Zheng Wei

TL;DR: An important innate immune signalling pathway that functions in intestinal epithelial cells and may present useful targets in the modulation of host defences against viral pathogens is highlighted.

TL;DR: A tumor‐promoting role for Tet2 is revealed, whereby Tet2 functions to sustain an immunosuppressive program in myeloid cells that in turn dampens the anti‐tumor T cell response.

TL;DR: The structure and biosynthesis of autoinducer-3 (AI-3), a metabolite of previously unknown structure involved in the pathogenesis of enterohemorrhagic E. coli (EHEC), are defined and it is shown that the metabolites exert diverse immunological effects on primary human tissues.

TL;DR: Two major fork restart pathways are described, and it is demonstrated that their selection is governed by 53BP1 and BRCA1, which are known to control the pathway choice to repair double-strand DNA breaks (DSBs).

TL;DR: It is shown that the colipterins are antioxidants, harbour diverse immunological activities in primary human tissues, activate anti-inflammatory interleukin-10 and improve colitis symptoms in a colitis mouse model.