Showing papers by "Romanian Academy published in 2009"

Basement membranes in skin: unique matrix structures with diverse functions?

Abstract: The view of extracellular matrix (ECM) has evolved from a merely scaffolding and space filling tissue element to an interface actively controlling cellular activities and tissue functions. A highly specialized form of ECM is the basement membrane (BM), an ubiquitous sheet-like polymeric structure composed of a set of distinct glycoproteins and proteoglycans. In this review we are largely focusing on function and assembly of BM in skin (1) at the dermo-epidermal interface and (2) in the resident micro-vasculature. The role of the non-polymeric components perlecan and particularly nidogen is exemplified by reviewing experiments based on genetic approaches and adequate experimental skin models in vivo and in vitro. While in mice total deficiency of one of these components is eventually developmentally lethal, the severity of the defects varies drastically between tissues and also the skin models recapitulating BM formation in vitro. There is accumulating evidence that this relies on the mechanical properties, the molecular composition of the BM, the adjacent ECM or connective tissue, the dynamics of molecular assembly, and ‘minor’ tissue-specific modifier or adapter components. Though the role of nidogen or perlecan is still remaining a controversial issue, the statements ‘being essential for BM/or not’ should be consequently referred to the developmental, tissue, and functional (e.g., repair) context.

3D Ordered Gold Strings by Coating Nanoparticles with Mesogens

Abstract: Gold nanoparticles covered with a nematic liquid-crystal ligand laterally attached via a thioalkyl spacer and a thioalkane “diluent” exhibit 3D ordering in strings jacketed by the mesogens with controllable interparticle spacing. The particles form rhombohedral, hexagonal, and rectangular columnar superlattices, not the usual packing modes of spheres.

Topology and geometry of cohomology jump loci

Abstract: We elucidate the key role played by formality in the theory of characteristic and resonance varieties. We define relative characteristic and resonance varieties, V_k and R_k, related to twisted group cohomology with coefficients of arbitrary rank. We show that the germs at the origin of V_k and R_k are analytically isomorphic, if the group is 1-formal; in particular, the tangent cone to V_k at 1 equals R_k. These new obstructions to 1-formality lead to a striking rationality property of the usual resonance varieties. A detailed analysis of the irreducible components of the tangent cone at 1 to the first characteristic variety yields powerful obstructions to realizing a finitely presented group as the fundamental group of a smooth, complex quasi-projective algebraic variety. This sheds new light on a classical problem of J.-P. Serre. Applications to arrangements, configuration spaces, coproducts of groups, and Artin groups are given.

Uniform solutions to SAT and Subset Sum by spiking neural P systems

Abstract: We continue the investigations concerning the possibility of using spiking neural P systems as a framework for solving computationally hard problems, addressing two problems which were already recently considered in this respect: $${\tt Subset}\,{\tt Sum}$$ and $${\tt SAT}.$$ For both of them we provide uniform constructions of standard spiking neural P systems (i.e., not using extended rules or parallel use of rules) which solve these problems in a constant number of steps, working in a non-deterministic way. This improves known results of this type where the construction was non-uniform, and/or was using various ingredients added to the initial definition of spiking neural P systems (the SN P systems as defined initially are called here "standard"). However, in the $${\tt Subset}\,{\tt Sum}$$ case, a price to pay for this improvement is that the solution is obtained either in a time which depends on the value of the numbers involved in the problem, or by using a system whose size depends on the same values, or again by using complicated regular expressions. A uniform solution to 3- $${\tt SAT}$$ is also provided, that works in constant time.

Koszul Cohomology and Algebraic Geometry

Abstract: The systematic use of Koszul cohomology computations in algebraic geometry can be traced back to the foundational work of Mark Green in the 1980s. Green connected classical results concerning the ideal of a projective variety with vanishing theorems for Koszul cohomology. Green and Lazarsfeld also stated two conjectures that relate the Koszul cohomology of algebraic curves with the existence of special divisors on the curve. These conjectures became an important guideline for future research. In the intervening years, there has been a growing interaction between Koszul cohomology and algebraic geometry. Green and Voisin applied Koszul cohomology to a number of Hodge-theoretic problems, with remarkable success. More recently, Voisin achieved a breakthrough by proving Green's conjecture for general curves; soon afterwards, the Green-Lazarsfeld conjecture for general curves was proved as well. This book is primarily concerned with applications of Koszul cohomology to algebraic geometry, with an emphasis on syzygies of complex projective curves. The authors' main goal is to present Voisin's proof of the generic Green conjecture, and subsequent refinements. They discuss the geometric aspects of the theory and a number of concrete applications of Koszul cohomology to problems in algebraic geometry, including applications to Hodge theory and to the geometry of the moduli space of curves.

Topology and geometry of cohomology jump loci

Abstract: We elucidate the key role played by formality in the theory of characteristic and resonance varieties. We define relative characteristic and resonance varieties, V_k and R_k, related to twisted group cohomology with coefficients of arbitrary rank. We show that the germs at the origin of V_k and R_k are analytically isomorphic, if the group is 1-formal; in particular, the tangent cone to V_k at 1 equals R_k. These new obstructions to 1-formality lead to a striking rationality property of the usual resonance varieties. A detailed analysis of the irreducible components of the tangent cone at 1 to the first characteristic variety yields powerful obstructions to realizing a finitely presented group as the fundamental group of a smooth, complex quasi-projective algebraic variety. This sheds new light on a classical problem of J.-P. Serre. Applications to arrangements, configuration spaces, coproducts of groups, and Artin groups are given.

On 3D Reconstruction of Coronal Mass Ejections: I. Method Description and Application to SECCHI-COR Data

Abstract: The data from SECCHI-COR1 and SECCHI-COR2 coronagraphs onboard the STEREO mission, which was launched in October 2006, provide us with the first-ever stereoscopic images of the Sun’s corona. These observations were found to be useful in inferring the three-dimensional structure of coronal mass ejections (CMEs) and their propagation direction in space. We apply four methods for reconstructing CMEs: i) Forward modeling technique; ii) Local correlation tracking (to identify the same feature in COR Ahead and COR Behind images) plus tie-point reconstruction technique; iii) Center of mass of the structures in a given epipolar plane plus tie-point reconstruction technique; iv) Polarization ratio technique. The four techniques are applied to three structured CMEs observed by COR1 and COR2 instruments, respectively, on 15 May 2007, 31 August 2007, and 25 March 2008. A comparison of the results obtained from the application of the four reconstruction algorithms is presented and discussed.

Stochastic Porous Media Equations and Self-Organized Criticality

Abstract: The existence and uniqueness of nonnegative strong solutions for stochastic porous media equations with noncoercive monotone diffusivity function and Wiener forcing term is proven. The finite time extinction of solutions with high probability is also proven in 1-D. The results are relevant for self-organized criticality behavior of stochastic nonlinear diffusion equations with critical states.

Brain renin-angiotensin system in cognitive function: pre-clinical findings and implications for prevention and treatment of dementia.

Abstract: Biochemical, physiological and functional studies suggest that the brain renin-angiotensin system (RAS) is regulated independently of the peripheral RAS. Also, all enzymes and peptides necessary for the biosynthesis of various angiotensins have been recognized within the central nervous system. There are divergent opinions concerning the localization of the different components of this system which is not fully understood. It is believed that central actions of angiotensins are not exclusively associated with their traditional roles, many studies showing that central angiotensins are also involved in learning and memory processes. Moreover, clinical trials and studies on animal models suggest that pharmacological manipulation of angiotensin ligands may be of clinical importance in slowing or even stopping the cognitive deterioration seen in vascular dementia and Alzheimer's disease.

Proper Motions in Kapteyn Selected Area 103: A Preliminary Orbit for the Virgo Stellar Stream

Abstract: We present absolute proper motions in Kapteyn Selected Area (SA) 103. This field is located 7° west of the center of the Virgo Stellar Stream (VSS), and has a well-defined main sequence representing the stream. In SA 103, we identify one RR Lyrae star as a member of the VSS, according to its metallicity, radial velocity, and distance. VSS candidate turnoff and subgiant stars have proper motions consistent with that of the RR Lyrae star. The three-dimensional velocity data imply an orbit with a pericenter of ~11 kpc and an apocenter of ~90 kpc. Thus, the VSS comprises tidal debris found near the pericenter of a highly destructive orbit. Examining the six globular clusters at distances larger than 50 kpc from the Galactic center, and the proposed orbit of the VSS, we find one tentative association, NGC 2419. We speculate that NGC 2419 is possibly the nucleus of a disrupted system of which the VSS is a part.

The disc-jet coupling in the neutron star X-ray binary Aquila X-1

Abstract: We study the accretion/ejection processes (i.e. disc/jet coupling) in the neutron star X-ray binary Aquila X-1 via a multiwavelength approach. We use in the radio band the publicly available Very Large Array archive containing observations of the object between 1986 and 2005, in the X-ray band the archival Rossi X-ray Timing Explorer data (Proportional Counter Array and High Energy X-ray Timing Experiment) between 1997 and 2008, and in optical (R band) observations with the Small and Moderate Aperture Research Telescope System recorded between 1998 and 2007. In the combined data set, we find three outbursts for which quasi-simultaneous radio, optical (R band) and X-ray data exist and focus on them to some extent. We provide evidence that the disc/jet coupling in Aquila X-1 is similar to what has been observed in black hole X-ray binaries, at least from the point of view of the behaviour in the hardness-intensity diagrams (the hysteresis effect included), when the phenomenology of the jet is taken into account. Although based on a very small number of observations, a radio/X-ray correlation seems to exist for this system, with a slope of α= 0.40 ± 0.07 (Fradio∝FαX), which is different than the slope of α= 1.40 ± 0.25 found for another atoll source, 4U 1728−34, but interestingly enough is relatively close to the values obtained for several black hole X-ray binaries. No significant correlation is found between the radio and optical (R-band) emissions. We also report a significant drop in the radio flux from Aquila X-1 above an X-ray flux of ∼5 × 10−9 erg cm−2 s−1. This behaviour, also reported in the neutron star X-ray binary 4U 1728−34, may be analogous to the suppression of radio emission in black hole X-ray binaries in bright, soft X-ray states. It suggests that from this point of view neutron star X-ray binaries can mimic the behaviour of black hole X-ray binaries in suppressing the jet in soft/disc-dominated X-ray states.

A PDE variational approach to image denoising and restoration

Abstract: In this paper we discuss a general variational model for image restoration based on the minimization of a convex functional of gradient under minimal growth conditions. This approach is related to minimization in bounded variation norm and has a smoothing effect on degraded image while preserving the edge features.

Snow pack in the Romanian Carpathians under changing climatic conditions

Abstract: Snow pack characteristics and duration are considered to be key indicators of climate change in mountain regions, especially during the winter season (herein considered to last from the 1st of November to the 30th of April). Deviations recorded in the regime of the main explanatory variables of snow pack changes (i.e. temperature and precipitation) offer useful information on winter climate variability, in the conditions of the winter warming trend already seen in some areas of the Romanian Carpathians. The present work focuses on changes and trends in snow pack characteristics and its related parameters, registered at the 15 weather stations located in the alpine, sub-alpine and forest belts in all the three Romanian Carpathian branches (>1,000 m) over the 1961–2003 period. Changes in the snow pack regime were investigated in relation with the modifications of winter temperature and precipitation having been detected mostly at the end of the twentieth century. A winter standardized index was calculated to group winters over the 43-year period into severity classes and detect the respective changes. Links between the number of snow cover days and seasonal NAO index were also statistically analysed in this study. The general results show large regional and altitudinal variations and the complex character of the climate in the Romanian Carpathians, leading to the idea of an ongoing warming process associated with a lower incidence of snow cover, affecting to a large extent the forested mountain areas located below 1,600–1,700 m altitude. Also negative and weak correlations were found, particularly over the December–March interval, between the number of snow cover days and seasonal NAO index values.

Bounded symbols and reproducing kernel thesis for truncated Toeplitz operators

Abstract: Compressions of Toeplitz operators to coinvariant subspaces of $H^2$ are called truncated Toeplitz operators. We study two questions related to these operators. The first, raised by Sarason, is whether boundedness of the operator implies the existence of a bounded symbol; the second is the reproducing kernel thesis. We show that in general the answer to the first question is negative, and we exhibit some classes of spaces for which the answers to both questions are positive.

Community Perception of Water Quality in a Mining-Affected Area: A Case Study for the Certej Catchment in the Apuseni Mountains in Romania

Abstract: Mining-contaminated sites and the affected communities at risk are important issues on the agenda of both researchers and policy makers, particularly in the former communist block countries in Eastern Europe. Integrated analyses and expert based assessments concerning mining affected areas are important in providing solid policy guidelines for environmental and social risk management and mitigation. Based on a survey for 103 households conducted in a former mining site in the Certej Catchment of the Apuseni Mountains, western Romania, this study assesses local communities’ perceptions on the quality of water in their living area. Logistic regression was used to examine peoples’ perception on the quality of the main river water and of the drinking water based on several predictors relating to social and economic conditions. The results from the perception analysis were then compared with the measurements of heavy metal contamination of the main river and drinking water undertaken in the same study area. The findings indicate that perception and measurement results for the water quality in the Certej Catchment are convergent, suggesting an obvious risk that mining activities pose on the surface water. However, the perception on drinking water quality was little predicted by the regression model and does not seem to be so much related to mining as to other explanatory factors, such as special mineralogy of rock and soils or improper water treatment infrastructure, facts suggested by the measurements of the contaminants. Discussion about the implications of these joint findings for risk mitigation policies completes this article.

Environmental correlates of species richness of European springtails (Hexapoda: Collembola).

Abstract: Our knowledge about environmental correlates of the spatial distribution of animal species stems mostly from the study of well known vertebrate and a few invertebrate taxa. The poor spatial resolution of faunistic data and undersampling prohibit detailed spatial modeling for the vast majority of arthropods. However, many such models are necessary for a comparative approach to the impact of environmental factors on the spatial distribution of species of different taxa. Here we use recent compilations of species richness of 35 European countries and larger islands and linear spatial autocorrelation modeling to infer the influence of area and environmental variables on the number of springtail (Collembola) species in Europe. We show that area, winter length and annual temperature difference are major predictors of species richness. We also detected a significant negative longitudinal gradient in the number of springtail species towards Eastern Europe that might be caused by postglacial colonization. In turn, environmental heterogeneity and vascular plant species richness did not significantly contribute to model performance. Contrary to theoretical expectations, climate and longitude corrected species–area relationships of Collembola did not significantly differ between islands and mainlands.

Green's Conjecture for curves on arbitrary K3 surfaces

Abstract: Green's Conjecture predicts than one can read off special linear series on an algebraic curve, by looking at the syzygies of its canonical embedding. We extend Voisin's results on syzygies of K3 sections, to the case of K3 surfaces with arbitrary Picard lattice. This, coupled with results of Voisin and Hirschowitz-Ramanan, provides a complete solution to Green's Conjecture for smooth curves on arbitrary K3 surfaces.

Hpv particles and uses thereof

Abstract: The invention relates to modified HPV particles that can be used therapeutically. Modified HPV particles may be used to deliver therapeutic agents, including siRNA molecules. Modified HPV particles may be used for the treatment of diseases or conditions of mucosal tissue, including HPV (human papilloma virus) infection and HPV-related tumors.