Showing papers by "United States Department of the Army published in 1988"

Estimated prevalence of anabolic steroid use among male high school seniors

Abstract: The use of anabolic-androgenic steroids (AS) is perceived by the media, by segments of the sports medicine and athletic communities, and by the public to have grown to epidemic proportions. Unfortunately, the incidence and prevalence of AS use among elite, amateur, and recreational athletes is poorly documented. This study was designed to help identify AS use patterns among the male portion of the general adolescent population. The overall participation rate on a schoolwide basis was 68.7% and on an individual basis reached 50.3%. Participants in this investigation were 12th-grade male students (N = 3403) in 46 private and public high schools across the nation who completed a questionnaire that established current or previous use of AS as well as user and nonuser characteristics. Results indicate that 6.6% of 12th grade male students use or have used AS and that over two thirds of the user group initiated use when they were 16 years of age or younger. Approximately 21% of users reported that a health professional was their primary source. The evidence indicates that educational intervention strategies should begin as early as junior high school; the intervention should not be directed only toward those individuals who participate in school-based athletics. (JAMA1988;260:3441-3445)

Erotophobia‐erotophilia as a dimension of personality

Abstract: This review discusses the measurement, antecedents, and consequents of erotophobia‐erotophilia—the disposition to respond to sexual cues along a negative‐positive dimension of affect and evaluation. Test construction procedures which resulted in a 21‐item measure of this personality construct are reported. Evidence indicates that the measure is internally consistent, shows acceptable degrees of convergent and discriminant validity, and is correlated as expected with related constructs such as authoritarianism, adherence to traditional sex roles, indices of value orthodoxy, and various measures of sex‐related evaluations. Retrospective surveys and group contrasts suggest that erotophobia‐erotophilia is a learned disposition based on one's exposure to sex‐related restrictiveness and punishment during socialization. Consequents of erotophobia‐erotophilia involve avoidance versus approach responses to sexuality in a wide range of situations; scores on this test predict differential sexual experience, response...

Protection against Japanese Encephalitis by Inactivated Vaccines

Abstract: Encephalitis caused by Japanese encephalitis virus occurs in annual epidemics throughout Asia, making it the principal cause of epidemic viral encephalitis in the world. No currently available vaccine has demonstrated efficacy in preventing this disease in a controlled trial. We performed a placebo-controlled, blinded, randomized trial in a northern Thai province, with two doses of monovalent (Nakayama strain) or bivalent (Nakayama plus Beijing strains) inactivated, purified Japanese encephalitis vaccine made from whole virus derived from mouse brain. We examined the effect of these vaccines on the incidence and severity of Japanese encephalitis and dengue hemorrhagic fever, a disease caused by a closely related flavivirus. Between November 1984 and March 1985, 65,224 children received two doses of monovalent Japanese encephalitis vaccine (n = 21,628), bivalent Japanese encephalitis vaccine (n = 22,080), or tetanus toxoid placebo (n = 21,516), with only minor side effects. The cumulative attack rate for encephalitis due to Japanese encephalitis virus was 51 per 100,000 in the placebo group and 5 per 100,000 in each vaccine group. The efficacy in both vaccine groups combined was 91 percent (95 percent confidence interval, 70 to 97 percent). Attack rates for dengue hemorrhagic fever declined, but not significantly. The severity of cases of dengue was also reduced. We conclude that two doses of inactivated Japanese encephalitis vaccine, either monovalent or bivalent, protect against encephalitis due to Japanese encephalitis virus and may have a limited beneficial effect on the severity of dengue hemorrhagic fever.

Operation Everest. II: Nutrition and body composition

Abstract: Progressive body weight loss occurs during high mountain expeditions, but whether it is due to hypoxia, inadequate diet, malabsorption, or the multiple stresses of the harsh environment is unknown. To determine whether hypoxia due to decompression causes weight loss, six men, provided with a palatable ad libitum diet, were studied during progressive decompression to 240 Torr over 40 days in a hypobaric chamber where hypoxia was the major environmental variable. Caloric intake decreased 43.0% from 3,136 to 1,789 kcal/day (P less than 0.001). The percent carbohydrate in the diet decreased from 62.1 to 53.2% (P less than 0.001). Over the 40 days of the study the subjects lost 7.4 +/- 2.2 (SD) kg and 1.6% (2.5 kg) of the total body weight as fat. Computerized tomographic scans indicated that most of the weight loss was derived from fat-free weight. The data indicated that prolonged exposure to the increasing hypoxia was associated with a reduction in carbohydrate preference and body weight despite access to ample varieties and quantities of food. This study suggested that hypoxia can be sufficient cause for the weight loss and decreased food consumption reported by mountain expeditions at high altitude.

Radiation effects on microelectronics in space

Abstract: The basic mechanisms of space radiation effects on microelectronics are reviewed. Topics discussed include the effects of displacement damage and ionizing radiation on devices and circuits, single-event phenomena, dose enhancement, radiation effects on optoelectronic devices and passive components, hardening approaches, and simulation of the space radiation environment. A summary of damage mechanisms that can cause temporary or permanent failure of devices and circuits operating in space is presented. >

Three-dimensional shape analysis using moments and Fourier descriptors

Abstract: A procedure for using moment-based feature vectors to identify a three-dimensional object from a two-dimensional image recorded at an arbitrary viewing angle and range is presented. A moment form called standard moments, rather than the usual moment invariants, is considered. A standard six-airplane experiment was used to compare different techniques. Fourier descriptors and moment invariants were both compared to the present scheme for normalized moments. Various experiments were conducted using mixtures of silhouette and boundary moments and different normalization techniques. Standard moments gave slightly better results than Fourier descriptors for this experiment; both of these techniques were much better than moment invariants. >

Synergistic Interactions of Anti-NS1 Monoclonal Antibodies Protect Passively Immunized Mice from Lethal Challenge with Dengue 2 Virus

Abstract: Summary Non-neutralizing, serotype-specific anti-NS1 monoclonal antibodies partially protected passively immunized mice from lethal dengue 2 virus intracerebral challenge. There was no apparent correlation between complement-fixing activity and protective capacity among individual anti-NS1 monoclonal antibodies. Immunization with specific combinations of non-protective or partially protective antibodies resulted in prolonged survival or reduced mortality. Solid protection, equal to that achieved after immunization with neutralizing polyclonal antibody, was achieved only with an antibody pair which individually fixed complement to high titre with homologous virus. Some groups of mice had increased morbidity after immunization with combinations of protective monoclonal antibodies that bind to overlapping epitopes. These results may affect the design of recombinant dengue vaccines which may require the inclusion of serotype-specific antigenic domains.

A heat shock operon in Coxiella burnetti produces a major antigen homologous to a protein in both mycobacteria and Escherichia coli.

Abstract: A gene library from the DNA of Coxiella burnetii has been constructed in the cosmid vector pHC79. A particular clone, pJB196, reacted strongly with Coxiella-specific antibodies elicited in a number of different species of animals. This clone produced two abundant C. burnetii-specific polypeptides, a 14-kilodalton nonimmunoreactive protein and a 62-kilodalton immunoreactive protein. Sequencing identified two open reading frames, encoding polypeptides of 10.5 and 58.3 kilodaltons. The only transcriptional control element observed on the 5' side of the initiation codon resembled a heat shock promoter. This heat shock promoter was functionally regulated in Escherichia coli, since both proteins were produced by growth conditions at 37 degrees C and neither protein was detected at 23 degrees C. There were four sequences from the literature that were highly homologous (greater than 50%) to the 62-kilodalton protein from C. burnetii. Three were from Mycobacterium species and represent the immunodominant antigen of this genus. The other was from E. coli, detected as a gene that complements or suppresses a temperature-sensitive RNase activity. Since the recombinant protein was immunogenic, it may serve as an efficacious vaccine against C. burnetii and other pathogenic microorganisms that express the conserved antigen.

Numerical simulations of the profile properties of undeformed first-year sea ice during the growth season

Abstract: A model is presented for estimating salinity profiles for the first-year sea ice during the growth season, in which ice growth equations were coupled with salt entrapment and brine drainage relations to obtain the relationship between the initial ice salinity and the ice-growth velocity and seawater salinity, as well as the subsequent drainage of brine from the ice. The results obtained were found to be in reasonable agreement with field observations in that they showed characteristic C-shaped profiles similar to natural profiles. The average ice salinity values were also in reasonable agreement with field data. The predicted ice property profiles give composite plate properties that are significantly different from bulk property estimates that would result by assuming that sea ice could be represented as a homogeneous plate.

The acceleration sensitivity of quartz crystal oscillators: a review

Abstract: A tutorial on navigation, radar, and identification systems is presented. The topics discussed are the consequences of acceleration sensitivity in crystal oscillators on the Allan variance, including the effects of sinusoidal and random vibration, phase noise and integrated phase jitter; the vector nature of quartz resonator sensitivity; the theoretical description of the cause of the acceleration sensitivity of quartz resonators; techniques for the measurement of acceleration sensitivity; and the effect of frequency multiplication on acceleration effect. Various techniques currently being used or developed for reducing the effective acceleration sensitivity are considered. The techniques fall into three general categories: reduction of the acceleration sensitivity of the resonator; passive techniques that use compensating elements in the oscillator feedback loop, e.g. a second resonator or an acceleration sensitivity capacitor; and active acceleration compensation schemes that sense the acceleration and feedback a compensating signal to a tuning network. >

Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin.

Abstract: Thirty-six monoclonal antibodies to the protective antigen protein of Bacillus anthracis exotoxin have been characterized for affinity, antibody subtype, competitive binding to antigenic regions, and ability to neutralize lethal and edema toxin activities. At least 23 antigenic regions were detected on protective antigen by a blocking, enzyme-linked immunosorbent assay. Two clones, 3B6 and 14B7, competed for a single antigenic region and neutralized the activity of both the lethal toxin in vivo (Fisher 344 rat) and the edema toxin in vitro (CHO cells). These two antibodies blocked the binding of 125I-labeled protective antigen to FRL-103 cells. Our results support the proposal that binding of protective antigen to cell receptors is required for expression of toxicity. Images

Instream flow studies in perspective

Abstract: The Instream Flow Incremental Methodology (IFIM) has been subject to criticisms, including its apparent imprecision, inability to predict discharge-biomass relationships, lack of independence of hydraulic variables, and omission of predation/competition as variables in assessing the dynamics of aquatic populations and communities. This paper addresses criticisms of the methodology, stressing three themes. First, the development of IFIM to its present form is described. The goal of the method is to relate biotic values in equivalent terms to those used to estimate other beneficial uses of water. As such the engineering concepts of hydraulic simulation and suitability criteria play a strong role in the model. Previous studies suggest that IFIM appears to perform defensibly in coldwater systems but less well in more complex coolwater and warmwater systems. Second, the strengths of IFIM are considered and the type of environmental of IFIM are considered and the type of environmental problems it is suited to address are described. Research suggests that biotic responses vary dramatically as certain threshold discharges are approached and it is suggested that biomass predictions are inappropriate with current versions of IFIM. Its greatest utility is shown to be in assessing the impacts of water resources development on habitat availability for aquatic organisms. Third, the limitations of IFIM are presented; those that appear to have merit and those that arise from misapplication or misunderstanding of the methodology. We suggest that suitability criteria be developed on a site specific basis and include depth-velocity dependent functions. The added predictive power by incorporation of coefficients of biological interactions to this management model is probably not justified by the expense required to obtain the data. As a tool, IFIM maximizes generality and precision at the expense of ecological reality but this does not detract from its utility to analyse water resource issues.

Scattering of electromagnetic waves by composite spherical particles: experiment and effective medium approximations

Abstract: We have measured the differential scattering cross sections (phase functions I22) and the normalized extinction and scattering cross sections (efficiences) of composite spherical particles. The size parameter x = 2πr/λ was around 2π. Composite spheres consisted of nonabsorbing matrix containing a small amount (1.6 and 2.7% by volume) of highly absorbing inclusions. Such composite particles may represent a realistic model of fog or cloud droplets containing small amounts of carbon or a composite atmospheric aerosol particle. We have compared measured data with those calculated using seven different effective medium approximations. We have found that the approximations of Bruggeman and Maxwell Garnett, the generalization of dynamic effective medium approximation derived by Chylek and Srivastava, and the experimental waveguide method of determination of the effective refractive index lead to an acceptable agreement between calculated and measured values. The reduced χ2 values for these approximations ranged between 0.6 and 2.0. The remaining three approximations (volume averages of refractive indices or dielectric constants and the Maxwell Garnett relation with matrix and inclusion materials interchanged) lead to reduced χ2 values between 4.0 and 12.0 demonstrating a large disagreement between calculated and measured scattering characteristics.

The Effect of Nicotine on the Attachment of Human Fibroblasts to Glass and Human Root Surfaces in Vitro

Abstract: This study examined the effect of nicotine on fibroblast attachment to glass and nondiseased human root surfaces. Human foreskin fibroblasts (HFF) were trypsinized, suspended in RPMI 1640 medium, and incubated with autoclaved human root sections and nicotine concentrations of zero (control), 25, 50, 100, 200, or 400 ng/ml. The root sections were examined for fibroblast attachment at 24, 48, and 72 hours by light microscopy and scanning electron microscopy (SEM). Additional trypsinized HFF were incubated on glass surfaces with the same concentrations of nicotine and examined at one week by light microscopy. HFF attached and grew on glass and root surfaces at all concentrations of nicotine. Controls on glass surfaces exhibited a normal monolayer of long spindle-shaped fibroblasts with a parallel alignment and minimal overlapping. Nicotine-treated HFF exhibited a haphazard arrangement with cell overlapping and vacuolization of the cytoplasm. Under SEM, the controls had smooth surfaces and appeared firmly attached to the root surface via (1) microvilli and filopodia on the cell boundaries and (2) short, branched, thin-to-medium width cytoplasmic processes with microvilli and filopodia on their boundaries. Few microvilli were noted on the control cell surfaces. HFF exposed to nicotine had microvilli and filopodia on the cell surfaces and long thin and long broad cytoplasmic processes with many microvilli and filopodia that projected away from the root surface. These findings suggest that the nature of fibroblast attachment to glass and root surfaces is altered by nicotine. A similar disturbance in fibroblast attachment may occur in humans who use nicotine-containing products, making them more susceptible to destruction of the periodontium and less responsive to new attachment after periodontal therapy.

Millimeter-wave propagation in vegetation: experiments and theory

Abstract: Microwave/millimeter-wave propagation in woods and forests was investigated at 9.6, 28.8, and 57.6 GHz. The experiments were repeated over the same transmission paths, under both summer and winter conditions, i.e. with tree in leaf and without leaves. Of particular interest were the range dependence, beam broadening, and depolarization of millimeter-wave beams in vegetation and frequency dependence of these effects. The experiments have shown, in particular, that the range dependence is characterized by a high attenuation rate at short vegetation depths and a reduced attenuation rate at large depth. For trees fully in leaf, the transition between the two regimes can be abrupt and the change in attenuation rate substantial. Just after the transition significant beam broadening (and depolarization) occurs. A theory of millimeter-wave propagation in vegetation was derived using transport theory. >

Partial shape recognition using dynamic programming

Abstract: A partial-shape-recognition technique utilizing local features described by Fourier descriptors is introduced. A dynamic programming formulation for shape matching is developed, and a method for comparison of match quality is discussed. This technique is shown to recognize unknown contours that may be occluded or that may overlap other objects. Precise scale information is not required, and the unknown objects may appear at any orientation with respect to the camera. The segment-matching dynamic programming method is contrasted with other sequence-comparison techniques that utilize dynamic programming. Experimental results are discussed that indicate that partial contours can be recognized with reasonable accuracy. >

Microstrip phase scan antenna array

Abstract: A microstrip phase scan antenna array is provided having a columnar array microstrip radiating patches mounted on a dielectric substrate. Each column of the array is fed by a separate variable, reciprocal ferrite rod phase shifter which is mounted on the substrate and is coupled to the column which it controls and to a source of millimeter wave energy by microstrip to dielectric waveguide transitions. Each of the phase shifters is controlled by a helical biasing coil surrounding the ferrite rod. All of the biasing coils are serially interconnected by a single scanning control drive wire and the numbers of turns of the coils are related to each other by an arithmetic progression in which the number of turns of a particular biasing coil differs from the number of turns of the adjacent biasing coil in the sequence of biasing coils controlling the array by a constant amount.

Millimeter-wave propagation at street level in an urban environment

Abstract: Measurements on point-to-point transmission at street level were performed in downtown Denver, CO, with RF probes that operated at 9.6, 28.8, and 57.6 GHz. All probes were mounted on self-contained vehicles, permitting a variety of path scenarios. Information on performance of these channels for propagation in an urban environment on both line-of-sight and non-line-of-sight paths is presented. For non-line-of-sight (non-LOS) paths obstructed by buildings of several common materials, results that showed signal attenuations in excess of 100 dB. When the LOS followed a path directly through clear glass walls, the attenuation was small at all probe frequencies. However, when the glass wall had a metalized coating to reduce ultraviolet and infrared radiation, the attenuation increased by 25 to 50 dB for each metallized layer. In most cases no signals could be detected through steel reinforced concrete or brick buildings. >

Vector potential of selected North American mosquito species for Rift Valley fever virus.

Abstract: Selected North American mosquito species were evaluated as potential vectors of Rift Valley fever virus. Field populations of Aedes canadensis, Ae. cantator, Ae. excrucians, Ae. sollicitans, Ae. taeniorhynchus, Ae. triseriatus, Anopheles bradleyi-crucians, Culex salinarius, Cx. tarsalis, and Cx. territans perorally exposed to 10(6.2)-10(7.2) plaque forming units of Rift Valley fever virus readily became infected. Infection rates ranged from 51% (65/127) for Cx. salinarius to 96% (64/67) for Ae. canadensis. Disseminated infection rates were generally greater at 14 days than at 7 days after the infectious bloodmeal, and, with the exception of An. bradleyi-crucians, they were not significantly different than the pooled rate of 59% for each species tested. Only 5/55 (9%) of the An. bradleyi-crucians developed a disseminated infection. For most of the species, about half of the mosquitoes with a disseminated infection transmitted an infectious dose of virus to hamsters. While all species, with the exception of An. bradleyi-crucians, transmitted virus, Ae. canadensis, Ae. taeniorhynchus, and Cx. tarsalis had the highest vector potential of the species tested. Following inoculation of approximately 10(1.6) plaque forming units of virus, 100% of the mosquitoes of each species became infected. For most species, transmission rates were similar for inoculated individuals and those that developed a disseminated infection following peroral infection. Viral titers of transmitting and nontransmitting-disseminated individuals were similar for all species tested. These data suggest that, if Rift Valley fever virus was introduced into North America, several mosquito species would be capable of transmitting it.

Standard terminology for fundamental frequency and time metrology

Abstract: Measures of frequency and phase instability in the time and frequency domains are reviewed. The particular choice as to which domain is used depends on the application. However, mathematical conversions from one domain to the other can present problems. Most of the major manufacturers now specify instability characteristics of their standard in terms of these recommended measures. This work thus defines and formalizes the general practice of more than a decade. >

Relationship of transfusion and infection in a burn population

Abstract: The relationship between the number of red blood cell transfusions and major infectious complications was evaluated in 594 thermal injury patients admitted between 1982 and 1986 who had burns over 10% or more of total body surface area and survived more than 10 days The mean age of this group was 329 years, with a mean burn size of 36% of total body surface area; 83% were male Of the 594 patients, 237% died and 387% had documented inhalation injury The mean number of red blood cell transfusions received was 197, with a range of 0 to 201 Two hundred fourteen patients (36%) had major infectious complications, defined as pneumonia or invasive burn wound infection A cross-tabulation of predicted mortality, number of transfusions, and infectious complications revealed a significant positive correlation between transfusion number and infectious complications in patients with predicted mortalities between 10 and 70% Per cent total burn, patient age, presence of inhalation injury, and number of transfusions were identified by discriminant function analysis as significant variables (p less than 005) in discriminating between patients with and without infections (85% accuracy) Logistic regression analysis confirmed the above findings, showing a relationship between the number of transfusions received and infectious morbidity which was independent of age or burn size, but no significant relationship between number of transfusions and mortality

The Fox permafrost tunnel: A late Quaternary geologic record in central Alaska

Abstract: The Fox permafrost tunnel, which penetrates 110 m into frozen sediments of Gold-stream valley, provides a continuous exposure of fossiliferous silt and alluvium above schistose bedrock. Deposition of fluvial gravel was followed by a long interval of loess accretion and permafrost aggradation that was punctuated by episodes of thaw and of gullying and redeposition of silt. Imbricated sandy gravel above the bedrock contains lenses of finer alluvium that contain wood fragments and some rooted stumps. Radiocarbon dates indicate that the gravel is older than 40 ka, but absence of mature soil and weathering profiles at its upper contact indicates that fluvial activity must have continued until shortly before loess accretion began at the tunnel site. Silt is the most widespread depositional unit in the tunnel. This deposit is of eolian origin (loess), but some has been redeposited by slope processes. The silt units contain abundant ground ice as pore filings, lenses, wedges, and buried pond ice. Loess accretion was interrupted by a period when little loess accumulated and when large ice wedges formed in the lower loess unit and subsequently were truncated by thaw. Loess began forming sometime before 40 ka and was rapidly accreting by 39 ka under xeric conditions with open vegetation. A sharply decreased rate of loess accretion associated with local erosion and thaw between about 36 and 30 ka is marked by anomalous cation concentration values, lenses of buried sod, fossils indicative of moist to wet substrates, and truncated ice wedges beneath small frozen ponds or streamlets that occupied ice-wedge troughs. A later episode of rapid loess influx under drier conditions began after 30 ka and coincided with glacial advances of late Wisconsin age in the adjoining Alaska Range. Large ice wedges also formed in the upper loess unit, but only their bases are exposed in the tunnel, and their history of development is uncertain. Fanlike deposits of poorly sorted debris near the tunnel portal formed between about 12.5 and 11 ka during deep erosion of loess slopes under moister conditions. The deposits locally form two subunits: the younger over- whelmed a stand of tall willows on the floor of Goldstream valley between about 11.3 and 11.1 ka; the older may have formed about 1,000 yr earlier. Stratigraphic records elsewhere in central Alaska indicate variable middle Wisconsin environments followed by colder and drier conditions that began between 30 and 25 ka and persisted until perhaps 12.5 ka. Widespread loess erosion and redeposition subsequently occurred under moister and probably warmer conditions. Renewed early Holocene loess deposition may have been widespread, but its exact environmental controls are uncertain. Our data challenge three generally accepted concepts of late Quaternary periglacial processes in central Alaska. We contend that (1) many ice-wedge systems may have formed under interstadial conditions rather than full-glacial conditions, (2) episodes of rapid loess influx may have been partly out of phase with episodes of glacier expansion, and (3) redeposition of loess by solifluction, sheetwash, and gully formation may have been episodic and required conditions moister than those under which the loess initially accreted.

System for rapidly tuning a low pressure pulsed laser

Abstract: A rapidly tunable low pressure laser comprised of a one electrode pair lowressure CO2 gas laser gain cell and intra-cavity quarterwave plate and Q-switch. The cell has a fixed laser output coupled at one end of the laser cavity and at the other end of the cavity a wavelength switching device which changes laser lines in less than 1×10-3 μsec, i.e. changes the wavelengths in less than 1 millisecond within the low pressure laser, to produce at least two quick pulses of different wavelengths at a separation of 1 millisecond. The wavelength switching device is comprised of a fast rotating mirror on the laser optical axis and a fixed grating, or a rotating grating on the optical axis.