King Saud University

About: King Saud University is a education organization based out in Riyadh, Saudi Arabia. It is known for research contribution in the topics: Population & Adsorption. The organization has 22106 authors who have published 57908 publications receiving 1042234 citations. The organization is also known as: Riyadh University.

b-SPECS+: Batch Verification for Secure Pseudonymous Authentication in VANET

Abstract: The security and privacy preservation issues are prerequisites for vehicular ad hoc networks. Recently, secure and privacy enhancing communication schemes (SPECS) was proposed and focused on intervehicle communications. SPECS provided a software-based solution to satisfy the privacy requirement and gave lower message overhead and higher successful rate than previous solutions in the message verification phase. SPECS also presented the first group communication protocol to allow vehicles to authenticate and securely communicate with others in a group of known vehicles. Unfortunately, we find out that SPECS is vulnerable to impersonation attack. SPECS has a flow such that a malicious vehicle can force arbitrary vehicles to broadcast fake messages to other vehicles or even a malicious vehicle in the group can counterfeit another group member to send fake messages securely among themselves. In this paper, we provide a secure scheme that can achieve the security and privacy requirements, and overcome the weaknesses of SPECS. Moreover, we show the efficiency merits of our scheme through performance evaluations in terms of verification delay and transmission overhead.

Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity.

Abstract: The effects of thymoquinone (TQ) on cisplatin-induced nephrotoxicity in mice and rats were studied. Oral administration of TQ (50 mg/L in drinking water) for 5 days before and 5 days after single injections of cisplatin (5 mg/kg, i.v., in rats and 7 or 14 mg/kg, i.p., in mice) greatly ameliorated cisplatin-induced nephrotoxicity in both species. In rats, i.v. cisplatin caused 4- and 5-fold elevations in serum urea and creatinine, a 235% increase in urine volume, a 41% increase in kidney weight, 8.5-fold decrease in creatinine clearance, and extensive histological damage 5 days after treatment. In mice, similar alterations in kidney function were observed. TQ-induced amelioration of cisplatin nephrotoxicity was evident by significant reductions in serum urea and creatinine and significant improvement in polyuria, kidney weight, and creatinine clearance. The protective effects of TQ against cisplatin-induced nephrotoxicity in the rat were further confirmed by histopathological examination. To evaluate the possible modification of the antitumor activity of cisplatin by TQ, we studied their interaction in Ehrlich ascites carcinoma (EAC) bearing mice. The results revealed that TQ potentiated the antitumor activity of cisplatin. The current study suggests that TQ may improve the therapeutic index of cisplatin.