H
Hao Xu
Researcher at Yale University
Publications - 36
Citations - 1550
Hao Xu is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & T cell. The author has an hindex of 11, co-authored 31 publications receiving 859 citations. Previous affiliations of Hao Xu include New York University & Peking University.
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Journal ArticleDOI
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
Nicola Gagliani,Maria Carolina Amezcua Vesely,Andrea Iseppon,Leonie Brockmann,Hao Xu,Noah W. Palm,Marcel R. de Zoete,Paula Licona-Limón,Ricardo Paiva,Travers Ching,Casey T. Weaver,Xiaoyuan Zi,Xinghua Pan,Rong Fan,Lana X. Garmire,Matthew J. Cotton,Yotam Drier,Bradley E. Bernstein,Jens Geginat,Brigitta Stockinger,Enric Esplugues,Samuel Huber,Richard A. Flavell +22 more
TL;DR: Two new fate-mapping mouse models are used to show that CD4+ T cells that formerly expressed IL-17A go on to acquire an anti-inflammatory phenotype and suggest that Th17 cell instability and plasticity is a therapeutic opportunity for inflammatory diseases.
Journal ArticleDOI
mRNA destabilization by BTG1 and BTG2 maintains T cell quiescence.
Soo Seok Hwang,Jaechul Lim,Zhibin Yu,Zhibin Yu,Philip Kong,Esen Sefik,Hao Xu,Christian C. D. Harman,Lark Kyun Kim,Gap Ryol Lee,Hua-Bing Li,Hua-Bing Li,Richard A. Flavell,Richard A. Flavell +13 more
TL;DR: This study identifies BTG1 and BTG2 (BTG1/2) as factors responsible for T cell quiescence and suggests that low mRNA abundance is a crucial feature for maintaining quiescent.
Journal ArticleDOI
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
Maria Carolina Amezcua Vesely,Paris Pallis,Piotr Bielecki,Jun Siong Low,Jun Zhao,Christian C. D. Harman,Lina Kroehling,Ruaidhri Jackson,Will Bailis,Paula Licona-Limón,Hao Xu,Norifumi Iijima,Padmini S. Pillai,Daniel H. Kaplan,Casey T. Weaver,Yuval Kluger,Monika S. Kowalczyk,Akiko Iwasaki,João Pereira,Enric Esplugues,Nicola Gagliani,Nicola Gagliani,Nicola Gagliani,Richard A. Flavell +23 more
TL;DR: It is found that a significant fraction of lung CD4 TRM cells derive from IL-17A-producing effector (TH17) cells following immunization with heat-killed Klebsiella pneumonia (Kp).
Journal ArticleDOI
Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution
Bin Li,Wen Zhang,C.B. Guo,Hao Xu,Longfei Li,Minghao Fang,Yinlei Hu,Xinye Zhang,Xinfeng Yao,Meifang Tang,Ke Liu,Xuetong Zhao,Jun Lin,Linzhao Cheng,Falai Chen,Tian Xue,Kun Qu +16 more
TL;DR:
Journal ArticleDOI
Skin-resident innate lymphoid cells converge on a pathogenic effector state.
Piotr Bielecki,Samantha J. Riesenfeld,Samantha J. Riesenfeld,Jan-Christian Hütter,Elena Torlai Triglia,Monika S. Kowalczyk,Roberto R. Ricardo-Gonzalez,Mi Lian,Mi Lian,Maria Carolina Amezcua Vesely,Maria Carolina Amezcua Vesely,Lina Kroehling,Hao Xu,Michal Slyper,Christoph Muus,Christoph Muus,Leif S. Ludwig,Elena Christian,Liming Tao,Amanda J. Kedaigle,Holly R. Steach,Autumn G. York,Mathias H. Skadow,Parastou Yaghoubi,Danielle Dionne,Abigail Jarret,Heather M. McGee,Heather M. McGee,Caroline B. M. Porter,Paula Licona-Limón,Paula Licona-Limón,Will Bailis,Will Bailis,Will Bailis,Ruaidhri Jackson,Nicola Gagliani,Georg Gasteiger,Richard M. Locksley,Richard M. Locksley,Aviv Regev,Richard A. Flavell,Richard A. Flavell +41 more
TL;DR: In this paper, the authors show that the induction of psoriasis in mice by IL-23 or imiquimod reconfigures a spectrum of skin ILCs, which converge on a pathogenic ILC3-like state.