Z
Zhiqi Hao
Researcher at Thermo Fisher Scientific
Publications - 7
Citations - 638
Zhiqi Hao is an academic researcher from Thermo Fisher Scientific. The author has contributed to research in topics: Mass spectrometry & Chemistry. The author has an hindex of 4, co-authored 5 publications receiving 575 citations.
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Journal ArticleDOI
Identification of cross-linked peptides from complex samples
Bing Yang,Yan-Jie Wu,Ming Zhu,Sheng-Bo Fan,Jinzhong Lin,Kun Zhang,Shuang Li,Hao Chi,Yu-Xin Li,Hai-Feng Chen,Shukun Luo,Yue-He Ding,Le-Heng Wang,Zhiqi Hao,Li-Yun Xiu,She Chen,Keqiong Ye,Si-Min He,Meng-Qiu Dong +18 more
TL;DR: pLink as mentioned in this paper is a software for data analysis of cross-linked proteins coupled with mass-spectrometry analysis, which is compatible with multiple homo- or hetero-bifunctional cross-linkers.
Journal ArticleDOI
Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin)
Yanmei Zhao,Wei Sun,Pan Zhang,Hao Chi,Mei-Jun Zhang,Chun-Qing Song,Xuan Ma,Yunlong Shang,Bin Wang,Youqiao Hu,Zhiqi Hao,Andreas Huhmer,Fanxia Meng,Steven W. L'Hernault,Si-Min He,Meng-Qiu Dong,Long Miao +16 more
TL;DR: It is shown that As_SRP-1 has two major functions, one of which functions in cis to support major sperm protein (MSP)-based cytoskeletal assembly in the spermatid that releases it, thereby facilitating sperm motility acquisition and the other released from an activated sperm inhibits the activation of surrounding sperMatids.
Journal ArticleDOI
Analysis of the trypanosome flagellar proteome using a combined electron transfer collisionally activated dissociation strategy.
Sarah R. Hart,King Wai Lau,Zhiqi Hao,Richard Broadhead,Neil Portman,Andreas Huhmer,Keith Gull,Paul G. McKean,Simon J. Hubbard,Simon J. Gaskell +9 more
TL;DR: A combined ETD/CAD approach leads to the recognition of more peptides and proteins than are achieved using peptide analysis by CAD- or ETD-based tandem mass spectrometry alone.
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Charger: combination of signal processing and statistical learning algorithms for precursor charge-state determination from electron-transfer dissociation spectra.
TL;DR: This work has developed an approach for charge-state determination of peptides from their tandem mass spectra obtained in fragmentations via electron-transfer dissociation (ETD) reactions, and discusses the cost associated with the possible misclassification of charge states.
Journal ArticleDOI
A Robust Purity Method for Biotherapeutics Using New Peak Detection in an LC-MS-Based Multi-Attribute Method.
Monica Sadek,Benjamin Nathan Moore,Christopher Yu,Nicholas Ruppe,Austin Abdun-Nabi,Zhiqi Hao,Melissa Alvarez,Sanket N. Dahotre,Galahad Deperalta +8 more
TL;DR: In this paper , a new peak detection (NPD) method is proposed for sensitive and unbiased detection of new or changing site-specific attributes between a sample and reference that is not possible with conventional UV or fluorescence detection-based methods.