Institution
King Saud University
Education•Riyadh, Saudi Arabia•
About: King Saud University is a education organization based out in Riyadh, Saudi Arabia. It is known for research contribution in the topics: Population & Adsorption. The organization has 22106 authors who have published 57908 publications receiving 1042234 citations. The organization is also known as: Riyadh University.
Topics: Population, Adsorption, Medicine, Catalysis, Oxidative stress
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The COVID Human Genetic Effort established to test the general hypothesis that life-threatening COVID-19 in some or most patients may be caused by monogenic inborn errors of immunity to SARS-CoV-2 with incomplete or complete penetrance finds an enrichment in variants predicted to be loss-of-function (pLOF), with a minor allele frequency <0.001.
Abstract: Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.
1,659 citations
••
Nicholas J Kassebaum1, Megha Arora1, Ryan M Barber1, Zulfiqar A Bhutta2 +679 more•Institutions (268)
TL;DR: In this paper, the authors used the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015.
1,533 citations
••
James Bentham1, Mariachiara Di Cesare2, Mariachiara Di Cesare1, Gretchen A Stevens3 +787 more•Institutions (246)
TL;DR: The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3–19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8–144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
1,348 citations
••
Population Health Research Institute1, National University of Ireland, Galway2, St. John's Medical College3, Eduardo Mondlane University4, Glasgow Royal Infirmary5, Sahlgrenska University Hospital6, University of Western Australia7, University of the Philippines8, Mulago Hospital9, University Hospital Bonn10, Aga Khan University11, Universiti Teknologi MARA12, UCSI University13, Dubai Health Authority14, Istanbul Medeniyet University15, University of La Frontera16, University College Hospital, Ibadan17, University of Copenhagen18, Cayetano Heredia University19, University of Split20, Rush University Medical Center21, King Saud University22, University of Limpopo23, Mahidol University24
TL;DR: The importance of potentially modifiable risk factors for stroke in different regions of the world, and in key populations and primary pathological subtypes of stroke, was quantified.
1,313 citations
••
01 Jan 2018
TL;DR: In this paper, a general approach to a series of monodispersed atomic transition metals (for example, Fe, Co, Ni) embedded in nitrogen-doped graphene with a common MN4C4 moiety, identified by systematic X-ray absorption fine structure analyses and direct transmission electron microscopy imaging, was reported.
Abstract: Single-atom catalysts (SACs) have recently attracted broad research interest as they combine the merits of both homogeneous and heterogeneous catalysts. Rational design and synthesis of SACs are of immense significance but have so far been plagued by the lack of a definitive correlation between structure and catalytic properties. Here, we report a general approach to a series of monodispersed atomic transition metals (for example, Fe, Co, Ni) embedded in nitrogen-doped graphene with a common MN4C4 moiety, identified by systematic X-ray absorption fine structure analyses and direct transmission electron microscopy imaging. The unambiguous structure determination allows density functional theoretical prediction of MN4C4 moieties as efficient oxygen evolution catalysts with activities following the trend Ni > Co > Fe, which is confirmed by electrochemical measurements. Determination of atomistic structure and its correlation with catalytic properties represents a critical step towards the rational design and synthesis of precious or nonprecious SACs with exceptional atom utilization efficiency and catalytic activities.
1,305 citations
Authors
Showing all 22392 results
Name | H-index | Papers | Citations |
---|---|---|---|
George P. Chrousos | 169 | 1612 | 120752 |
David W. Bates | 159 | 1239 | 116698 |
Herbert W. Marsh | 152 | 646 | 89512 |
David J.P. Barker | 148 | 446 | 99373 |
Seeram Ramakrishna | 147 | 1552 | 99284 |
Peter J. Schwartz | 147 | 647 | 107695 |
Yu Huang | 136 | 1492 | 89209 |
Damià Barceló | 135 | 1379 | 83714 |
Claudiu T. Supuran | 134 | 1973 | 86850 |
Avelino Corma | 134 | 1049 | 89095 |
Helmut Sies | 133 | 670 | 78319 |
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Meinrat O. Andreae | 131 | 700 | 72714 |
Wajid Ali Khan | 128 | 1272 | 79308 |
Paul M. Vanhoutte | 127 | 868 | 62177 |