Institution
Oregon Health & Science University
Education•Portland, Oregon, United States•
About: Oregon Health & Science University is a education organization based out in Portland, Oregon, United States. It is known for research contribution in the topics: Population & Health care. The organization has 30245 authors who have published 65190 publications receiving 3302774 citations. The organization is also known as: University of Oregon Health Sciences Center & Oregon Health Sciences University.
Topics: Population, Health care, Medicine, Cancer, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: Unilateral sclerosis of the trabecular meshwork produces sustained elevation of intraocular pressure in rats with optic nerve damage that in many ways resembles that seen in human glaucoma.
511 citations
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TL;DR: Clinicians should refrain from routine, immediate lumbar imaging in patients with acute or subacute low-back pain and without features suggesting a serious underlying condition, as results are most applicable to acute orSubacuteLow-Back pain assessed in primary-care settings.
510 citations
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TL;DR: It is concluded that 5-HT inputs may derive from local5-HT neurons in the pericoerulear area of the nucleus locus coeruleus, and the dorsal raphe does not provide the robust 5- HT innervation found in the LC.
Abstract: Tract-tracing and electrophysiology studies have revealed that major inputs to the nucleus locus coeruleus (LC) are found in two structures, the nucleus paragigantocellularis (PGi) and the perifascicular area of the nucleus prepositus hypoglossi (PrH), both located in the rostral medulla. Minor afferents to LC were found in the dorsal cap of the paraventricular hypothalamus and spinal lamina X. Recent studies have also revealed limited inputs from two areas nearby the LC, the caudal midbrain periaqueductal gray (PAG) and the ventromedial pericoerulear region. The pericoeruleus may provide a local circuit interface to LC neurons. Recent electron microscopic analyses have revealed that LC dendrites extend preferentially into the rostromedial and caudal juxtaependymal pericoerulear regions. These extracoerulear LC dendrites may receive afferents in addition to those projecting to LC proper. However, single-pulse stimulation of inputs to such dendritic regions reveals little or no effect on LC neurons. Double-labeling studies have revealed that a variety of neurotransmitters impinging on LC neurons originate in its two major afferents, PGi and PrH. The LC is innervated by PGi neurons that stain for markers of adrenalin, enkephalin or corticotropin-releasing factor. Within PrH, large proportions of LC-projecting neurons stained for GABA or met-enkephalin. Finally, in contrast to previous conclusions, the dorsal raphe does not provide the robust 5-HT innervation found in the LC. We conclude that 5-HT inputs may derive from local 5-HT neurons in the pericoerulear area. Neuropharmacology experiments revealed that the PGi provides a potent excitatory amino acid (EAA) input to the LC, acting primarily at non-NMDA receptors in the LC. Other studies indicated that this pathway mediates certain sensory responses of LC neurons. NMDA-mediated sensory responses were also revealed during local infusion of magnesium-free solutions. Finally, adrenergic inhibition of LC from PGi could also be detected in nearly every LC neuron tested when the EAA-mediated excitation is first eliminated. In contrast to PGi, the PrH potently and consistently inhibited LC neurons via a GABAergic projection acting at GABAA receptors within LC. Such PrH stimulation also potently attenuated LC sensory responses. Finally, afferents to PGi areas that also contain LC-projecting neurons were identified. Major inputs were primarily autonomic in nature, and included the caudal medullary reticular formation, the parabrachial and Kolliker-Fuse nuclei, the PAG, NTS and certain hypothalamic areas.(ABSTRACT TRUNCATED AT 400 WORDS)
510 citations
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University of British Columbia1, National Institutes of Health2, Leidos3, University of Würzburg4, University of Barcelona5, University of Nebraska Medical Center6, University of Oslo7, Oregon Health & Science University8, Bosch9, Cleveland Clinic10, City of Hope National Medical Center11, University of Arizona12
TL;DR: The Lymphoma/Leukemia Molecular Profiling Project's Lymph2Cx assay is a parsimonious digital gene expression (NanoString)-based test for COO assignment in formalin-fixed paraffin-embedded tissue (FFPET) that is accurate, robust, and robust, with >95% concordance of COO assignments between 2 independent laboratories.
508 citations
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TL;DR: It is demonstrated that the tendons associated with the axial skeleton derive from a heretofore unappreciated, fourth compartment of the somites, and may reveal a general mechanism for the specification of other somitic subcompartments.
508 citations
Authors
Showing all 30591 results
Name | H-index | Papers | Citations |
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Gordon B. Mills | 187 | 1273 | 186451 |
David W. Bates | 159 | 1239 | 116698 |
David Eisenberg | 156 | 697 | 112460 |
Christopher K. Glass | 154 | 427 | 108997 |
Xiang Zhang | 154 | 1733 | 117576 |
Howard I. Scher | 151 | 944 | 101737 |
David J.P. Barker | 148 | 446 | 99373 |
Steven L. Salzberg | 147 | 407 | 231756 |
Richard A. Deyo | 139 | 483 | 86769 |
Christopher D.M. Fletcher | 138 | 674 | 82484 |
Richard J. Johnson | 137 | 880 | 72201 |
Jay Shendure | 135 | 466 | 76953 |
John D. Scott | 135 | 625 | 83878 |
Douglas C. Wallace | 134 | 475 | 72035 |
Joel N. Hirschhorn | 133 | 431 | 101061 |