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William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
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Journal ArticleDOI
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells
Brian Elenbaas,Lisa Spirio,Frederick C. Koerner,Mark D. Fleming,Drazen B. Zimonjic,Joana Liu Donaher,Nicholas C. Popescu,William C. Hahn,Robert A. Weinberg +8 more
TL;DR: It is shown that introduction of three genes encoding the SV40 large-T antigen, the telomerase catalytic subunit, and an H-Ras oncoprotein into primary HMECs results in cells that form tumors when transplanted subcutaneously or into the mammary glands of immunocompromised mice.
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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
Adam J. Bass,Adam J. Bass,Hideo Watanabe,Hideo Watanabe,Craig H. Mermel,Craig H. Mermel,Soyoung Yu,Sven Perner,Sven Perner,Roeland Verhaak,Roeland Verhaak,So Young Kim,Leslie Wardwell,Pablo Tamayo,Irit Gat-Viks,Alex H. Ramos,Alex H. Ramos,Michele S. Woo,Michele S. Woo,Barbara A. Weir,Barbara A. Weir,Gad Getz,Rameen Beroukhim,Rameen Beroukhim,Michael O'Kelly,Amit Dutt,Amit Dutt,Orit Rozenblatt-Rosen,Piotr Dziunycz,Justin Komisarof,Lucian R. Chirieac,Christopher J. LaFargue,Veit Scheble,Theresia Wilbertz,Changqing Ma,Shilpa Rao,Hiroshi Nakagawa,Douglas B. Stairs,Lin Lin,Thomas J. Giordano,Patrick L. Wagner,John D. Minna,Adi F. Gazdar,Chang-Qi Zhu,Marcia S. Brose,Ivan Cecconello,Ulysses Ribeiro,Suely Kazue Nagahashi Marie,Olav Dahl,Ramesh A. Shivdasani,Ming-Sound Tsao,Mark A. Rubin,Kwok K. Wong,Aviv Regev,William C. Hahn,William C. Hahn,David G. Beer,Anil K. Rustgi,Matthew Meyerson,Matthew Meyerson +59 more
TL;DR: A peak of genomic amplification on chromosome 3q26.33 found in squamous cell carcinomas of the lung and esophagus contains the transcription factor gene SOX2, which is necessary for normal esophageal squamous development, promotes differentiation and proliferation of basal tracheal cells and cooperates in induction of pluripotent stem cells.
Journal ArticleDOI
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Susan Bullman,Susan Bullman,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Ewa Sicinska,Thomas E. Clancy,Xiaoyang Zhang,Xiaoyang Zhang,Diana Cai,Diana Cai,Donna Neuberg,Katherine H. Huang,Fatima Guevara,Timothy Nelson,Otari Chipashvili,Timothy Hagan,Mark Walker,Aruna Ramachandran,Aruna Ramachandran,Begoña Diosdado,Begoña Diosdado,Garazi Serna,Nuria Mulet,Stefania Landolfi,Santiago Ramón y Cajal,Roberta Fasani,Andrew J. Aguirre,Andrew J. Aguirre,Andrew J. Aguirre,Kimmie Ng,Elena Elez,Shuji Ogino,Shuji Ogino,Josep Tabernero,Charles S. Fuchs,William C. Hahn,William C. Hahn,William C. Hahn,Paolo Nuciforo,Matthew Meyerson,Matthew Meyerson,Matthew Meyerson +41 more
TL;DR: Col colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors.
Journal ArticleDOI
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
Sonam Dolma,Stephen L. Lessnick,Stephen L. Lessnick,William C. Hahn,William C. Hahn,Brent R. Stockwell +5 more
TL;DR: It is found that overexpressing hTERT and either E7 or LT increased expression of topoisomerase 2alpha and that overeXpressing RAS(V12) and ST both increased expressionof topoisomersase 1 and sensitized cells to a nonapoptotic cell death process initiated by erastin.
Journal ArticleDOI
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Lauren L. C. Marotta,Vanessa Almendro,Vanessa Almendro,Andriy Marusyk,Michail Shipitsin,Janina Schemme,Sarah R. Walker,Noga Bloushtain-Qimron,Jessica J. Kim,Sibgat Choudhury,Reo Maruyama,Zhenhua Wu,Mithat Gonen,Laura Mulvey,Marina Bessarabova,Sung Jin Huh,Serena J. Silver,So Young Kim,So Young Kim,So Yeon Park,Hee Eun Lee,Karen S. Anderson,Andrea L. Richardson,Tatiana Nikolskaya,Yuri Nikolsky,X. Shirley Liu,David E. Root,William C. Hahn,William C. Hahn,David A. Frank,Kornelia Polyak +30 more
TL;DR: The IL-6/JAK2/Stat3 pathway was preferentially active in CD44+CD24- breast cancer cells compared with other tumor cell types, and inhibition of JAK2 decreased their number and blocked growth of xenografts.