Lancaster University

About: Lancaster University is a education organization based out in Lancaster, Lancashire, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 13080 authors who have published 44563 publications receiving 1692277 citations. The organization is also known as: The University of Lancaster & Lancaster University.

Interference in immediate spatial memory

Abstract: It has been suggested that maintenance in visuospatial immediate memory involves implicit motor processes that are analogous to the articulatory loop in verbal memory. An alternative account, which is explored here, is that maintenance is based on shifts of spatial attention. In four experiments, subjects recalled spatial memory span items after an interval, and in a fifth experiment, digit span was recalled after an interval. The tasks carried out during the interval included touching visual targets, repeating heard words, listening to tones from spatially separated locations, pointing to these tones, pointing to visual targets, and categorizing spatial targets as being from the left or right. Spatial span recall was impaired if subjects saw visual targets or heard tones, and this impairment was increased if either a motor response or a categorical response was made. Repeating words heard in different spatial locations did not impair recall, but reading visually presented words did interfere. For digit span only, the tasks involving a verbal response impaired recall. The results are interpreted within a framework in which active spatial attention is involved in maintaining spatial items in order in memory, and is interfered with by any task (visual, auditory, perceptual, motor) that also makes demands on spatial attention.

Combined corticosteroid and long-acting beta-agonist in one inhaler versus inhaled steroids for chronic obstructive pulmonary disease

Abstract: Background Both inhaled steroids (ICS) and long-acting beta2-agonists (LABA) are used in the management of chronic obstructive pulmonary disease (COPD). This updated review compared compound LABA plus ICS therapy (LABA/ICS) with the LABA component drug given alone. Objectives To assess the efficacy of ICS and LABA in a single inhaler with mono-component LABA alone in adults with COPD. Search methods We searched the Cochrane Airways Group Specialised Register of trials. The date of the most recent search was November 2011. Selection criteria We included randomised, double-blind controlled trials. We included trials comparing compound ICS and LABA preparations with their component LABA preparations in people with COPD. Data collection and analysis Two authors independently assessed study risk of bias and extracted data. The primary outcomes were exacerbations, mortality and pneumonia, while secondary outcomes were health-related quality of life (measured by validated scales), lung function, withdrawals due to lack of efficacy, withdrawals due to adverse events and side-effects. Dichotomous data were analysed as random-effects model odds ratios or rate ratios with 95% confidence intervals (CIs), and continuous data as mean differences and 95% CIs. We rated the quality of evidence for exacerbations, mortality and pneumonia according to recommendations made by the GRADE working group. Main results Fourteen studies met the inclusion criteria, randomising 11,794 people with severe COPD. We looked at any LABA plus ICS inhaler (LABA/ICS) versus the same LABA component alone, and then we looked at the 10 studies which assessed fluticasone plus salmeterol (FPS) and the four studies assessing budesonide plus formoterol (BDF) separately. The studies were well-designed with low risk of bias for randomisation and blinding but they had high rates of attrition, which reduced our confidence in the results for outcomes other than mortality. Primary outcomes There was low quality evidence that exacerbation rates in people using LABA/ICS inhalers were lower in comparison to those with LABA alone, from nine studies which randomised 9921 participants (rate ratio 0.76; 95% CI 0.68 to 0.84). This corresponds to one exacerbation per person per year on LABA and 0.76 exacerbations per person per year on ICS/LABA. Our confidence in this effect was limited by statistical heterogeneity between the results of the studies (I2 = 68%) and a risk of bias from the high withdrawal rates across the studies. When analysed as the number of people experiencing one or more exacerbations over the course of the study, FPS lowered the odds of an exacerbation with an odds ratio (OR) of 0.83 (95% CI 0.70 to 0.98, 6 studies, 3357 participants). With a risk of an exacerbation of 47% in the LABA group over one year, 42% of people treated with LABA/ICS would be expected to experience an exacerbation. Concerns over the effect of reporting biases led us to downgrade the quality of evidence for this effect from high to moderate. There was no significant difference in the rate of hospitalisations (rate ratio 0.79; 95% CI 0.55 to 1.13, very low quality evidence due to risk of bias, statistical imprecision and inconsistency). There was no significant difference in mortality between people on combined inhalers and those on LABA, from 10 studies on 10,680 participants (OR 0.92; 95% CI 0.76 to 1.11, downgraded to moderate quality evidence due to statistical imprecision). Pneumonia occurred more commonly in people randomised to combined inhalers, from 12 studies with 11,076 participants (OR 1.55; 95% CI 1.20 to 2.01, moderate quality evidence due to risk of bias in relation to attrition) with an annual risk of around 3% on LABA alone compared to 4% on combination treatment. There were no significant differences between the results for either exacerbations or pneumonia from trials adding different doses or types of inhaled corticosteroid. Secondary outcomes ICS/LABA was more effective than LABA alone in improving health-related quality of life measured by the St George's Respiratory Questionnaire (1.58 units lower with FPS; 2.69 units lower with BDF), dyspnoea (0.09 units lower with FPS), symptoms (0.07 units lower with BDF), rescue medication (0.38 puffs per day fewer with FPS, 0.33 puffs per day fewer with BDF), and forced expiratory volume in one second (FEV1) (70 mL higher with FPS, 50 mL higher with BDF). Candidiasis (OR 3.75) and upper respiratory infection (OR 1.32) occurred more frequently with FPS than SAL. We did not combine adverse event data relating to candidiasis for BDF studies as the results were very inconsistent. Authors' conclusions Concerns over the analysis and availability of data from the studies bring into question the superiority of ICS/LABA over LABA alone in preventing exacerbations. The effects on hospitalisations were inconsistent and require further exploration. There was moderate quality evidence of an increased risk of pneumonia with ICS/LABA. There was moderate quality evidence that treatments had similar effects on mortality. Quality of life, symptoms score, rescue medication use and FEV1 improved more on ICS/LABA than on LABA, but the average differences were probably not clinically significant for these outcomes. To an individual patient the increased risk of pneumonia needs to be balanced against the possible reduction in exacerbations. More information would be useful on the relative benefits and adverse event rates with combination inhalers using different doses of inhaled corticosteroids. Evidence from head-to-head comparisons is needed to assess the comparative risks and benefits of the different combination inhalers.

Coherent quantum phase slip

Abstract: The magnetic-flux analogue to coherent Josephson tunnelling of electric charge has been observed in a strongly disordered superconducting nanowire. Coherent quantum phase slip (CQPS) has not, until now, been observed experimentally. It is a phenomenon exactly dual to the Josephson effect, but whereas the latter is a coherent transfer of charges between superconducting contacts, CQPS is a coherent transfer of vortices or fluxes across a superconducting wire. This paper reports direct observation of CQPS in a strongly disordered indium oxide superconducting wire inserted in a loop; the effect manifests through the superposition of quantum states with different fluxes. The CQPS may — like the Josephson effect before it — lead to innovative applications in superconducting electronics and quantum metrology. A hundred years after the discovery of superconductivity, one fundamental prediction of the theory, coherent quantum phase slip (CQPS), has not been observed. CQPS is a phenomenon exactly dual1 to the Josephson effect; whereas the latter is a coherent transfer of charges between superconducting leads2,3, the former is a coherent transfer of vortices or fluxes across a superconducting wire. In contrast to previously reported observations4,5,6,7,8 of incoherent phase slip, CQPS has been only a subject of theoretical study9,10,11,12. Its experimental demonstration is made difficult by quasiparticle dissipation due to gapless excitations in nanowires or in vortex cores. This difficulty might be overcome by using certain strongly disordered superconductors near the superconductor–insulator transition. Here we report direct observation of CQPS in a narrow segment of a superconducting loop made of strongly disordered indium oxide; the effect is made manifest through the superposition of quantum states with different numbers of flux quanta13. As with the Josephson effect, our observation should lead to new applications in superconducting electronics and quantum metrology1,10,11.

Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe.

Abstract: Air samples were collected from 4 field sites in Europe: 2 sites from the UK, Hazelrigg (semi-rural) and Manchester (urban); 1 site from Ireland: Mace Head (rural); and 1 site from Norway: Kjeller (rural) Additionally, air samples were taken from indoor locations in Tromso, Norway Air samples were collected using high-volume air samplers employing sampling modules containing glass-fibre filters (GFFs, particle phase), and glass columns with a polyurethane foam (PUF)–XAD-2–PUF sandwich (gaseous phase) Typical outdoor air volumes required for the determination of per- and polyfluorinated alkyl substances (PFAS) ranged from 500–1800 m3 GFFs and PUF–XAD columns were analysed separately to obtain information on phase partitioning All air samples were analysed for volatile, neutral PFAS, with selected GFF samples halved for analysis of both neutral and airborne particle-bound ionic PFAS Volatile PFAS were extracted from air samples by cold-column immersion with ethyl acetate, and were analysed by gas chromatography–mass spectrometry in the positive chemical ionisation mode (GC–PCI–MS) Ionic PFAS were extracted from GFFs by sonication in methanol, and were analysed by liquid chromatography–time-of-flight–mass spectrometry (LC–TOF–MS) using electrospray ionisation in the negative ion mode (ESI−) Perfluorooctanoate (PFOA) was often the predominant analyte found in the particulate phase at concentrations ranging from 1–818 pg m−3, and 8:2 fluorotelomer alcohol (FTOH) and 6:2 FTOH were the prevailing analytes found in the gas phase, at 5–243 pg m−3 and 5–189 pg m−3, respectively These three PFAS were ubiquitous in air samples Many other PFAS, both neutral and ionic, were also present, and levels of individual analytes were in the 1–125 pg m−3 range Levels of some PFAS exceeded those of traditional persistent organic pollutants (POPs) In this study, the presence of 12:2 FTOH and fluorotelomer olefins (FTolefins), and ionic PFAS other than perfluorooctane sulfonate (PFOS) and PFOA, are reported in air samples for the first time Concentrations of neutral PFAS were several orders of magnitude higher in indoor air than outdoor air, making homes a likely important diffuse source of PFAS to the atmosphere Our repeated findings of non-volatile ionic PFAS in air samples raises the possibility that they might directly undergo significant atmospheric transport on particles away from source regions, and more atmospheric measurements of ionic PFAS are strongly recommended

Particle physics models of inflation and curvaton scenarios

Abstract: We review the particle theory origin of inflation and curvaton mechanisms for generating large scale structures and the observed temperature anisotropy in the cosmic microwave background (CMB) radiation. Since inflaton or curvaton energy density creates all matter, it is important to understand the process of reheating and preheating into the relevant degrees of freedom required for the success of Big Bang Nucleosynthesis. We discuss two distinct classes of models, one where inflaton and curvaton belong to the hidden sector, which are coupled to the Standard Model gauge sector very weakly. There is another class of models of inflaton and curvaton, which are embedded within Minimal Supersymmetric Standard Model (MSSM) gauge group and beyond, and whose origins lie within gauge invariant combinations of supersymmetric quarks and leptons. Their masses and couplings are all well motivated from low energy physics, therefore such models provide us with a unique opportunity that they can be verified/falsified by the CMB data and also by the future collider and non-collider based experiments. We then briefly discuss stringy origin of inflation, alternative cosmological scenarios, and bouncing universes.