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Wolfgang Weninger
Researcher at Medical University of Vienna
Publications - 362
Citations - 25279
Wolfgang Weninger is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Cytotoxic T cell & Immune system. The author has an hindex of 72, co-authored 325 publications receiving 21882 citations. Previous affiliations of Wolfgang Weninger include University of Pennsylvania & Royal Prince Alfred Hospital.
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Journal ArticleDOI
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Kandice R. Levental,Hongmei Yu,Laura Kass,Johnathon N. Lakins,Mikala Egeblad,Janine T. Erler,Sheri F. T. Fong,Katalin Csiszar,Amato J. Giaccia,Wolfgang Weninger,Mitsuo Yamauchi,David L. Gasser,Valerie M. Weaver +12 more
TL;DR: Reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence, and data show how collagenCrosslinking can modulate tissue fibrosis and stiffness to force focal adhesion, growth factor signaling and breast malignancies.
Journal ArticleDOI
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
J. Rodrigo Mora,María Rosa Bono,N. Manjunath,Wolfgang Weninger,Lois L. Cavanagh,Mario Rosemblatt,Ulrich H. von Andrian +6 more
TL;DR: It is established that Peyer's patch dendritic cells imprint gut-homing specificity on T cells, and thus license effector/memory cells to access anatomical sites most likely to contain their cognate antigen.
Journal ArticleDOI
Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries: Podoplanin as a Specific Marker for Lymphatic Endothelium
Silvana Breiteneder-Geleff,Afschin Soleiman,Heinrich Kowalski,Reinhard Horvat,Gabriele Amann,Ernst Kriehuber,Katja Diem,Wolfgang Weninger,Erwin Tschachler,Kari Alitalo,Dontscho Kerjaschki +10 more
TL;DR: In this article, a light and electron microscopic immunohistochemistry (EMI) was used to detect podoplanin, a ∼38kd membrane glycoprotein of podocytes, specifically expressed in the endothelium of lymphatic capillaries, but not in the blood vasculature.
Journal ArticleDOI
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson,Ann M. Flenniken,Xiao Ji,Lydia Teboul,Michael D. Wong,Jacqueline K. White,Terrence F. Meehan,Wolfgang Weninger,Henrik Westerberg,Hibret A. Adissu,Candice N. Baker,Lynette Bower,James M. Brown,L. Brianna Caddle,Francesco Chiani,Dave Clary,James Cleak,Mark J. Daly,James M. Denegre,Brendan Doe,Mary E. Dolan,Sarah M. Edie,Helmut Fuchs,Valerie Gailus-Durner,Antonella Galli,Alessia Gambadoro,Juan Gallegos,Shiying Guo,Neil R. Horner,Chih-Wei Hsu,Sara Johnson,Sowmya Kalaga,Lance C. Keith,Louise Lanoue,Thomas N. Lawson,Monkol Lek,Monkol Lek,Manuel Mark,Susan Marschall,Jeremy Mason,Melissa L. McElwee,Susan Newbigging,Lauryl M. J. Nutter,Kevin A. Peterson,Ramiro Ramirez-Solis,Douglas J. Rowland,Edward Ryder,Kaitlin E. Samocha,Kaitlin E. Samocha,John R. Seavitt,Mohammed Selloum,Zsombor Szoke-Kovacs,Masaru Tamura,Amanda G. Trainor,Ilinca Tudose,Shigeharu Wakana,Jonathan Warren,Olivia Wendling,David B. West,Leeyean Wong,Atsushi Yoshiki,Daniel G. MacArthur,Daniel G. MacArthur,Glauco P. Tocchini-Valentini,Xiang Gao,Paul Flicek,Allan Bradley,William C. Skarnes,Monica J. Justice,Helen Parkinson,Mark W. Moore,Sara Wells,Robert E. Braun,Karen L. Svenson,Martin Hrabé de Angelis,Yann Herault,Timothy J. Mohun,Ann-Marie Mallon,R. Mark Henkelman,Steve D.M. Brown,David J. Adams,Kevin C K Lloyd,Colin McKerlie,Arthur L. Beaudet,Maja Bucan,Stephen A. Murray +85 more
TL;DR: It is shown that human disease genes are enriched for essential genes, thus providing a dataset that facilitates the prioritization and validation of mutations identified in clinical sequencing efforts and reveals that incomplete penetrance and variable expressivity are common even on a defined genetic background.
Journal ArticleDOI
Asymmetric T lymphocyte division in the initiation of adaptive immune responses.
John T. Chang,Vikram R. Palanivel,Ichiko Kinjyo,Felix Schambach,Andrew M. Intlekofer,Arnob Banerjee,Sarah A. Longworth,Kristine E. Vinup,Paul Mrass,Jane Oliaro,Nigel Killeen,Jordan S. Orange,Sarah M. Russell,Sarah M. Russell,Wolfgang Weninger,Steven L. Reiner +15 more
TL;DR: It is shown that a dividing T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division, suggesting a mechanism by which a single lymphocyte can apportion diverse cell fates necessary for adaptive immunity.