Journal ArticleDOI
Labile heme impairs hepatic microcirculation and promotes hepatic injury
Franziska A. Englert,Raphael A. Seidel,Kerstin Galler,Zélia Gouveia,Miguel P. Soares,Ute Neugebauer,Mark G. Clemens,Christoph Sponholz,Stefan H. Heinemann,Georg Pohnert,Michael Bauer,Sebastian Weis +11 more
TLDR
Experimental evidence is provided that heme increases portal pressure via a mechanism that involves hepatic stellate cell-mediated sinusoidal constriction, a hallmark of microcirculatory failure under stress conditions and it is proposed that he me scavenging might be used therapeutically to maintain hepatic microcirculation and organ function in sepsis.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2019-09-15. It has received 21 citations till now. The article focuses on the topics: Heme binding & Heme.read more
Citations
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Journal ArticleDOI
Haptoglobin Therapeutics and Compartmentalization of Cell-Free Hemoglobin Toxicity
TL;DR: Key concepts of Hb toxicity are discussed and a perspective on the use of haptoglobin as a therapeutic protein is provided, to target 'toxic' cell-free Hb exposures.
Journal ArticleDOI
Hemolysis Derived Products Toxicity and Endothelium: Model of the Second Hit.
TL;DR: The ‘multiple-hit’ theory through the example of intra-vascular hemolysis is illustrated, with a particular focus on cell-free heme, and hypotheses explaining the glomerular susceptibility observed in hemolytic diseases are advanced.
Journal ArticleDOI
The role of immune inflammation in aneurysmal subarachnoid hemorrhage.
TL;DR: The role of immune inflammatory responses in the occurrence and development of aSAh, as well as some inflammatory biomarkers related to CVS, DCI, and aSAH outcomes are discussed.
Journal ArticleDOI
Therapeutic Potential of Heme Oxygenase-1 and Carbon Monoxide in Acute Organ Injury, Critical Illness, and Inflammatory Disorders.
TL;DR: CO, derived from HO activity, has been identified as an endogenous mediator that can influence mitochondrial function and/or cellular signal transduction programs which culminate in the regulation of apoptosis, cellular proliferation, and inflammation.
Journal ArticleDOI
Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme
Elisa Jentho,Elisa Jentho,Cristian Ruiz-Moreno,Boris Novakovic,Boris Novakovic,Ioannis Kourtzelis,Ioannis Kourtzelis,Ioannis Kourtzelis,Wout Megchelenbrink,Rui Martins,Triantafyllos Chavakis,Miguel P. Soares,Lydia Kalafati,Lydia Kalafati,Joel Guerra,Franziska Roestel,Peter Bohm,Maren Godmann,Tatyana Grinenko,Anne Eugster,Martina Beretta,Martina Beretta,Leo A. B. Joosten,Mihai G. Netea,Mihai G. Netea,Michael Bauer,Hendrik G. Stunnenberg,Sebastian Weis +27 more
TL;DR: Soares et al. as mentioned in this paper reported that labile heme is a previously unrecognized inducer of trained immunity that confers long-term regulation of lineage specification of hematopoietic stem cells and progenitor cells.
References
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Journal ArticleDOI
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
Journal ArticleDOI
Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012.
R. P. Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +21 more
TL;DR: An update to the “Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock,” last published in 2008 is provided.
Journal ArticleDOI
Tolerance, danger, and the extended family.
TL;DR: The possibility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues is discussed.
Journal ArticleDOI
Severe sepsis and septic shock
Derek C. Angus,Tom van der Poll +1 more
TL;DR: A review of the basis, diagnosis, and current treatment of Sepsis in patients with this disorder is examined.
Journal ArticleDOI
Mechanisms of Cell Protection by Heme Oxygenase-1
TL;DR: The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death.