National Jewish Health

About: National Jewish Health is a healthcare organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Asthma & T cell. The organization has 883 authors who have published 833 publications receiving 79201 citations. The organization is also known as: National Jewish Medical and Research Center.

Psychological Perspectives on Pediatric Eosinophilic Esophagitis

Abstract: Eosinophilic esophagitis (EoE) is a recently described disorder marked clinically by symptoms of upper gastrointestinal distress and by histological evidence of increased eosinophils in the esophagus. Although EoE has been reported in individuals across the lifespan, the disease has been most comprehensively described in children and adolescents. In addition to further clarifications of EoE symptom presentation, current studies are investigating the pathophysiology of the disease as well as the effectiveness and outcome of treatments. Attention has now turned to the impact of the disease on the quality of life and psychosocial functioning of children and their families. Since investigation of psychological aspects of EoE is in its infancy, little systematic information is available at this time. Nevertheless, with some information from recent and current studies as well as from clinical experience, it is possible to pose key questions about the impact of the symptoms and the treatments specific to EoE on quality of life for children and adolescents. Further, a great deal of information is available regarding psychosocial effects of various chronic illnesses on children, and extrapolations from previous studies are informative regarding likely effects on youth of all ages with EoE. This chapter will review what is known about the impact of EoE on quality of life and psychosocial adjustment, discuss the bidirectional effects of pediatric chronic illness characteristics, psychosocial functioning, and quality of life, and examine the role of coping and adaptation in relation to psychosocial functioning and quality of life.

AMID protein, nucleic acid molecules, and uses thereof

Abstract: Described here is the cloning and characterization of a novel AIF homologous molecule designated AMID, which is co-localized with mitochondria, and which induces cell death with characteristic apoptotic morphology, independent of caspase activation and p53. Bcl2. Disclosed herein are AMID proteins, fragments and homologues, as well as nucleic acid molecules encoding such proteins, and methods of making and using the same.

Idiopathic pulmonary fibrosis co-morbidity: thromboembolic disease and coronary artery disease

Abstract: Over the past decade, it has been increasingly recognized that patients with idiopathic pulmonary fibrosis (IPF) are at risk of both venous thromboembolic disease (VTE) and coronary artery disease (CAD). When present, these co-morbid conditions negatively affect outcomes. For this disease without effective therapy to improve survival, increased diagnosis and treatment of these co-morbid processes may improve outcomes. Better understanding of the mechanisms that place IPF patients at increased risk of VTE and CAD may also ultimately lead to novel therapeutic interventions.