Institution
Southern Illinois University School of Medicine
Education•Springfield, Illinois, United States•
About: Southern Illinois University School of Medicine is a education organization based out in Springfield, Illinois, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 3747 authors who have published 5977 publications receiving 209115 citations. The organization is also known as: SIU School of Medicine.
Topics: Population, Cancer, Ototoxicity, Receptor, Health care
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated that griffithsin inhibits HSV-2 by a unique mechanism of blocking cell-to-cell spread and support its further development for HIV and HSv-2 prevention.
Abstract: Griffithsin, which binds N-linked glycans on gp120 to prevent HIV entry, has the most potent HIV-1 inhibitory activity described for any antiviral lectin and is being developed for topical preexposure prophylaxis. The current studies were designed to further assess its potential by exploring its activity against herpes simplex virus 2 (HSV-2), a cofactor for HIV acquisition, in vitro and in a murine model. Safety was evaluated by examining its impact on epithelial barrier integrity in polarized cultures and testing whether repeated intravaginal dosing potentiates the susceptibility of mice to genital herpes. Griffithsin displayed modest inhibitory activity against HSV-2 if present during viral entry but completely blocked plaque formation if present postentry, reduced plaque size, and prevented cell-to-cell spread. These in vitro findings translated to significant protection against genital herpes in mice treated with 0.1% griffithsin gel. Griffithsin, but not placebo gel, prevented viral spread (visualized with a luciferase-expressing virus), significantly reduced disease scores, and resulted in greater survival (P < 0.05, log rank test). Protection persisted when HSV-2 was introduced in seminal plasma. Although griffithsin triggered a small decline in transepithelial electrical resistance in polarized cultures, this did not translate to any significant increase in the ability of HIV to migrate from the apical to the basolateral chamber nor to an increase in susceptibility to HSV-2 in mice treated with griffithsin gel for 7 days. These findings demonstrate that griffithsin inhibits HSV-2 by a unique mechanism of blocking cell-to-cell spread and support its further development for HIV and HSV-2 prevention.
101 citations
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TL;DR: Age-related loss of GABA-mediated inhibition in the CIC of Fischer-344 rats is not attributable to changes in uptake or degradation of GABA, but may be related loss of biosynthetic capacity.
101 citations
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TL;DR: Physical activity correlates and barriers among head and neck cancer patients showed that the strongest independent correlates of physical activity were social cognitive and treatment-related (i.e., symptom index).
Abstract: Purpose
Our study purpose was to determine physical activity correlates and barriers among head and neck cancer patients
101 citations
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TL;DR: In the absence of GH signaling, the secretory activity of visceral fat is profoundly altered and unexpectedly promotes enhanced insulin sensitivity and reducing adiposity by calorie restriction fails to improve insulin signaling or further extend longevity in these animals.
Abstract: Mice with targeted deletion of the growth hormone receptor (GHRKO mice) are growth hormone (GH) resistant, small, obese, hypoinsulinemic, highly insulin sensitive and remarkably long-lived. To elucidate the unexpected coexistence of adiposity with improved insulin sensitivity and extended longevity, we examined effects of surgical removal of visceral (epididymal and perinephric) fat on metabolic traits related to insulin signaling and longevity. Comparison of results obtained in GHRKO mice and in normal animals from the same strain revealed disparate effects of visceral fat removal (VFR) on insulin and glucose tolerance, adiponectin levels, accumulation of ectopic fat, phosphorylation of insulin signaling intermediates, body temperature, and respiratory quotient (RQ). Overall, VFR produced the expected improvements in insulin sensitivity and reduced body temperature and RQ in normal mice and had opposite effects in GHRKO mice. Some of the examined parameters were altered by VFR in opposite directions in GHRKO and normal mice, and others were affected in only one genotype or exhibited significant genotype × treatment interactions. Functional differences between visceral fat of GHRKO and normal mice were confirmed by measurements of adipokine secretion, lipolysis, and expression of genes related to fat metabolism. We conclude that in the absence of GH signaling, the secretory activity of visceral fat is profoundly altered and unexpectedly promotes enhanced insulin sensitivity. The apparent beneficial effects of visceral fat in GHRKO mice may also explain why reducing adiposity by calorie restriction fails to improve insulin signaling or further extend longevity in these animals.
101 citations
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TL;DR: The significant increase in the cure of tumor-bearing mice in the nab-paclitaxel/bevacizumab combined group compared with mice treated with single drugs strongly advocates for implementing such strategy in clinics.
101 citations
Authors
Showing all 3778 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jatin P. Shah | 119 | 725 | 45680 |
Harold G. Koenig | 99 | 678 | 46742 |
Chawnshang Chang | 97 | 534 | 35629 |
Richard J. K. Taylor | 91 | 1543 | 43893 |
Martin R. Farlow | 82 | 381 | 26820 |
David A. D'Alessio | 80 | 272 | 22955 |
Dirk R. Larson | 79 | 271 | 24067 |
Andrzej Bartke | 78 | 516 | 22865 |
Michael Brenner | 76 | 564 | 22010 |
Arnulf Stenzl | 73 | 791 | 23285 |
Wolfgang H. Dillmann | 72 | 200 | 17595 |
Michael Bonkowski | 66 | 279 | 13851 |
Jacob E. Friedman | 65 | 191 | 12485 |
Richard Salvi | 65 | 447 | 16289 |
Russell Noyes | 63 | 229 | 12790 |