Institution
Children's Memorial Hospital
Healthcare•
About: Children's Memorial Hospital is a based out in . It is known for research contribution in the topics: Population & Transplantation. The organization has 5652 authors who have published 8967 publications receiving 283837 citations.
Topics: Population, Transplantation, Medicine, Poison control, Health care
Papers published on a yearly basis
Papers
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TL;DR: Results suggest a higher prevalence of cognitive and academic delays and learning problems in pediatric LT recipients compared to the normal population.
101 citations
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TL;DR: Molecular analysis revealed that foci of malignancy and adjacent areas of hyperplasia and some areas of normal thyroid harbored activating mutations of Arg 201 in the GNAS1 gene, suggesting that the infrequent development of thyroid carcinoma in MAS patients involves additional mutational or epigenetic events.
Abstract: McCune-Albright syndrome (MAS) is defined by the triad of cafe ´ -au-lait skin pigmentation, polyostotic fibrous dysplasia, and hyperfunctioning endocrinopathies, such as precocious puberty, hyperthyroidism, GH excess, and Cushing’s syndrome. This disorder is caused by sporadic, postzygotic activating mutations in the GNAS1 gene, which codes for the Gs protein in the cAMP signaling cascade. Nodular and diffuse goiters (with and without hyperthyroidism), as well as benign thyroid nodules, have been reported in association with MAS. Herein we report two cases of thyroid carcinoma in patients with MAS. The first is a case of papillary thyroid cancer detected incidentally during a hemithyroidectomy for hyperthyroidism in a 14-yr-old girl. The second is one of a 41-yr-old woman with long-standing MAS and an enlarging thyroid nodule, which was diagnosed as a clear cell thyroid carcinoma, a rare variant of thyroid cancer. Molecular analysis revealed that foci of malignancy and adjacent areas of hyperplasia and some areas of normal thyroid harbored activating mutations of Arg 201 in the GNAS1 gene. These findings suggest that the infrequent development of thyroid carcinoma in MAS patients involves additional mutational or epigenetic events. (J Clin Endocrinol Metab 88: 4413– 4417, 2003)
101 citations
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TL;DR: Cough‐variant asthma was the most common cause of cough, followed by sinusitis, gastroesophageal reflux, aberrant innominate artery, psychogenic cough, and sub‐glottic stenosis.
Abstract: Cough is a symptom frequently encountered by the otolaryngologist--head and neck surgeon. Although most coughs are self limited, chronic cough often proves to be a frustrating problem. Seventy-two infants and children under age 16 with a normal chest radiogram have now been evaluated for chronic cough persisting for longer than 4 weeks. Cough-variant asthma was the most common cause of cough, followed by sinusitis, gastroesophageal reflux, aberrant innominate artery, psychogenic cough, and subglottic stenosis. Chronic cough is best managed by first following an individualized diagnostic protocol designed to determine the etiology of the cough. This is followed by specific therapy to treat the underlying disorder. Children with persistent cough and normal chest radiograph are best served when referred promptly for evaluation by an otolaryngologist when the primary physician's initial efforts at diagnosis and treatment are not effective. Endoscopy is underutilized in practice and its importance understated in the literature. It is particularly helpful in establishing a precise diagnosis in infants under 18 months of age.
101 citations
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University of Texas Southwestern Medical Center1, Seattle Children's Research Institute2, University of Lübeck3, Royal Victoria Infirmary4, Tehran University of Medical Sciences5, Cincinnati Children's Hospital Medical Center6, Boston Children's Hospital7, University of South Florida8, University of California, Los Angeles9, University of California, San Francisco10, Katholieke Universiteit Leuven11, University of Utah12, Emory University13, Children's Hospital Los Angeles14, University of Oxford15, University Medical Center Freiburg16, Masaryk University17, Children's Hospital of Wisconsin18, Children's Hospital at Westmead19, Children's Memorial Hospital20, Royal Free Hospital21, Memorial Sloan Kettering Cancer Center22, Children's Hospital of Philadelphia23, Ege University24, Mount Sinai Hospital25, Saint Louis University26, Duke University27, Federal University of São Paulo28, University of São Paulo29, National Institutes of Health30
TL;DR: No difference in survival was observed between patients treated with or without HCT across all diagnosis years (1964‐2013), however, survivors treated with HCT experienced somewhat greater well‐being, and hazards associated with H CT decreased, reaching levels of significantly less risk in the late 1990s.
Abstract: Background X-linked hyper-IgM syndrome (XHIGM) is a primary immunodeficiency with high morbidity and mortality compared with those seen in healthy subjects. Hematopoietic cell transplantation (HCT) has been considered a curative therapy, but the procedure has inherent complications and might not be available for all patients. Objectives We sought to collect data on the clinical presentation, treatment, and follow-up of a large sample of patients with XHIGM to (1) compare long-term overall survival and general well-being of patients treated with or without HCT along with clinical factors associated with mortality and (2) summarize clinical practice and risk factors in the subgroup of patients treated with HCT. Methods Physicians caring for patients with primary immunodeficiency diseases were identified through the Jeffrey Modell Foundation, United States Immunodeficiency Network, Latin American Society for Immunodeficiency, and Primary Immune Deficiency Treatment Consortium. Data were collected with a Research Electronic Data Capture Web application. Survival from time of diagnosis or transplantation was estimated by using the Kaplan-Meier method compared with log-rank tests and modeled by using proportional hazards regression. Results Twenty-eight clinical sites provided data on 189 patients given a diagnosis of XHIGM between 1964 and 2013; 176 had valid follow-up and vital status information. Sixty-seven (38%) patients received HCT. The average follow-up time was 8.5 ± 7.2 years (range, 0.1-36.2 years). No difference in overall survival was observed between patients treated with or without HCT ( P = .671). However, risk associated with HCT decreased for diagnosis years 1987-1995; the hazard ratio was significantly less than 1 for diagnosis years 1995-1999. Liver disease was a significant predictor of overall survival (hazard ratio, 4.9; 95% confidence limits, 2.2-10.8; P P Conclusion No difference in survival was observed between patients treated with or without HCT across all diagnosis years (1964-2013). However, survivors treated with HCT experienced somewhat greater well-being, and hazards associated with HCT decreased, reaching levels of significantly less risk in the late 1990s. Among patients treated with HCT, treatment at an early age is associated with improved survival. Optimism remains guarded as additional evidence accumulates.
101 citations
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TL;DR: MLVI, a marker of medication adherence that uses clinically derived information, predicts LAR in pediatric liver transplant recipients, and was significantly associated with all secondary outcomes.
101 citations
Authors
Showing all 5672 results
Name | H-index | Papers | Citations |
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Jorge E. Cortes | 163 | 2784 | 124154 |
Marc C. Hochberg | 127 | 691 | 87268 |
Michael Andreeff | 117 | 959 | 54734 |
Bharat Bhushan | 116 | 1276 | 62506 |
Donald M. Lloyd-Jones | 115 | 706 | 112655 |
David N. Herndon | 108 | 1227 | 54888 |
Frederick J. Schoen | 102 | 434 | 42611 |
Kathryn M. Edwards | 102 | 628 | 39467 |
Alan R. Dyer | 95 | 283 | 44252 |
Mark C. Willingham | 94 | 394 | 36167 |
Nicholas Katsanis | 93 | 348 | 34133 |
Peter D. Gluckman | 92 | 525 | 33375 |
Helga Refsum | 90 | 316 | 37463 |
Dale A. Schoeller | 90 | 391 | 30776 |
Shlomo Shinnar | 90 | 288 | 25621 |