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Ying-Jie Wang
Researcher at Zhejiang University
Publications - 56
Citations - 2759
Ying-Jie Wang is an academic researcher from Zhejiang University. The author has contributed to research in topics: Induced pluripotent stem cell & Phosphatidylinositol. The author has an hindex of 24, co-authored 51 publications receiving 2414 citations. Previous affiliations of Ying-Jie Wang include Flinders University & Merck & Co..
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Journal ArticleDOI
Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi
Ying-Jie Wang,Jing Wang,Hui Qiao Sun,Manuel Martinez,Yu Xiao Sun,Eric Macia,Tomas Kirchhausen,Joseph P. Albanesi,Michael G. Roth,Helen L. Yin +9 more
TL;DR: It is proposed that PI4KIIalpha establishes the Golgi's unique lipid-defined organelle identity by generating PI(4)P-rich domains that specify the docking of the AP-1 coat machinery.
Journal ArticleDOI
Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency
Paolo Ingallinella,Elisabetta Bianchi,Neal A. Ladwa,Ying-Jie Wang,Renee Hrin,Maria Veneziano,Fabio Bonelli,Thomas J. Ketas,John P. Moore,Michael D. Miller,Antonello Pessi +10 more
TL;DR: C34 derivatized with cholesterol (C34- Chol) shows dramatically increased antiviral potency on a panel of primary isolates, with IC90 values 15- to 300-fold lower than enfuvirtide and the second-generation inhibitor T1249, making C34-Chol the most potent HIV fusion inhibitor to date.
Journal ArticleDOI
Reciprocal Regulation of Akt and Oct4 Promotes the Self-Renewal and Survival of Embryonal Carcinoma Cells
Yuanji Lin,Ying Yang,Weihua Li,Qi Chen,Jie Li,Xiao Pan,Lina Zhou,Changwei Liu,Changwei Liu,Chunsong Chen,Jianqin He,Hongcui Cao,Hangping Yao,Li Zheng,Xiaowei Xu,Zongping Xia,Jiangtao Ren,Lei Xiao,Lanjuan Li,Binghui Shen,Binghui Shen,Honglin Zhou,Ying-Jie Wang +22 more
TL;DR: A site-specific, posttranslational modification of the Oct4 protein orchestrates the regulation of its stability, subcellular localization, and transcriptional activities, which collectively promotes the survival and tumorigenicity of ECCs.
Journal ArticleDOI
O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth.
Xiongjian Rao,Xiaotao Duan,Weimin Mao,Xuexia Li,Zhonghua Li,Qian Li,Zhiguo Zheng,Haimiao Xu,Min Chen,Peng George Wang,Peng George Wang,Ying-Jie Wang,Binghui Shen,Wen Yi +13 more
TL;DR: It is shown that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the PPP, is dynamically modified with an O-linked β-N-acetylglucosamine sugar in response to hypoxia, revealing a mechanistic understanding of how O-glycosylation directly regulates the P PP to confer a selective growth advantage to tumours.
Journal ArticleDOI
Phosphatidylinositol phosphate 5-kinase Iβ recruits AP-2 to the plasma membrane and regulates rates of constitutive endocytosis
TL;DR: The results indicate that constitutive endocytosis in CV-1 and HeLa cells requires (and may be regulated by) PIP2 produced primarily by PIP5KIβ, and the number of clathrin-coated pits at the plasma membrane increased when PIP 2 increased.