Z
Zélia Gouveia
Researcher at Instituto Gulbenkian de Ciência
Publications - 6
Citations - 236
Zélia Gouveia is an academic researcher from Instituto Gulbenkian de Ciência. The author has contributed to research in topics: Heme & Endoplasmic reticulum. The author has an hindex of 5, co-authored 5 publications receiving 179 citations. Previous affiliations of Zélia Gouveia include Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa.
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Journal ArticleDOI
Heme cytotoxicity and the pathogenesis of immune-mediated inflammatory diseases.
TL;DR: Targeting “free heme” may be used as a therapeutic intervention against diseases related to oxidative stress and immune-mediated inflammatory conditions.
Journal ArticleDOI
Renal control of disease tolerance to malaria.
Susana Ramos,Ana Rita Carlos,Balamurugan Sundaram,Viktória Jeney,Ana Ribeiro,Raffaella Gozzelino,Claudia Bank,Erida Gjini,Faouzi Braza,Rui Martins,Temitope W. Ademolue,Birte Blankenhaus,Zélia Gouveia,Pedro Faísca,Damian L. Trujillo,Silvia Cardoso,Sofia Rebelo,Laura del Barrio,Abolfazl Zarjou,Subhashini Bolisetty,Anupam Agarwal,Anupam Agarwal,Miguel P. Soares +22 more
TL;DR: It is demonstrated that the establishment of disease tolerance to malaria relies on a tissue damage-control mechanism that operates specifically in renal proximal tubule epithelial cells (RPTEC), which relies on the induction of heme oxygenase-1 and ferritin H chain via a mechanism that involves the transcription-factor nuclear-factor E2-related factor-2 (NRF2).
Journal ArticleDOI
Characterization of plasma labile heme in hemolytic conditions.
Zélia Gouveia,Ana Rita Carlos,Xiaojing Yuan,Frederico Aires-da-Silva,Roland Stocker,Roland Stocker,Ghassan J. Maghzal,Ghassan J. Maghzal,Sónia S. Leal,Cláudio M. Gomes,Smilja Todorovic,Olga Iranzo,Susana Ramos,Ana Catarina Cunha Santos,Iqbal Hamza,João Gonçalves,Miguel P. Soares +16 more
TL;DR: A panel of heme‐specific single domain antibodies (sdAbs) that neutralize the pro‐oxidant activity of soluble heme in vitro are developed and characterized, suggesting that these maybe used to counter the pathologic effects of labile heme during hemolytic conditions.
Journal ArticleDOI
Labile heme impairs hepatic microcirculation and promotes hepatic injury
Franziska A. Englert,Raphael A. Seidel,Kerstin Galler,Zélia Gouveia,Miguel P. Soares,Ute Neugebauer,Mark G. Clemens,Christoph Sponholz,Stefan H. Heinemann,Georg Pohnert,Michael Bauer,Sebastian Weis +11 more
TL;DR: Experimental evidence is provided that heme increases portal pressure via a mechanism that involves hepatic stellate cell-mediated sinusoidal constriction, a hallmark of microcirculatory failure under stress conditions and it is proposed that he me scavenging might be used therapeutically to maintain hepatic microcirculation and organ function in sepsis.
Journal ArticleDOI
Probing the chemotaxis periplasmic sensor domains from Geobacter sulfurreducens by combined resonance Raman and molecular dynamic approaches: NO and CO sensing.
Teresa Catarino,Miguel Pessanha,Ariel G. De Candia,Zélia Gouveia,Ana P. Fernandes,P. Raj Pokkuluri,Daniel H. Murgida,Marcelo A. Marti,Smilja Todorovic,Carlos A. Salgueiro +9 more
TL;DR: Spectroscopic data and MD calculations revealed subtle differences in the binding properties and structural features of formed CO and NO adducts, but also indicated a possibility that a (5c) high-spin/(6c) low-spin redox-linked equilibrium could drive the physiological sensing of Gs cells.