found potentially clinically informative alterations in the brain metastasis not detected in the matched primary-tumor sample.
Journal ArticleDOI
Organoid Modeling of the Tumor Immune Microenvironment.
James T. Neal,Xingnan Li,Junjie Zhu,Valeria Giangarra,Caitlin L. Grzeskowiak,Jihang Ju,Iris H. Liu,Shin Heng Chiou,Ameen A. Salahudeen,Amber R. Smith,Brian C. Deutsch,Lillian Liao,Allison Zemek,Fan Zhao,Kasper Karlsson,Liora M. Schultz,Thomas J. Metzner,Lincoln Nadauld,Yuen-Yi Tseng,Sahar Alkhairy,Coyin Oh,Paula Keskula,Daniel Mendoza-Villanueva,Francisco M. De La Vega,Pamela L. Kunz,Joseph C. Liao,John T. Leppert,John B. Sunwoo,Chiara Sabatti,Jesse S. Boehm,William C. Hahn,William C. Hahn,Grace X.Y. Zheng,Mark M. Davis,Mark M. Davis,Calvin J. Kuo +35 more
TL;DR: Air-liquid interface method propagated patient-derived organoids (PDOs) from >100 human biopsies or mouse tumors in syngeneic immunocompetent hosts as tumor epithelia with native embedded immune cells to enable immuno-oncology investigations within the TME and facilitate personalized immunotherapy testing.
Journal ArticleDOI
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
Elizabeth S. Yeh,Melissa Cunningham,Hugh Arnold,Dawn Chasse,Teresa Monteith,Giovanni Ivaldi,William C. Hahn,P. Todd Stukenberg,Shirish Shenolikar,Takafumi Uchida,Christopher M. Counter,Joseph R. Nevins,Anthony R. Means,Rosalie C. Sears +13 more
TL;DR: It is shown that Ser 62 is dephosphorylated by protein phosphatase 2A (PP2A) before ubiquitination of c-Myc, and that PP2A activity is regulated by the Pin1 prolyl isomerase, resulting in c- myc stabilization.
Journal ArticleDOI
Telomerase maintains telomere structure in normal human cells.
Kenkichi Masutomi,Evan Y. Yu,Shilagardy Khurts,Ittai Ben-Porath,Jennifer L. Currier,Geoffrey B. Metz,Mary W. Brooks,Shuichi Kaneko,Seishi Murakami,James A. DeCaprio,Robert A. Weinberg,Sheila A. Stewart,William C. Hahn +12 more
TL;DR: The view that telomerase and telomere structure are dynamically regulated in normal human cells and that telomeres length alone is unlikely to trigger entry into replicative senescence is supported.
Journal ArticleDOI
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
Christopher M. Counter,William C. Hahn,Wenyi Wei,Stephanie Dickinson Caddle,Roderick L. Beijersbergen,Peter M. Lansdorp,John M. Sedivy,Robert A. Weinberg +7 more
TL;DR: It is shown that ectopic expression of the telomerase catalytic subunit (human telomersase reverse transcriptase or hTERT) and subsequent activation of telomer enzyme can allow postsenescent cells to proliferate beyond crisis, the last known proliferative blockade to cellular immortality.