Institution
Children's Memorial Hospital
Healthcare•
About: Children's Memorial Hospital is a based out in . It is known for research contribution in the topics: Population & Transplantation. The organization has 5652 authors who have published 8967 publications receiving 283837 citations.
Topics: Population, Transplantation, Medicine, Poison control, Health care
Papers published on a yearly basis
Papers
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Anschutz Medical Campus1, National Institute for Health Research2, University of Washington3, Charité4, University College Dublin5, University of Medicine and Health Sciences6, University of British Columbia7, University of Alabama at Birmingham8, St. Michael's Hospital9, Vertex Pharmaceuticals10, University of Queensland11, Children's Memorial Hospital12, Northwestern University13
TL;DR: In this article, Elexacaftor/tezacaftors/ivacaftors (ELX/TEZ/IVA) was shown to be efficacious and safe in patients ≥ 12 years of age with CF and at least one F508del-CFTR (cystic fibrosis trans...
Abstract: Rationale: Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) was shown to be efficacious and safe in patients ≥12 years of age with cystic fibrosis and at least one F508del-CFTR (cystic fibrosis trans...
104 citations
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TL;DR: The early identification and treatment of childhood-onset depression is an important clinical task for all pediatric specialists and safe and effective multimodal treatment approaches are available.
104 citations
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Washington University in St. Louis1, Children's National Medical Center2, Children's Hospital of Philadelphia3, Cincinnati Children's Hospital Medical Center4, Boston Children's Hospital5, University of Miami6, Children's Memorial Hospital7, University Medical Center New Orleans8, Children's Mercy Hospital9, All Children's Hospital10, University of North Carolina at Chapel Hill11, Riley Hospital for Children12
TL;DR: Findings support using RIC for patients with hemoglobinopathy undergoing matched sibling marrow transplantation with matched sibling donor marrow following reduced intensity conditioning with alemtuzumab, fludarabine, and melphalan.
Abstract: Fifty-two children with symptomatic sickle cell disease sickle cell disease (SCD) (N = 43) or transfusion-dependent thalassemia (N = 9) received matched sibling donor marrow (46), marrow and cord product (5), or cord blood (1) allografts following reduced intensity conditioning (RIC) with alemtuzumab, fludarabine, and melphalan between March 2003 and May 2014*. The Kaplan-Meier probabilities of overall and event-free survival at a median of 3.42 (range, 0.75-11.83) years were 94.2% and 92.3% for the group, 93% and 90.7% for SCD, and 100% and 100% for thalassemia, respectively. Treatment-related mortality (all related to graft versus host disease, GVHD) was noted in three (5.7%) recipients, all 17-18 years of age. Acute and chronic GVHD was noted in 23% and 13%, respectively, with 81% of recipients off immunosuppression by 1 year. Graft rejection was limited to the single umbilical cord blood recipient who had prompt autologous hematopoietic recovery. Fourteen (27%) had mixed chimerism at 1 year and beyond; all had discontinued immunosuppression between 4 and 12 months from transplant with no subsequent consequence on GVHD or rejection. Infectious complications included predominantly bacteremia (48% were staphylococcus) and CMV reactivation (43%) necessitating preemptive therapy. Lymphocyte recovery beyond 6 months was associated with subsidence of infectious complications. All patients who engrafted were transfusion independent; no strokes or pulmonary complications of SCD were noted, and pain symptoms subsided within 6 months posttransplant. These findings support using RIC for patients with hemoglobinopathy undergoing matched sibling marrow transplantation (*www.Clinical Trials.gov: NCT00920972, NCT01050855, NCT02435901).
103 citations
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TL;DR: A modified glanuloplasty is described for the selective repair of glanular and coronal hypospadias with a wide, deepglanular groove and noncompliant urethral meatus with excellent cosmetic and functional results.
103 citations
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103 citations
Authors
Showing all 5672 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jorge E. Cortes | 163 | 2784 | 124154 |
Marc C. Hochberg | 127 | 691 | 87268 |
Michael Andreeff | 117 | 959 | 54734 |
Bharat Bhushan | 116 | 1276 | 62506 |
Donald M. Lloyd-Jones | 115 | 706 | 112655 |
David N. Herndon | 108 | 1227 | 54888 |
Frederick J. Schoen | 102 | 434 | 42611 |
Kathryn M. Edwards | 102 | 628 | 39467 |
Alan R. Dyer | 95 | 283 | 44252 |
Mark C. Willingham | 94 | 394 | 36167 |
Nicholas Katsanis | 93 | 348 | 34133 |
Peter D. Gluckman | 92 | 525 | 33375 |
Helga Refsum | 90 | 316 | 37463 |
Dale A. Schoeller | 90 | 391 | 30776 |
Shlomo Shinnar | 90 | 288 | 25621 |