The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression.
Wen Pan,Shu Zhu,Kun Qu,Katrina Meeth,Jijun Cheng,Jijun Cheng,Kaixin He,Hongdi Ma,Yan Liao,Xizhi Wen,Christine Roden,Christine Roden,Zuzana Tobiasova,Zheng Wei,Jun Zhao,Jun Liu,Jun Liu,Ji Zheng,Bo Guo,Sajid A. Khan,Marcus Bosenberg,Richard A. Flavell,Jun Lu,Jun Lu +23 more
TLDR
A tumor‐promoting role for Tet2 is revealed, whereby Tet2 functions to sustain an immunosuppressive program in myeloid cells that in turn dampens the anti‐tumor T cell response.About:
This article is published in Immunity.The article was published on 2017-08-15 and is currently open access. It has received 104 citations till now. The article focuses on the topics: Methylcytosine Dioxygenase TET2 & Haematopoiesis.read more
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Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity.
TL;DR: The varied roles of IL-1 family members in immune homeostasis and their contribution to pathologies, including autoimmunity and auto-inflammation, dysmetabolism, cardiovascular disorders, and cancer are discussed.
Journal ArticleDOI
Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies.
TL;DR: The clinical manifestations of CH, mechanisms contributing to its development, the role of CH in clonal evolution toward leukemia, and the contribution of CH to non-hematological disease states are discussed.
Journal ArticleDOI
IL-1 and IL-1 regulatory pathways in cancer progression and therapy.
TL;DR: The translation potential of IL‐1 targeting deserves extensive analysis, based on initial clinical results, and the role it plays in carcinogenesis and tumor progression.
Journal ArticleDOI
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
Hanghang Zhang,Somnath Pandey,Meghan Travers,Hongxing Sun,George Morton,Jozef Madzo,Woonbok Chung,Jittasak Khowsathit,Oscar Perez-Leal,Carlos A. Barrero,Carmen Merali,Yasuyuki Okamoto,Takahiro Sato,Joshua Pan,Judit Garriga,Natarajan V. Bhanu,Johayra Simithy,Bela Patel,Jian Huang,Noël J.-M. Raynal,Benjamin A. Garcia,Marlene A. Jacobson,Cigall Kadoch,Salim Merali,Yi Zhang,Wayne E. Childers,Magid Abou-Gharbia,John Karanicolas,Stephen B. Baylin,Cynthia A. Zahnow,Jaroslav Jelinek,Xavier Graña,Jean Pierre J. Issa +32 more
TL;DR: It is discovered that CDK9 inhibition reactivates epigenetically silenced genes in cancer, leading to restored tumor suppressor gene expression, cell differentiation, and activation of endogenous retrovirus genes.
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MDSC: Markers, development, states, and unaddressed complexity.
TL;DR: In this paper, the authors proposed a framework to classify myeloid-derived suppressor cells (MDSCs) as discrete cell states based on activation signals in myeloids.
References
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Mutations of the BRAF gene in human cancer
Helen Davies,Graham R. Bignell,Charles Cox,Philip J. Stephens,Sarah Edkins,S. M. Clegg,Jon W. Teague,Hayley Woffendin,Mathew J. Garnett,William Bottomley,Neil Davis,Ed Dicks,Rebecca Ewing,Yvonne Floyd,Kristian Gray,S. Hall,Rachel Hawes,Jaime Hughes,Vivian Kosmidou,Andrew Menzies,Catherine Mould,Adrian Parker,Claire Stevens,Stephen Watt,Steven Hooper,Rebecca Wilson,Hiran Jayatilake,Barry A. Gusterson,Colin Cooper,Janet Shipley,Darren Hargrave,Kathy Pritchard-Jones,Norman J. Maitland,Georgia Chenevix-Trench,Gregory J. Riggins,Darell D. Bigner,Giuseppe Palmieri,Antonio Cossu,Adrienne M. Flanagan,Andrew G. Nicholson,Judy W. C. Ho,Suet Yi Leung,Siu Tsan Yuen,Barbara L. Weber,Hilliard F. Seigler,Timothy L. Darrow,Hugh Paterson,Richard Marais,Christopher J. Marshall,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +51 more
TL;DR: BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.
Journal ArticleDOI
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
Mamta Tahiliani,Kian Peng Koh,Yinghua Shen,William A. Pastor,Hozefa S. Bandukwala,Yevgeny Brudno,Suneet Agarwal,Lakshminarayan M. Iyer,David R. Liu,L. Aravind,Anjana Rao +10 more
TL;DR: It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro.
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Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.
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Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
Siddhartha Jaiswal,Pierre Fontanillas,Jason Flannick,Jason Flannick,Alisa K. Manning,Peter V. Grauman,Brenton G. Mar,Brenton G. Mar,R. Coleman Lindsley,Craig H. Mermel,Noël P. Burtt,Alejandro Chavez,John M. Higgins,Vladislav Moltchanov,Vladislav Moltchanov,Frank C. Kuo,Michael J. Kluk,Brian E. Henderson,Leena Kinnunen,Heikki A. Koistinen,Heikki A. Koistinen,Claes Ladenvall,Gad Getz,Adolfo Correa,Benjamin F. Banahan,Stacey Gabriel,Stacey Gabriel,Sekar Kathiresan,Heather M. Stringham,Mark I. McCarthy,Michael Boehnke,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Christopher A. Haiman,Leif Groop,Gil Atzmon,James G. Wilson,Donna Neuberg,David Altshuler,Benjamin L. Ebert +40 more
TL;DR: Age-related clonal hematopoiesis is a common condition that is associated with increases in the risk of hematologic cancer and in all-cause mortality, with the latter possibly due to an increased risk of cardiovascular disease.
Journal ArticleDOI
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Shinsuke Ito,Li Shen,Qing Dai,Susan C. Wu,Leonard B. Collins,James A. Swenberg,Chuan He,Yi Zhang +7 more
TL;DR: This study raises the possibility that DNA demethylation may occur through Tet-catalyzed oxidation followed by decarboxylation, and identifies two previously unknown cytosine derivatives in genomic DNA as the products of Tet proteins.
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