Institution
Children's Memorial Hospital
Healthcare•
About: Children's Memorial Hospital is a based out in . It is known for research contribution in the topics: Population & Transplantation. The organization has 5652 authors who have published 8967 publications receiving 283837 citations.
Topics: Population, Transplantation, Medicine, Poison control, Health care
Papers published on a yearly basis
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University of California, San Francisco1, Children's Hospital Oakland Research Institute2, Northwestern University3, Baylor College of Medicine4, Jacobi Medical Center5, Kaiser Permanente6, United States Department of Veterans Affairs7, Children's Memorial Hospital8, Henry Ford Health System9, Lehman College10
TL;DR: Socioeconomic status plays an important role in predicting asthma, but has different effects depending on race and ethnicity, and further steps are necessary to better understand the risk factors through which socioeconomic status could operate in these populations to prevent asthma.
Abstract: Rationale: The burden of asthma is highest among socioeconomically disadvantaged populations; however, its impact is differentially distributed among racial and ethnic groups.Objectives: To assess the collective effect of maternal educational attainment, annual household income, and insurance type on childhood asthma among minority, urban youth.Methods: We included Mexican American (n = 485), other Latino (n = 217), and African American (n = 1,141) children (aged 8–21 yr) with and without asthma from the San Francisco Bay Area. An index was derived from maternal educational attainment, annual household income, and insurance type to assess the collective effect of socioeconomic status on predicting asthma. Logistic regression stratified by racial and ethnic group was used to estimate adjusted odds ratios (aOR) and their 95% confidence intervals (CI). We further examined whether acculturation explained the socioeconomic-asthma association in our Latino population.Measurements and Main Results: In the adjust...
114 citations
Baylor College of Medicine1, National Institutes of Health2, Duke University3, University of Iowa4, University at Buffalo5, Harvard University6, University of Tennessee Health Science Center7, Icahn School of Medicine at Mount Sinai8, Cincinnati Children's Hospital Medical Center9, Children's Memorial Hospital10, University of Colorado Denver11, Boston Children's Hospital12, Johns Hopkins University13, Seattle Children's14, University of California, San Francisco15, Children's Hospital of Wisconsin16, University of California, Los Angeles17, University of Pennsylvania18
TL;DR: In this paper, the authors defined close-contact spread of infectious disease as a type of transmission that is particularly relevant in patients with impaired immunity who might have an infection when exposed to subjects carrying vaccine-preventable infectious diseases or who have recently received a live vaccine.
Abstract: The present uncertainty of which live viral or bacterial vaccines can be given to immunodeficient patients and the growing neglect of societal adherence to routine immunizations has prompted the Medical Advisory Committee of the Immune Deficiency Foundation to issue recommendations based on published literature and the collective experience of the committee members. These recommendations address the concern for immunodeficient patients acquiring infections from healthy subjects who have not been immunized or who are shedding live vaccine–derived viral or bacterial organisms. Such transmission of infectious agents can occur within the hospital, clinic, or home or at any public gathering. Collectively, we define this type of transmission as close-contact spread of infectious disease that is particularly relevant in patients with impaired immunity who might have an infection when exposed to subjects carrying vaccine-preventable infectious diseases or who have recently received a live vaccine. Immunodeficient patients who have received therapeutic hematopoietic stem transplantation are also at risk during the time when immune reconstitution is incomplete or while they are receiving immunosuppressive agents to prevent or treat graft-versus-host disease. This review recommends the general education of what is known about vaccine-preventable or vaccine-derived diseases being spread to immunodeficient patients at risk for close-contact spread of infection and describes the relative risks for a child with severe immunodeficiency. The review also recommends a balance between the need to protect vulnerable subjects and their social needs to integrate into society, attend school, and benefit from peer education.
113 citations
Journal Article•
Indiana University – Purdue University Indianapolis1, University of Tennessee Health Science Center2, University of Washington3, Ohio State University4, Saint Louis University5, Children's Memorial Hospital6, University of Cincinnati7, Children's Hospital of Orange County8, University of Louisville9, Boston Children's Hospital10, University of Kansas11
TL;DR: In these children treated prior to the era of biologic therapy, at 5 years after onset, > 25% of poly and nearly half of systemic patients had functional limitations that required modifications in their school schedule.
Abstract: OBJECTIVE: To describe the health and functional status of children with juvenile rheumatoid arthritis (JRA) diagnosed in the early 1990s. METHODS: Patients were obtained from the Pediatric Rheumatology Disease Registry, a database of patients seen in pediatric rheumatology centers across the United States. Questionnaires designed to be filled out after retrospective chart review were sent to pediatric rheumatologists caring for children diagnosed with JRA between 1992 and 1997. RESULTS: We studied 703 patients -- 376 with pauciarticular onset (pauci), 232 with polyarticular onset (poly), and 95 with systemic onset JRA (systemic). At 1 year after diagnosis, half of the pauci and systemic patients no longer required medication, compared to 78% of the poly patients; 98% of the patients functioned in Steinbrocker classes I and II. Six percent of pauci, 27% of poly, and 11% of systemic patients had limitations in school function. Nearly 1/3 of poly patients already had joint space narrowing on radiograph. By 5 years after diagnosis, all pauci, 88% of poly, and 70% of systemic patients were in Steinbrocker classes I and II; but 6% of pauci, 28% of poly, and 44% of systemic patients had limitations in school function. Nearly 2/3 of poly and systemic patients had joint space narrowing. CONCLUSION: In these children treated prior to the era of biologic therapy, at 5 years after onset, > 25% of poly and nearly half of systemic patients had functional limitations that required modifications in their school schedule. Radiographically evident joint space damage was seen within a year of onset in poly patients, and by 5 years 2/3 of poly and systemic patients had damage.
113 citations
Children's National Medical Center1, University of California, San Francisco2, University of Amsterdam3, National Institutes of Health4, German Cancer Research Center5, Heidelberg University6, University of Toronto7, University of Colorado Denver8, University of Padua9, Harvard University10, University of Texas Southwestern Medical Center11, Children's Memorial Hospital12, Northwestern University13, McGill University14
TL;DR: The conclusions and recommendations of a consensus conference of how best to integrate the growing body of molecular genetic information into tumor classifications and, more importantly, for future treatment of pediatric LGGs are summarized here.
Abstract: For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular signaling in the Ras-mitogen-activated protein kinase pathway. The conclusions and recommendations of a consensus conference of how best to integrate the growing body of molecular genetic information into tumor classifications and, more importantly, for future treatment of pediatric LGGs are summarized here. There is uniform agreement that molecular characterization must be incorporated into classification and is increasingly critical for appropriate management. Molecular-targeted therapies should be integrated expeditiously, but also carefully into the management of these tumors and success measured not only by radiographic responses or stability, but also by functional outcomes. These trials need to be carried out with the caveat that the long-term impact of molecularly targeted therapy on the developing nervous system, especially with long duration treatment, is essentially unknown.
113 citations
TL;DR: PTNFL is defined as a biologically and clinically distinct indolent lymphoma of children and adults characterized by a high prevalence of MAPK pathway mutations and a near absence of mutations in epigenetic modifiers.
113 citations
Authors
Showing all 5672 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jorge E. Cortes | 163 | 2784 | 124154 |
| Marc C. Hochberg | 127 | 691 | 87268 |
| Michael Andreeff | 117 | 959 | 54734 |
| Bharat Bhushan | 116 | 1276 | 62506 |
| Donald M. Lloyd-Jones | 115 | 706 | 112655 |
| David N. Herndon | 108 | 1227 | 54888 |
| Frederick J. Schoen | 102 | 434 | 42611 |
| Kathryn M. Edwards | 102 | 628 | 39467 |
| Alan R. Dyer | 95 | 283 | 44252 |
| Mark C. Willingham | 94 | 394 | 36167 |
| Nicholas Katsanis | 93 | 348 | 34133 |
| Peter D. Gluckman | 92 | 525 | 33375 |
| Helga Refsum | 90 | 316 | 37463 |
| Dale A. Schoeller | 90 | 391 | 30776 |
| Shlomo Shinnar | 90 | 288 | 25621 |