Institution
Universidade Federal de Rondônia
Education•Porto Velho, Brazil•
About: Universidade Federal de Rondônia is a education organization based out in Porto Velho, Brazil. It is known for research contribution in the topics: Population & Snake venom. The organization has 2232 authors who have published 2614 publications receiving 18062 citations.
Topics: Population, Snake venom, Amazon rainforest, Drainage basin, Venom
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Bat trypanosomes were related by the evolutionary history, ecology and phylogeography of the bats, and clustered with T. dionisii from Europe despite being separated by some genetic distance.
81 citations
••
TL;DR: The results demonstrated that MjTX-II displayed antimicrobial activity by growth inhibition against Escherichia coli and Candida albicans, antitumoral activity against Erlich ascitic tumor (EAT), human breast adenocarcinoma (SK-BR-3) and human T leukemia cells (JURKAT) and antiparasitic effects against Schistosoma mansoni and Leishmania spp.
Abstract: MjTX-II, a myotoxic phospholipase A2 (PLA2) homologue from Bothrops moojeni venom, was functionally and structurally characterized. The MjTX-II characterization included: (i) functional characterization (antitumoral, antimicrobial and antiparasitic effects); (ii) effects of structural modifications by 4-bromophenacyl bromide (BPB), cyanogen bromide (CNBr), acetic anhydride and 2-nitrobenzenesulphonyl fluoride (NBSF); (iii) enzymatic characterization: inhibition by low molecular weight heparin and EDTA; and (iv) molecular characterization: cDNA sequence and molecular structure prediction. The results demonstrated that MjTX-II displayed antimicrobial activity by growth inhibition against Escherichia coli and Candida albicans, antitumoral activity against Erlich ascitic tumor (EAT), human breast adenocarcinoma (SK-BR-3) and human T leukemia cells (JURKAT) and antiparasitic effects against Schistosoma mansoni and Leishmania spp., which makes MjTX-II a promising molecular model for future therapeutic applications, as well as other multifunctional homologous Lys49-PLA2s or even derived peptides. This work provides useful insights into the structural determinants of the action of Lys49-PLA2 homologues and, together with additional strategies, supports the concept of the presence of others “bioactive sites” distinct from the catalytic site in snake venom myotoxic PLA2s.
81 citations
••
University of São Paulo1, Universidade Federal de Santa Maria2, Federal University of Pernambuco3, Universidade Estadual de Maringá4, Universidade Federal de Santa Catarina5, Amazon.com6, University of Brasília7, Empresa Brasileira de Pesquisa Agropecuária8, Universidade Federal de Viçosa9, Federal University of Rio Grande do Norte10, IAC11, Federal Rural University of Amazonia12, Universidade Federal de Mato Grosso13, Universidade Federal Rural do Rio de Janeiro14, University of Florida15, Sao Paulo State University16, Universidade Federal de Sergipe17, Federal Fluminense University18, Federal University of Piauí19, Federal University of Amazonas20, Universidade Federal Rural de Pernambuco21, Universidade Federal de Rondônia22
TL;DR: The Brazilian Soil Spectral Library (BSSL) as mentioned in this paper was developed in a joint partnership with the Brazilian pedometrics community to standardize and evaluate spectra within the 350-2500nm range of Brazilian soils.
78 citations
••
TL;DR: In this article, an effective anionic chromatographic method (HPAEC-PAD) was developed for honey analysis and adulteration detection, which relies on the use of chemometric methods to process chromatograms.
78 citations
••
TL;DR: Results indicate that EE produces dose-related antinociception in several models of chemical and thermal pain through mechanisms that involve an interaction with opioid and serotonergic systems.
Abstract: The present study examined the antinociceptive effects of the ethanolic extract (EE) and of the triterpene 3β,6β,16β-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in chemical and thermal behavioural models of pain in mice. The EE (10–1000 mg/kg) given orally (p.o.), 1 h prior to testing, produced dose-dependent inhibition of acetic acid-induced visceral pain, with mean ID50 value of 131.9 mg/kg. In the formalin test, the EE (10–300 mg/kg, p.o.) also caused significant inhibition of both the early (neurogenic pain) and the late (inflammatory pain) phases of formalin-induced licking, however, it was more potent and efficacious in relation to the late phase of the formalin test, with mean ID50 values for the neurogenic and the inflammatory phases of ∼300 and 88.8 mg/kg, respectively. The EE (10–1000 mg/kg, p.o.) also caused significant and dose-dependent inhibition of capsaicin- and glutamate-induced pain, with mean ID50 values of 160.5 and 38.3 mg/kg, respectively. Furthermore, the triterpene 3β,6β,16β-trihidroxilup-20(29)-ene (1–30 mg/kg), given p.o., 1 h prior to testing, also produced dose-related inhibition of glutamate-induced pain, with a mean ID50 value of 5.6 mg/kg. When assessed in a thermal model of pain, the EE (10–300 mg/kg, p.o.) and fentanyl (100 μg/kg, s.c.) caused a significant and marked increase in the latency response on the hot-plate test (50 °C). The antinociception caused by EE (100 mg/kg, p.o.) in the glutamate test was significantly attenuated by intraperitoneal (i.p.) treatment of mice with naloxone (opioid receptor antagonist, 1 mg/kg), pindolol (a 5-HT1A/1B receptor/β adrenoceptor antagonist, 1 mg/kg), WAY100635 (a 5-HT1A receptor antagonist, 0.7 mg/kg) or ketanserin (a 5-HT2A receptor antagonist, 0.3 mg/kg). In contrast, EE (100 mg/kg, p.o.) antinociception was affected neither by l -arginine (precursor of nitric oxide, 600 mg/kg) nor by ondansetron (a 5-HT3 receptor antagonist, 0.5 mg/kg) i.p. treatment. It was not associated with non-specific effects such as muscle relaxation or sedation. Together, these results indicate that EE produces dose-related antinociception in several models of chemical and thermal pain through mechanisms that involve an interaction with opioid and serotonergic (i.e., through 5-HT1A/1B and 5-HT2A receptors) systems.
77 citations
Authors
Showing all 2255 results
Name | H-index | Papers | Citations |
---|---|---|---|
José G. Dórea | 42 | 226 | 5754 |
Andreimar M. Soares | 38 | 106 | 3423 |
Jean Ricardo Simões Vitule | 32 | 132 | 3266 |
Wanderley Rodrigues Bastos | 31 | 127 | 3007 |
Andreimar M. Soares | 31 | 104 | 3615 |
Pietro Ciancaglini | 30 | 157 | 3206 |
Rodrigo G. Stábeli | 29 | 113 | 2721 |
Gil Guerra-Júnior | 26 | 271 | 3040 |
Mario Alberto Cozzuol | 23 | 56 | 2052 |
Juliana P. Zuliani | 23 | 85 | 1711 |
Rejane C. Marques | 22 | 42 | 1016 |
Fabrice Duponchelle | 22 | 78 | 1465 |
Leonardo A. Calderon | 20 | 69 | 1092 |
Valdir Alves Facundo | 19 | 85 | 1146 |
Braulio Otomar Caron | 18 | 181 | 1359 |