R
Richard Barfield
Researcher at Fred Hutchinson Cancer Research Center
Publications - 37
Citations - 1440
Richard Barfield is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Medicine & Genome-wide association study. The author has an hindex of 12, co-authored 26 publications receiving 1032 citations. Previous affiliations of Richard Barfield include University of Washington & Harvard University.
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Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Brian M. Wolpin,Cosmeri Rizzato,Peter Kraft,Charles Kooperberg,Gloria M. Petersen,Zhaoming Wang,Alan A. Arslan,Laura Beane-Freeman,Paige M. Bracci,Julie E. Buring,Federico Canzian,Eric J. Duell,Steven Gallinger,Graham G. Giles,Gary E. Goodman,Phyllis J. Goodman,Eric J. Jacobs,Aruna Kamineni,Alison P. Klein,Laurence N. Kolonel,Matthew H. Kulke,Donghui Li,Núria Malats,Sara H. Olson,Harvey A. Risch,Howard D. Sesso,Howard D. Sesso,Kala Visvanathan,Emily White,Emily White,Wei Zheng,Christian C. Abnet,Demetrius Albanes,Gabriella Andreotti,Melissa A. Austin,Richard Barfield,Daniela Basso,Sonja I. Berndt,Marie-Christine Boutron-Ruault,Michelle Brotzman,Markus W. Büchler,H. Bas Bueno-de-Mesquita,Peter Bugert,Laurie Burdette,Daniele Campa,Neil E. Caporaso,Gabriele Capurso,Charles C. Chung,Michelle Cotterchio,Eithne Costello,Joanne W. Elena,Niccola Funel,J. Michael Gaziano,J. Michael Gaziano,J. Michael Gaziano,Nathalia Giese,Edward Giovannucci,Michael Goggins,Megan J. Gorman,Myron D. Gross,Christopher A. Haiman,Manal M. Hassan,Kathy J. Helzlsouer,Brian E. Henderson,Elizabeth A. Holly,Nan Hu,David J. Hunter,Federico Innocenti,Mazda Jenab,Rudolf Kaaks,Timothy J. Key,Kay-Tee Khaw,Eric A. Klein,Manolis Kogevinas,Vittorio Krogh,Juozas Kupcinskas,Robert C. Kurtz,Andrea Z. LaCroix,Maria Teresa Landi,Stefano Landi,Loic Le Marchand,Andrea Mambrini,Satu Männistö,Roger L. Milne,Yusuke Nakamura,Ann L. Oberg,Kouros Owzar,Alpa V. Patel,Petra H.M. Peeters,Petra H.M. Peeters,Ulrike Peters,Raffaele Pezzilli,Ada Piepoli,Miquel Porta,Miquel Porta,Francisco X. Real,Francisco X. Real,Elio Riboli,Nathaniel Rothman,Aldo Scarpa,Xiao-Ou Shu,Debra T. Silverman,Pavel Soucek,Malin Sund,Renata Talar-Wojnarowska,Philip R. Taylor,George Theodoropoulos,Mark D. Thornquist,Anne Tjønneland,Geoffrey S. Tobias,Dimitrios Trichopoulos,Pavel Vodicka,Jean Wactawski-Wende,Nicolas Wentzensen,Chen Wu,Herbert Yu,Kai Yu,Anne Zeleniuch-Jacquotte,Robert N. Hoover,Patricia Hartge,Charles S. Fuchs,Stephen J. Chanock,Rachael S. Stolzenberg-Solomon,Laufey T. Amundadottir +123 more
TL;DR: This study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies and an independent signal in exon 2 of TERT at the established region 5p15.
Journal ArticleDOI
Accounting for Population Stratification in DNA Methylation Studies
Richard Barfield,Lynn M. Almli,Varun Kilaru,Alicia K. Smith,Kristina B. Mercer,Richard Duncan,Torsten Klengel,Divya Mehta,Elisabeth B. Binder,Michael P. Epstein,Kerry J. Ressler,Karen N. Conneely +11 more
TL;DR: Among the different approaches to computing methylation‐based PCs, it is found that PCs based on CpG sites chosen for their potential to proxy nearby SNPs can provide a powerful and computationally efficient approach to adjust for population stratification in DNA methylation studies when genome‐wide SNP data are unavailable.
Journal ArticleDOI
CpGassoc: an R function for analysis of DNA methylation microarray data
TL;DR: CpGassoc is a modular, expandable package with functions to perform rapid analyses of DNA methylation data via fixed or mixed effects models, to perform basic quality control, to carry out permutation tests, and to display results via an array of publication-quality plots.
Journal ArticleDOI
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
Lang Wu,Wei Shi,Jirong Long,Xingyi Guo,Kyriaki Michailidou,Kyriaki Michailidou,Jonathan Beesley,Manjeet K. Bolla,Xiao-Ou Shu,Yingchang Lu,Qiuyin Cai,Fares Al-Ejeh,E Rozali,Qin Wang,Joe Dennis,Bingshan Li,Chenjie Zeng,Helian Feng,Alexander Gusev,Richard Barfield,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Kristan J. Aronson,Paul L. Auer,Paul L. Auer,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Javier Benitez,Marina Bermisheva,Carl Blomqvist,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Louise A. Brinton,Per Broberg,Sara Y. Brucker,Barbara Burwinkel,Barbara Burwinkel,Trinidad Caldés,Federico Canzian,Brian D. Carter,J. Esteban Castelao,Jenny Chang-Claude,Jenny Chang-Claude,Xiaoqing Chen,Tongguang Cheng,Hans Christiansen,Christine L. Clarke,Margriet Collée,Sten Cornelissen,Fergus J. Couch,David Cox,David Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Miriam Dwek,Diana Eccles,Ursula Eilber,A. Heather Eliassen,Christoph Engel,Mikael Eriksson,Laura Fachal,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Marike Gabrielson,Manuela Gago-Dominguez,Susan M. Gapstur,Montserrat Garcia-Closas,Mia M. Gaudet,Maya Ghoussaini,Graham G. Giles,Graham G. Giles,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Pascal Guénel,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Per Hall,Emily Hallberg,Ute Hamann,Patricia Harrington,Alexander Hein,Belynda Hicks,Peter Hillemanns,Antoinette Hollestelle,Robert N. Hoover,John L. Hopper,Guanmengqian Huang,Keith Humphreys,David J. Hunter,David J. Hunter,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Audrey Y. Jung,Rudolf Kaaks,Michael J. Kerin,Elza Khusnutdinova,Elza Khusnutdinova,Veli-Matti Kosma,Vessela N. Kristensen,Diether Lambrechts,Loic Le Marchand,Jingmei Li,Sara Lindström,Sara Lindström,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jan Lubinski,Craig Luccarini,Michael P. Lux,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Ivana Maleva Kostovska,Ivana Maleva Kostovska,Arto Mannermaa,JoAnn E. Manson,Sara Margolin,Dimitrios Mavroudis,Hanne Meijers-Heijboer,Alfons Meindl,Usha Menon,J.-P. Meyer,Anna Marie Mulligan,Anna Marie Mulligan,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Børge G. Nordestgaard,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Paolo Peterlongo,Julian Peto,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gad Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Atocha Romero,Jane Romm,Anja Rudolph,Emmanouil Saloustros,Dale P. Sandler,Elinor J. Sawyer,Marjanka K. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Mitul Shah,Martha J. Shrubsole,Ann Smeets,Melissa C. Southey,John J. Spinelli,Jennifer Stone,Jennifer Stone,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,William J. Tapper,Jack A. Taylor,Mary Beth Terry,Daniel C. Tessier,Abigail Thomas,Kathrin Thöne,Rob A. E. M. Tollenaar,Diana Torres,Diana Torres,Thérèse Truong,Michael Untch,Celine M. Vachon,David Van Den Berg,Daniel Vincent,Quinten Waisfisz,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Lucy Xia,Xiaohong R. Yang,Argyrios Ziogas,Elad Ziv,Alison M. Dunning,Paul D.P. Pharoah,Jacques Simard,Roger L. Milne,Roger L. Milne,Stacey L. Edwards,Peter Kraft,Douglas F. Easton,Georgia Chenevix-Trench,Wei Zheng +234 more
TL;DR: A transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci at loci not yet reported for breast cancer.
Journal ArticleDOI
Transcriptome‐wide association studies accounting for colocalization using Egger regression
Richard Barfield,Helian Feng,Alexander Gusev,Alexander Gusev,Lang Wu,Wei Zheng,Bogdan Pasaniuc,Peter Kraft +7 more
TL;DR: An extension of the Mendelian randomization (MR) egger regression method is examined that allows for LD while only requiring summary association data for both GWAS and eQTL, to distinguish between true susceptibility genes and colocalization due to LD.