Showing papers by "University of North Carolina at Chapel Hill published in 1984"

Detecting alcoholism. The CAGE questionnaire.

Abstract: Four clinical interview questions, the CAGE questions, have proved useful in helping to make a diagnosis of alcoholism. The questions focus on Cutting down, Annoyance by criticism, Guilty feeling, and Eye-openers. The acronym "CAGE" helps the physician to recall the questions. How these questions were identified and their use in clinical and research studies are described.

Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS

Abstract: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV). Retroviruses belonging to the HTLV family and collectively designated HTLV-III were isolated from a total of 48 subjects including 18 of 21 patients wih pre-AIDS, three of four clinically normal mothers of juveniles with AIDS, 26 of 72 adult and juvenile patients with AIDS, and from one of 22 normal male homosexual subjects. No HTLV-III was detected in or isolated from 115 normal heterosexual subjects. The number of HTLV-III isolates reported here underestimates the true prevalence of the virus since many specimens were received in unsatisfactory condition. Other data show that serum samples from a high proportion of AIDS patients contain antibodies to HTLV-III. That these new isolates are members of the HTLV family but differ from the previous isolates known as HTLV-I and HTLV-II is indicated by their morphological, biological, and immunological characteristics. These results and those reported elsewhere in this issue suggest that HTLV-III may be the primary cause of AIDS.

Measuring Tie Strength

Abstract: Little attention has been given to the measurement of the concept of tie strength. Using survey data on friendship ties, we apply multiple indicator techniques to construct and validate measures of tie strength. We conclude that: (1) there may be two distinct aspects of tie strength, having to do with the time spent in a relationship and the depth of the relationship; (2) a measure of "closeness" or intensity is the best indicator of strength; (3) there are difficulties with frequency and duration of contact as indicators of strength; (4) predictors of strength (e.g., kinship, neighboring) are not especially strongly related to the concept; and (5) the constructed measures of strength, particularly the one of "time spent," are valid in that they are related to predictor variables in anticipated directions. Tie strength is probably the network concept that has attracted the most research attention and the one that has led to the most in the way of substantive contributions. Research using the concept was initiated by the publication of Granovetter's (a) paper entitled "The Strength of Weak Ties," and Granovetter (c) has recently provided an overview of many of the studies that have invoked the concept. Substantive successes have been especially visible in the literature on the process of social mobility, where variations in tie strength have been shown to be systematically related to the outcomes of job search efforts, but there have been applications to other substantive concerns as well. These accomplishments based on the tie strength concept are notable ones. We find, however, an important gap in this literature. Little sustained attention has been given to the measurement of the concept of tie strength, and the (presumably differential) accuracy of the different mea*This paper was presented at the 1983 annual meeting of the American Sociological Association, session on Network Analysis. We thank Lois Verbrugge for help in understanding nuances of the data sources, and Mark Granovetter, Edward 0. Laumann, and Rachel Rosenfeld for helpful comments. Address correspondence to Peter V. Marsden, Department of Sociology, Hamilton Hall 070A, University of North Carolina, Chapel Hill, NC 27514. C) 1984 The University of North Carolina Press

Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action

Abstract: We have validated a method for extracting and measuring the tissue content of somatomedin C (Sm-C)/insulin-like growth factor I (IGF-I), a growth-hormone-dependent, growth-promoting peptide. The Sm-C content of tissue extracts was strongly growth-hormone dependent because most of the tissues studied from hypophysectomized rats contained significantly less Sm-C than normal tissues. The intraperitoneal administration of ovine growth hormone (oGH) to hypophysectomized rats caused tissue extractable Sm-C to increase in kidney, liver, lung, heart, and testes. Tissue Sm-C responses to oGH were maximal after 12 hr, 6 hr before the maximal increment in serum. In liver and lung, the tissue Sm-C response to various doses of oGH fit linear regression models, and the doses of oGH needed to increase the Sm-C are in the range of those required to increase protein synthesis. Although these results do not exclude the possibility that the somatomedins act by hormone-like endocrine mechanisms, they add support to the concept that these peptides act through autocrine or paracrine mechanisms, being produced at multiple sites and acting at or near their sites of production.

Standing out and standing in: The psychology of control in America and Japan.

Abstract: There are at least two general paths to a feeling of control. In primary control, individuals enhance their rewards by influencing existing realities (e.g., other people, circumstances, symptoms, or behavior problems). In secondary control, individuals enhance their rewards by accommodating to existing realities and maximizing satisfaction or goodness of fit with things as they are. American psychologists have written extensively about control, but have generally defined it only in terms of its primary form. This, we argue, reflects a cultural context in which primary control is heavily emphasized and highly valued. In Japan, by contrast, primary control has traditionally been less highly valued and less often anticipated, and secondary control has assumed a more central role in everyday life than in our own culture. To illustrate this cross-cultural difference, we contrast Japanese and American perspectives and practices in child rearing, socialization, religion and philosophy, work, and psychotherapy. These Japanese-American comparisons reveal some key benefits, and some costs, of both primary and secondary approaches to control. In the process, the comparisons reveal the disadvantages of a one-sided pursuit of either form of control. They suggest that an important goal, both for individuals and for cultures, is an optimally adaptive blend of primary and secondary control, a goal best achieved with one's cultural blinders removed. In most American theory and research on the psychology of control, a common theme can be identified; the view that perceived control obtains when individuals shape existing physical, social, or behavioral realities to fit their perceptions, goals, or wishes. According to this view, individuals who do not act to influence such realities may be suffering from learned helplessness (see, e.g., Abramson, Seligman, & Teasdale, 1978), defects in "self-efficacy" (Bandura, 1977), perceptions of self as a "pawn" (deCharms, 1979), or some form of relinquished control (see, e.g., Langer, 1979). Rothbaum, Weisz, and Snyder (1982) recently spelled out a somewhat broader view. They acknowledged that people do often attempt to gain control by influencing existing realities, often via acts involving personal agency, dominance, or even aggression. Rothbaum et al. labeled this process "primary control." But they argued that control is often sought via alternative paths, which they collectively labeled "secondary control." In secondary control, individuals attempt to align themselves with existing realities, leaving them unchanged but exerting control over their personal psychological impact. Table 1 gives an overview of these two forms of control. Rothbaum et al. reviewed evidence indicating that secondary control often involves behaviors that American investigators have typically classified as signs of relinquished control. For example: 1. Attributing outcomes to low ability combined with behaving in a passive and withdrawn manner, is often labeled helplessness; yet, this combination may often represent an attempt to inhibit unfulfillable expectations, thus preparing oneself for future events and thereby gaining predictive secondary control (e.g., Averill, 1973; Lazarus, 1966; Miller & Grant, 1980), Lefcourt (1973) has reviewed several studies suggesting that prediction allows people to prepare themselves for future events and thus to gain control over the psychological impact of those events. 2. When people attribute outcomes to powerful others and show submissive behavior, they are often thought to have abandoned the pursuit of perceived control; yet, this pattern may foster enhanced identification with the powerful others and thus promote vicarious secondary control (e.g., Hetherington & Frankie, 1967; Johnson & Downing, 1979). Fromm (1941) has written about the human inclination to align oneself with powerful entities (e.g., individuals, groups, or institutions) outside the self in order to enhance one's sense of strength or power. 3. The attribution of outcomes to chance, luck, or fate combined with passivity in or withdrawal from certain competitive skill situations is frequently taken as evidence of relinquished control. However, the combination may often reflect an attempt to be September 1984 • American Psychologist Copyright 1984 by the American Psychological Association, Inc. Vol. 39, No. 9, 955-969 955 Table 1 Primary and Secondary Control: An Overview Type of control General strategy Typical targets for causal influence Overall intent

The Incidence of Primary Cardiac Arrest during Vigorous Exercise

Abstract: To examine the risk of primary cardiac arrest during vigorous exercise, we interviewed the wives of 133 men without known prior heart disease who had had primary cardiac arrest. Cases were classified according to their activity at the time of cardiac arrest and the amount of their habitual vigorous activity. From interviews with wives of a random sample of healthy men, we estimated the amount of time members of the community spent in vigorous activity. Among men with low levels of habitual activity, the relative risk of cardiac arrest during exercise compared with that at other times was 56 (95 per cent confidence limits, 23 to 131). The risk during exercise among men at the highest level of habitual activity was also elevated, but only by a factor of 5 (95 per cent confidence limits, 2 to 14). However, among the habitually vigorous men, the overall risk of cardiac arrest--i.e., during and not during vigorous activity--was only 40 per cent that of the sedentary men (95 per cent confidence limits, 0.23 to 0.67). Although the risk of primary cardiac arrest is transiently increased during vigorous exercise, habitual vigorous exercise is associated with an overall decreased risk of primary cardiac arrest.

A consistent empirical potential for water-protein interactions

Abstract: A simple point-charge potential, developed earlier for the calculation of intermolecular forces in molecular-dynamics simulations of liquid water, has been extended to include interactions between water molecules and polar groups of proteins. A complete potential for use in the simulation of protein dynamics in water is reported.

A Role Stress Model of the Performance and Satisfaction of Industrial Salespersons

Abstract: This research proposes an integrative model of the antecedents and consequences of salesforce role stress, with particular emphasis on two outcomes important to sales reps and firms alike: salesfor...

Epstein-Barr virus replication in oropharyngeal epithelial cells.

Abstract: Despite the well-established tropism of the Epstein-Barr virus (EBV) for human B lymphocytes, the cell type within the oropharynx capable of allowing EBV replication has never been conclusively identified. Using in situ cytohybridization, we demonstrated EBV DNA in oropharyngeal epithelial cells from 10 of 12 patients with infectious mononucleosis. In duplicates of specimens found to contain cell-associated EBV DNA, we detected EBV RNA in two of four samples, using a biotin-labeled EBV DNA probe, thereby confirming the intracellular location of the viral genome. In 20 of 28 throat washings analyzed, cytohybridization results and assays for cell-free infectious virus were in agreement. In seven of the eight remaining specimens, cytohybridization identified intracellular EBV DNA in the absence of detectable extracellular virus. We conclude that the oropharyngeal epithelial cell may be the target cell type that is productively infected in infectious mononucleosis.

The Security Dilemma in Alliance Politics

Abstract: The concept of the “security dilemma” is applied to alliance relations in multipolar and bipolar systems. The dilemma involves a choice between support or nonsupport of allies, and tension between fears of entrapment and abandonment. It interacts with the adversary security dilemma in which the choice is between firmness and conciliation toward the opponent. The multipolar interaction is illustrated by a survey of the 1904–1914 period, the bipolar by reference to the contemporary crisis in NATO. The alliance security dilemma is more severe, and places more constraints on allies' policies toward adversaries, in multipolar than in bipolar alliances. The weakness of the dilemma in the contemporary system is a major reason for the current persistence of conflict in NATO.

Space subdivision for fast ray tracing

Abstract: An algorithm is described that speeds up ray-tracing techniques by reducing the number of time-consuming object-ray intersection calculations that have to be made. The algorithm is based on subdividing space into an octree, associating a given voxel with only those objects whose surfaces pass through the volume of the voxel. It includes a technique for obtaining fast access to any node and a mechanism for finding the next node intersected by a ray when it has hit nothing in the current node. This new algorithm makes possible the ray tracing of complex scenes by medium-scale and small-scale computers.

Stage of the Product Life Cycle, Business Strategy, and Business Performance

Abstract: This study empirically examines differences in strategic variables between stages of the product life cycle (PLC), as well as differences among the determinants of high performance across stages of the PLC. The results support the use of the PLC as a contingency variable during strategy formulation. Implications for increasing market share and ROI are discussed.

An Examination of Push-Pull Theory Applied to Process Innovation in Knowledge Work

Abstract: Because many organizations have not been successful in introducing new task and managerial methods into the workplace, considerable attention has been directed toward developing a more complete understanding of organizational innovation. Three separate literatures organizational science, engineering/RD however, surprisingly little integration among the three has occurred. This paper reports on a study which examined a key tenet from each of these literatures in an effort to construct a robust model of innovative behavior. Specifically, the study utilized survey data in examining the validity of "push-pull" theory i.e., that innovation is most likely to occur when a need and a means to resolve that need are simultaneously recognized as well as the importance of top management attitude toward an innovation and of organizational receptivity toward change. The research context involved the diffusion of six modern software practices into 47 software development groups. While the model's independent variables explained a rather large amount of the variance in the use of these modern software practices, "push-pull" theory was not validated. A number of explanations are offered for the apparent failure of "push-pull" theory. Top management attitude and organizational receptivity toward change, however, were generally found to influence organizational innovation. As hypothesized, significant differences emerged in the factors influencing administrative and technical innovations with organizational receptivity toward change important only for the technical innovations. This suggests that organizational processes facilitating innovation should vary depending on the nature of the innovation involved.

Biological communities at the Florida escarpment resemble hydrothermal vent taxa.

Abstract: Dense biological communities of large epifaunal taxa similar to those found along ridge crest vents at the East Pacific Rise were discovered in the abyssal Gulf of Mexico. These assemblages occur on a passive continental margin at the base of the Florida Escarpment, the interface between the relatively impermeable hemipelagic clays of the distal Mississippi Fan and the jointed Cretaceous limestone of the Florida Platform. The fauna apparently is nourished by sulfide rich hypersaline waters seeping out at near ambient temperatures onto the sea floor.

Decrease in Timed Balance Test Scores with Aging

Abstract: This study investigated whether 184 volunteers from 20 to 79 years of age could perform eight timed balance tests and examined the relationship between test performance and age. All subjects were able to balance with their feet together and eyes closed for 30 seconds. The ability to balance on the right and left legs did not differ significantly. Subjects over 60 years of age were unable to balance on one leg, particularly when their eyes were closed, for as long a period as younger subjects. The Pearson product-moment and Spearman correlations of age and duration of one-legged balance were -.65 and -.71 (eyes opened) and -.79 and -.75 (eyes closed). The findings suggest that when timed balance tests are performed as a part of a patient's neurologic examination, the results should be interpreted in light of the patient's age. Information is provided to assist in this interpretation.

The temporal query language TQuel

Abstract: Recently, attention has been focussed on historical databases (HDBs), representing an enterprise over time. We have developed a new language, TQuel, to query an HDB. TQuel is a superset of Quel, the query language in the Ingres relational database management system. This paper provides an overview of the language, motivating the various design decisions with the objective that it be a minimal extension, both syntactically and semantically, of Quel.

An interaction between vinculin and talin.

Abstract: In cultured fibroblasts, microfilament bundles terminate at adhesion plaques (focal contacts), the specialized regions where the cells adhere most tightly to the underlying substrate. Vinculin is a protein concentrated in adhesion plaques and has been suggested as a possible link between the ends of the bundles of actin filaments and the plasma membrane. If vinculin is one protein in a chain of attachment between the bundles of microfilaments and the plasma membrane, it is important to identify other components which interact with vinculin. We have recently discovered a new protein in adhesion plaques which we refer to as talin. Here we show that talin binds to vinculin, which suggests that talin may be involved with vinculin in the attachment of microfilament bundles to the plasma membrane at the adhesion plaques.

Electron density, Kohn−Sham frontier orbitals, and Fukui functions

Abstract: In this note we shall show that the ground-state electron density \(\rho ({\mathbf r})\) is a functional of the highest occupied orbital in Kohn–Sham (Phys Rev 140:A1133, 1965, [1]) theory, \(\psi _{\mathrm {max}}\). The functionals \(\rho [\psi _{\mathrm {max}}]\) for an \((M+\delta )\)-electron system are resolved into three cases and connected to three Fukui functions defined by Parr and Yang (J Am Chem Soc, 106(14):4049, 1984, [2]).

Imitation and social responsiveness in autistic children

Abstract: Fifteen autistic children, ages 4–6 years, participated in the present study. Imitation and object permanence skills were assessed. Language and social behaviors were observed during free play. Children were also exposed to three interactive procedures that differed in developmental sophistication. The experimenter either (1) simultaneously imitated the child's actions, (2) modeled a familiar action, or (3) modeled a novel action. It was found that the autistic children who had a low level of imitative ability (Piaget's Stages 2–3) were more socially responsive, showed more eye contact, and played with toys in a less perseverative manner when the experimenter imitated their behavior than when the experimenter modeled either a familiar or a novel action. When the experimenter modeled a familiar as opposed to a novel action, these children were more likely to spontaneously imitate the experimenter. The autistic children with more highly developed imitation skills, however, responded similarly to all conditions. They also were generally more socially and verbally responsive. These results suggest that developmental status is an important variable in designing intervention programs for severely impaired children.

The Structure and Calcification of the Crustacean Cuticle

Abstract: The integument of decapod crustaceans consists of an outer epicuticle, an exocuticle, an endocuticle and an inner membranous layer underlain by the hypodermis. The outer three layers of the cuticle are calcified. The mineral is in the form of calcite crystals and amorphous calcium carbonate. In the epicuticle, mineral is in the form of spherulitic calcite islands surrounded by the lipid-protein matrix. In the exo- and endocuticles the calcite crystal aggregates are interspersed with chitin-protein fibers which are organized in lamellae. In some species, the organization of the mineral mirrors that of the organic fibers, but such is not the case in certain cuticular regions in the xanthid crabs. Thus, control of crystal organization is a complex phenomenon unrelated to the gross morphology of the matrix. Since the cuticle is periodically molted to allow for growth, this necessitates a bidirectional movement of calcium into the cuticle during postmolt and out during premolt resorption of the cuticle. In two species of crabs studied to date, these movements are accomplished by active transport effected by a Ca-ATPase and Na/Ca exchange mechanism. The epi- and exocuticular layers of the new cuticle are elaborated during premolt but do not calcify until the old cuticle is shed. This phenomenon also occurs in vitro in cuticle devoid of living tissue and implies an alteration of the nucleating sites of the cuticle in the course of the molt.

Physical Properties of Polymers

Abstract: The third edition of this well known textbook discusses the diverse physical states and associated properties of polymeric materials. The contents of the book have been conveniently divided into two general parts, 'Physical States of Polymers' and 'Characterization Techniques'. Written by seven of the leading figures in the polymer science community, this third edition has been thoroughly updated and expanded. As in the second edition, all of the chapters contain general introductory material and comprehensive literature citations designed to give newcomers to the field an appreciation of the subject and how it fits into the general context of polymer science. Containing numerous problem sets and worked examples this third edition provides enough core material for a one semester survey course at the advanced undergraduate or graduate level.

Redox and spectral properties of monooxo polypyridyl complexes of ruthenium and osmium in aqueous media

Abstract: Preparation des complexes [(trpy) (bpy) M-OH 2 ] 2+ (M=Ru, Os). Etude de leurs proprietes redox en solution aqueuse

Behavioral differences between neonatal and adult 6-hydroxydopamine-treated rats to dopamine agonists: relevance to neurological symptoms in clinical syndromes with reduced brain dopamine.

Abstract: Administration of L-dopa or apomorphine to neonatal and adult 6-hydroxydopamine (6-OHDA)-treated rats resulted in different behavioral responses depending on the age at which dopaminergic fibers were destroyed. When neonatal 6-OHDA-treated rats were tested as adults, they exhibited marked stereotypies, self-biting and self-mutilation behavior (SMB) when given these dopamine agonists. Self-biting as well as the incidence of SMB in neonatal 6-OHDA-treated rats showed dose-related changes between 10 and 100 mg/kg of L-dopa. This SMB and self-biting after L-dopa was observed as early as 22 to 24 days of age. Adult 6-OHDA-treated rats did not exhibit SMB or self-biting to L-dopa (100 mg/kg) or apomorphine (10 mg/kg), but did display paw treading and head nodding--behaviors not observed in neonatal 6-OHDA-treated rats. In addition, the locomotor response to apomorphine (1 mg/kg) was significantly greater in adult 6-OHDA-treated rats than in neonatal 6-OHDA-treated rats. Brain dopamine was reduced markedly in striatum, nucleus accumbens and olfactory tubercles in both 6-OHDA treatment groups with the reduction being slightly greater in rats treated with 6-OHDA neonatally. Serotonin content was elevated in striatum of rats treated neonatally with 6-OHDA, but not in adult 6-OHDA-treated rats. SMB and behaviors observed after L-dopa in rats treated neonatally with 6-OHDA were not apparent after L-dopa in rats with brain serotonin or norepinephrine reduced. Rats with brain dopaminergic fibers destroyed neonatally exhibited self-biting and SMB after L-dopa, suggesting that neonatal reduction of this amine is responsible for the SMB and self-biting in neonatal 6-OHDA-treated rats. 5-Hydroxytryptophan administration to neonatal 6-OHDA-treated rats did not induce SMB, indicating that release of serotonin by L-dopa is not responsible for this behavior. Because inhibition of dopamine-beta-hydroxylase did not alter the SMB response to L-dopa observed in neonatal 6-OHDA-treated rats, norepinephrine synthesized from L-dopa does not appear to contribute to the response. High doses of a decarboxylase inhibitor sufficient to inhibit conversion of dopa to dopamine in brain did not reduce the incidence of SMB. Administration of haloperidol (1 mg/kg) reduced the incidence of SMB, but did not antagonize the self-biting or the taffy pulling exhibited by L-dopa. In contrast, cisflupentixol completely blocked the SMB and self-biting induced by L-dopa.(ABSTRACT TRUNCATED AT 400 WORDS)