Institution
Veterans Health Administration
Government•Washington D.C., District of Columbia, United States•
About: Veterans Health Administration is a government organization based out in Washington D.C., District of Columbia, United States. It is known for research contribution in the topics: Population & Veterans Affairs. The organization has 63820 authors who have published 98417 publications receiving 4835425 citations. The organization is also known as: VHA.
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TL;DR: Use of newer therapies for HIV was associated with a large benefit in terms of mortality that was not diminished by any increase in the rate of cardiovascular or cerebrovascular events or related mortality.
Abstract: Background Metabolic abnormalities associated with human immunodeficiency virus (HIV) infection, including dysglycemia and hyperlipidemia, are increasingly prevalent, and there is concern about the possibility of an association with accelerated cardiovascular and cerebrovascular disease. Methods We conducted a retrospective study of the risk of cardiovascular and cerebrovascular disease among the 36,766 patients who received care for HIV infection at Veterans Affairs facilities between January 1993 and June 2001. Results For antiretroviral therapy, 70.2 percent of the patients received nucleoside analogues, 41.6 percent received protease inhibitors, and 25.6 percent received nonnucleoside reverse-transcriptase inhibitors for a median of 17 months, 16 months, and 9 months, respectively. Approximately 1000 patients received combination therapy with a protease inhibitor for at least 48 months, and approximately 1000 patients received combination therapy with a nonnucleoside reverse-transcriptase inhibitor fo...
627 citations
TL;DR: A synthesis of 39 studies found that FDG-PET was more accurate than CT for identifying lymph node involvement and CT was more sensitive but less specific in patients with lymph node enlargement on CT.
Abstract: Positron emission tomography with 18-fluorodeoxyglucose is more accurate than computed tomography for mediastinal staging. However, it is more sensitive but less specific when computed tomography s...
625 citations
University of British Columbia1, University of Calgary2, Harvard University3, Johns Hopkins University4, International Society of Nephrology5, Veterans Health Administration6, Merck & Co.7, University of Groningen8, Concord Repatriation General Hospital9, University of Freiburg10, University of Michigan11, Tufts University12, University of Zurich13, University of California, San Diego14, Panamerican University15, University of Alberta16, University of Sydney17, Karolinska Institutet18, University of Washington19, University College London20, University of Erlangen-Nuremberg21
TL;DR: An action plan and performance framework based on ten themes to strengthen CKD surveillance, tackle major risk factors for CKD, and enhance understanding of the genetic causes of CKD is presented.
624 citations
TL;DR: In patients with SVR, the absolute risk of HCC remained high in patients with established cirrhosis, but among patients treated with DAA, SVR was associated with a considerable reduction in the risk ofHCC.
624 citations
TL;DR: In this paper, a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, and it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor.
Abstract: Substance P is released in the spinal cord in response to painful stimuli, but its role in nociceptive signaling remains unclear. When a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor. This treatment left responses to mild noxious stimuli unchanged, but markedly attenuated responses to highly noxious stimuli and mechanical and thermal hyperalgesia. Thus, lamina I spinal cord neurons that express the substance P receptor play a pivotal role in the transmission of highly noxious stimuli and the maintenance of hyperalgesia.
623 citations
Authors
Showing all 63886 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Michael Karin | 236 | 704 | 226485 |
| Paul M. Ridker | 233 | 1242 | 245097 |
| Eugene Braunwald | 230 | 1711 | 264576 |
| Ralph B. D'Agostino | 226 | 1287 | 229636 |
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Fred H. Gage | 216 | 967 | 185732 |
| Edward Giovannucci | 206 | 1671 | 179875 |
| Rob Knight | 201 | 1061 | 253207 |
| Frank E. Speizer | 193 | 636 | 135891 |
| Stephen V. Faraone | 188 | 1427 | 140298 |
| Scott M. Grundy | 187 | 841 | 231821 |
| Paul G. Richardson | 183 | 1533 | 155912 |
| Peter W.F. Wilson | 181 | 680 | 139852 |
| Dennis S. Charney | 179 | 802 | 122408 |
| Kenneth C. Anderson | 178 | 1138 | 126072 |