Institution
University of Maryland Biotechnology Institute
About: University of Maryland Biotechnology Institute is a based out in . It is known for research contribution in the topics: Gene & Population. The organization has 1565 authors who have published 2458 publications receiving 171434 citations. The organization is also known as: UMBI.
Topics: Gene, Population, Protein structure, Receptor, Peptide sequence
Papers published on a yearly basis
Papers
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TL;DR: The seasonal pattern of campylobacter infections indicated a linkage with environmental factors rather than food sources, and public health interventions should not be restricted to food-borne approaches, and the epidemiology of the seasonal peak in human campyloblacter infections may best be understood through studies in young children.
Abstract: Campylobacter incidence in England and Wales between 1990 and 1999 was examined in conjunction with weather conditions. Over the 10-year interval, the average annual rate was determined to be 78.4 ± 15.0 cases per 100,000, with an upward trend. Rates were higher in males than in females, regardless of age, and highest in children less than 5 years old. Major regional differences were detected, with the highest rates in Wales and the southwest and the lowest in the southeast. The disease displayed a seasonal pattern, and increased campylobacter rates were found to be correlated with temperature. The most marked seasonal effect was observed for children under the age of 5. The seasonal pattern of campylobacter infections indicated a linkage with environmental factors rather than food sources. Therefore, public health interventions should not be restricted to food-borne approaches, and the epidemiology of the seasonal peak in human campylobacter infections may best be understood through studies in young children.
165 citations
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TL;DR: This study demonstrates the presence and expression of critical virulence genes or their homologues in diverse environmental strains of V. cholerae, which appear to constitute an environmental reservoir of virulent genes, thereby providing new insights into the ecology ofV.
Abstract: The virulence of a pathogen is dependent on a discrete set of genetic determinants and their well-regulated expression. The ctxAB and tcpA genes are known to play a cardinal role in maintaining virulence in Vibrio cholerae, and these genes are believed to be exclusively associated with clinical strains of O1 and O139 serogroups. In this study, we examined the presence of five virulence genes, including ctxAB and tcpA, as well as toxR and toxT, which are involved in the regulation of virulence, in environmental strains of V. cholerae cultured from three different freshwater lakes and ponds in the eastern part of Calcutta, India. PCR analysis revealed the presence of these virulence genes or their homologues among diverse serotypes and ribotypes of environmental V. cholerae strains. Sequencing of a part of the tcpA gene carried by an environmental strain showed 97.7% homology to the tcpA gene of the classical biotype of V. cholerae O1. Strains carrying the tcpA gene expressed the toxin-coregulated pilus (TCP), demonstrated by both autoagglutination analysis and electron microscopy of the TCP pili. Strains carrying ctxAB genes also produced cholera toxin, determined by monosialoganglioside enzyme-linked immunosorbent assay and by passage in the ileal loops of rabbits. Thus, this study demonstrates the presence and expression of critical virulence genes or their homologues in diverse environmental strains of V. cholerae, which appear to constitute an environmental reservoir of virulence genes, thereby providing new insights into the ecology of V. cholerae.
165 citations
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TL;DR: Algorithms for solving the Lamm equations for the reaction-diffusion-sedimentation process in analytical ultracentrifugation are described, and the results are quantitatively consistent with the "constant bath" approximation.
163 citations
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TL;DR: It is concluded that VCP is an integral component of ERAD and cellular stress pathways induced by the unfolded protein response and may be central to the efficacy of CF drugs that target the ubiquitin-proteasome pathway.
162 citations
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TL;DR: The potential of using MBBs to induce different nitrogen transformation processes was evaluated, and it was found that this type of bioreactor has the capability to serve as a platform for mediating desired anoxic processes such as denitrification and anammox.
162 citations
Authors
Showing all 1565 results
Name | H-index | Papers | Citations |
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Stanley B. Prusiner | 168 | 745 | 97528 |
Robert C. Gallo | 145 | 825 | 68212 |
Thomas J. Smith | 140 | 1775 | 113919 |
J. D. Hansen | 122 | 975 | 76198 |
Stephen Mann | 120 | 669 | 55008 |
Donald M. Bers | 118 | 570 | 52757 |
Jon Clardy | 116 | 983 | 56617 |
Rita R. Colwell | 115 | 781 | 55229 |
Joseph R. Lakowicz | 104 | 850 | 76257 |
Patrick M. Schlievert | 90 | 444 | 32037 |
Mitsuhiko Ikura | 89 | 316 | 34132 |
Jeremy Thorner | 87 | 234 | 29999 |
Lawrence E. Samelson | 87 | 209 | 27398 |
Jacques Ravel | 86 | 323 | 45793 |
W. J. Lederer | 79 | 213 | 25509 |