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Wing-Pui Kong
Researcher at National Institutes of Health
Publications - 55
Citations - 4815
Wing-Pui Kong is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Vaccination & Virus. The author has an hindex of 20, co-authored 55 publications receiving 3752 citations. Previous affiliations of Wing-Pui Kong include Vaccine Research Center & Government of the United States of America.
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Journal ArticleDOI
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Jesper Pallesen,Nianshuang Wang,Kizzmekia S. Corbett,Daniel Wrapp,Robert N. Kirchdoerfer,Hannah L. Turner,Christopher A. Cottrell,Michelle M. Becker,Lingshu Wang,Wei Shi,Wing-Pui Kong,Erica L. Andres,Arminja N. Kettenbach,Mark R. Denison,Mark R. Denison,James D. Chappell,Barney S. Graham,Andrew B. Ward,Jason S. McLellan +18 more
TL;DR: An engineering strategy for stabilization of soluble S proteins in the prefusion conformation is described, which results in greatly increased expression, conformational homogeneity, and elicitation of potent antibody responses, and an engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV.
Journal ArticleDOI
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates.
Kizzmekia S. Corbett,Barbara J. Flynn,Kathryn E. Foulds,Joseph R. Francica,Seyhan Boyoglu-Barnum,Anne P. Werner,Britta Flach,Sarah O’Connell,Kevin W. Bock,Mahnaz Minai,Bianca M. Nagata,Hanne Leth Andersen,David R. Martinez,Amy T. Noe,Naomi Douek,Mitzi M. Donaldson,Nadesh N Nji,Gabriela S. Alvarado,Darin K. Edwards,Dillon R. Flebbe,Evan Lamb,Nicole A. Doria-Rose,Bob C. Lin,Mark K. Louder,Sijy O'Dell,Stephen D. Schmidt,Emily Phung,Lauren A. Chang,Christina Yap,John-Paul Todd,Laurent Pessaint,Alex Van Ry,Shanai Browne,Jack Greenhouse,Tammy Putman-Taylor,Amanda Strasbaugh,Tracey-Ann Campbell,Anthony Cook,Alan Dodson,Katelyn Steingrebe,Wei Shi,Yi Zhang,Olubukola M. Abiona,Lingshu Wang,Amarendra Pegu,Eun Sung Yang,Kwanyee Leung,Tongqing Zhou,I-Ting Teng,Alicia T. Widge,Ingelise J. Gordon,Laura Novik,Rebecca A. Gillespie,Rebecca J. Loomis,Juan I. Moliva,Guillaume Stewart-Jones,Sunny Himansu,Wing-Pui Kong,Martha Nason,Kaitlyn M. Morabito,Tracy J. Ruckwardt,Julie E. Ledgerwood,Martin R. Gaudinski,Peter D. Kwong,John R. Mascola,Andrea Carfi,Mark G. Lewis,Ralph S. Baric,Adrian B. McDermott,Ian N. Moore,Nancy J. Sullivan,Mario Roederer,Robert A. Seder,Barney S. Graham +73 more
TL;DR: Vaccination of nonhuman primates with mRNA-1273 induced robust SARS-CoV-2 neutralizing activity, rapid protection in the upper and lower airways, and no pathologic changes in the lung.
Journal ArticleDOI
p53 inhibition by the LANA protein of KSHV protects against cell death.
TL;DR: LANA interacts with the tumour suppressor protein p53 and represses its transcriptional activity, which contributes to viral persistence and oncogenesis in KS through its ability to promote cell survival by altering p53 function.
Journal ArticleDOI
Rapid development of a DNA vaccine for Zika virus
Kimberly A. Dowd,Sung-Youl Ko,Kaitlyn M. Morabito,Eun Sung Yang,Rebecca S. Pelc,Christina R. DeMaso,Leda R. Castilho,Leda R. Castilho,Peter Abbink,Michael R. Boyd,Ramya Nityanandam,David N. Gordon,John R. Gallagher,Xuejun Chen,John-Paul Todd,Yaroslav Tsybovsky,Audray K. Harris,Yan-Jang S. Huang,Stephen Higgs,Dana L. Vanlandingham,Hanne Andersen,Mark G. Lewis,Rafael De La Barrera,Kenneth H. Eckels,Richard G. Jarman,Martha Nason,Dan H. Barouch,Mario Roederer,Wing-Pui Kong,John R. Mascola,Theodore C. Pierson,Barney S. Graham +31 more
TL;DR: It is found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZikV challenge correlated with serum neutralizing activity.
Journal ArticleDOI
Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses
M. Gordon Joyce,Adam K. Wheatley,Paul V. Thomas,Gwo-Yu Chuang,Cinque Soto,Robert T. Bailer,Aliaksandr Druz,Ivelin S. Georgiev,Ivelin S. Georgiev,Ivelin S. Georgiev,Rebecca A. Gillespie,Masaru Kanekiyo,Wing-Pui Kong,Kwanyee Leung,Sandeep N. Narpala,Madhu Prabhakaran,Eun Sung Yang,Baoshan Zhang,Yi Zhang,Mangaiarkarasi Asokan,Jeffrey C. Boyington,Tatsiana Bylund,Sam Darko,Christopher R. Lees,Amy Ransier,Chen-Hsiang Shen,Lingshu Wang,James R R Whittle,Xueling Wu,Hadi M. Yassine,Celia Santos,Yumiko Matsuoka,Yaroslav Tsybovsky,Ulrich Baxa,James C. Mullikin,Kanta Subbarao,Daniel C. Douek,Barney S. Graham,Richard A. Koup,Julie E. Ledgerwood,Mario Roederer,Lawrence Shapiro,Lawrence Shapiro,Peter D. Kwong,John R. Mascola,Adrian B. McDermott +45 more
TL;DR: Vaccination with a divergent hemagglutinin can increase the frequency of B cells encoding broad influenza A-neutralizing antibodies, and this work proposes the sequence signature-quantified prevalence of these B cells as a metric to guide universal influenza A immunization strategies.