Institution
Wake Forest University
Education•Winston-Salem, North Carolina, United States•
About: Wake Forest University is a education organization based out in Winston-Salem, North Carolina, United States. It is known for research contribution in the topics: Population & Diabetes mellitus. The organization has 21499 authors who have published 48731 publications receiving 2246027 citations. The organization is also known as: Wake Forest College.
Topics: Population, Diabetes mellitus, Cancer, Medicine, Blood pressure
Papers published on a yearly basis
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University of Pennsylvania1, Harvard University2, Fox Chase Cancer Center3, University of Texas MD Anderson Cancer Center4, University of California, San Diego5, University of Toronto6, National Foundation for Cancer Research7, University of Illinois at Chicago8, Northwestern University9, Wake Forest University10, Indiana University – Purdue University Indianapolis11, Vanderbilt University12, Mayo Clinic13, University of Chicago14, Johns Hopkins University15, Rutgers University16
TL;DR: Sunitinib and sorafenib, two oral anti-angiogenic agents that are effective in advanced renal-cell carcinoma, are tested in patients with resected local disease at high risk for recurrence in a double-blind, placebo-controlled, randomised, phase 3 trial.
486 citations
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Institute for Health Metrics and Evaluation1, International Centre for Diarrhoeal Disease Research, Bangladesh2, University of Melbourne3, Royal Children's Hospital4, Translational Health Science and Technology Institute5, University of Vermont6, Bill & Melinda Gates Foundation7, World Health Organization8, Centers for Disease Control and Prevention9, University of Virginia10, Uniformed Services University of the Health Sciences11, Wake Forest University12, University of Oxford13
TL;DR: It is suggested that prioritizing vaccine introduction and interventions to reduce diarrhea-associated morbidity and mortality is necessary in the continued global reduction of rotavirus infection.
Abstract: Importance Rotavirus infection is the global leading cause of diarrhea-associated morbidity and mortality among children younger than 5 years. Objectives To examine the extent of rotavirus infection among children younger than 5 years by country and the number of deaths averted because of the rotavirus vaccine. Design, Setting, and Participants This report builds on findings from the Global Burden of Disease Study 2016, a cross-sectional study that measured diarrheal diseases and their etiologic agents. Models were used to estimate burden in data-sparse locations. Exposure Diarrhea due to rotavirus infection. Main Outcomes and Measures Rotavirus-associated mortality and morbidity by country and year and averted deaths attributable to the rotavirus vaccine by country. Results Rotavirus infection was responsible for an estimated 128 500 deaths (95% uncertainty interval [UI], 104 500-155 600) among children younger than 5 years throughout the world in 2016, with 104 733 deaths occurring in sub-Saharan Africa (95% UI, 83 406-128 842). Rotavirus infection was responsible for more than 258 million episodes of diarrhea among children younger than 5 years in 2016 (95% UI, 193 million to 341 million), an incidence of 0.42 cases per child-year (95% UI, 0.30-0.53). Vaccine use is estimated to have averted more than 28 000 deaths (95% UI, 14 600-46 700) among children younger than 5 years, and expanded use of the rotavirus vaccine, particularly in sub-Saharan Africa, could have prevented approximately 20% of all deaths attributable to diarrhea among children younger than 5 years. Conclusions and Relevance Rotavirus-associated mortality has decreased markedly over time in part because of the introduction of the rotavirus vaccine. This study suggests that prioritizing vaccine introduction and interventions to reduce diarrhea-associated morbidity and mortality is necessary in the continued global reduction of rotavirus infection.
485 citations
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Wake Forest University1, Washington University in St. Louis2, Rush University Medical Center3, University of California, Los Angeles4, University of California, San Francisco5, New York University6, Johns Hopkins University7, Stanford University8, Yale University9, National Institutes of Health10, University of Pittsburgh11, University of Vermont12, University of Alabama at Birmingham13
TL;DR: Critical resources are needed to enact this research agenda and include expanded review panel expertise in aging, functional measures, and multimorbidity, and facilitated use and continued funding to allow long-term follow-up of cohorts aging with HIV.
Abstract: HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection, and response to antiretroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy to >70 years of age. Biologic, medical, individual, social, and societal issues change as one ages with HIV infection, but there has been only a small amount of research in this field. Therefore, the Office of AIDS Research of the National Institutes of Health commissioned a working group to develop an outline of the current state of knowledge and areas of critical need for research in HIV and Aging; the working groups' findings and recommendations are summarized in this report. Key overarching themes identified by the group included the following: multimorbidity, polypharmacy, and the need to emphasize maintenance of function; the complexity of assessing HIV versus treatment effects versus aging versus concurrent disease; the inter-related mechanisms of immune senescence, inflammation, and hypercoagulability; the utility of multivariable indices for predicting outcomes; a need to emphasize human studies to account for complexity; and a required focus on issues of community support, caregivers, and systems infrastructure. Critical resources are needed to enact this research agenda and include expanded review panel expertise in aging, functional measures, and multimorbidity, and facilitated use and continued funding to allow long-term follow-up of cohorts aging with HIV.
485 citations
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TL;DR: These functional Cys-SOHs have roles in diverse cellular processes, including signal transduction, oxygen metabolism and the oxidative stress response, and transcriptional regulation, as well as in the industrial production of acrylamide, and their detailed analyses are beginning to provide the chemical foundation necessary for understanding protein-S OH stabilization and function.
Abstract: While it has been known for more than 20 years that unusually stable cysteine-sulfenic acid (Cys-SOH) derivatives can be introduced in selected proteins by mild oxidation, only recently have chemical and crystallographic evidence for functional Cys-SOH been presented with native proteins such as NADH peroxidase and NADH oxidase, nitrile hydratase, and the hORF6 and AhpC peroxiredoxins. In addition, Cys-SOH forms of protein tyrosine phosphatases and glutathione reductase have been suggested to play key roles in the reversible inhibition of these enzymes during tyrosine phosphorylation-dependent signal transduction events and nitrosative stress, respectively. Substantial chemical data have also been presented which implicate Cys-SOH in redox regulation of transcription factors such as Fos and Jun (activator protein-1) and bovine papillomavirus-1 E2 protein. Functionally, the Cys-SOHs in NADH peroxidase, NADH oxidase, and the peroxiredoxins serve as either catalytically essential redox centers or transient intermediates during peroxide reduction. In nitrile hydratase, the active-site Cys-SOH functions in both iron coordination and NO binding but does not play any catalytic redox role. In Fos and Jun and the E2 protein, on the other hand, a key Cys-SH serves as a sensor for intracellular redox status; reversible oxidation to Cys-SOH as proposed inhibits the corresponding DNA binding activity. These functional Cys-SOHs have roles in diverse cellular processes, including signal transduction, oxygen metabolism and the oxidative stress response, and transcriptional regulation, as well as in the industrial production of acrylamide, and their detailed analyses are beginning to provide the chemical foundation necessary for understanding protein-SOH stabilization and function.
483 citations
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TL;DR: In this article, the association of weight status with mortality in adults with new-onset diabetes in order to minimize the influence of diabetes duration and voluntary weight loss on mortality was tested.
Abstract: Context Type 2 diabetes in normal-weight adults (body mass index [BMI] Objective To test the association of weight status with mortality in adults with new-onset diabetes in order to minimize the influence of diabetes duration and voluntary weight loss on mortality. Design, Setting, and Participants Pooled analysis of 5 longitudinal cohort studies: Atherosclerosis Risk in Communities study, 1990-2006; Cardiovascular Health Study, 1992-2008; Coronary Artery Risk Development in Young Adults, 1987-2011; Framingham Offspring Study, 1979-2007; and Multi-Ethnic Study of Atherosclerosis, 2002-2011. A total of 2625 participants with incident diabetes contributed 27 125 person-years of follow-up. Included were men and women (age >40 years) who developed incident diabetes based on fasting glucose 126 mg/dL or greater or newly initiated diabetes medication and who had concurrent measurements of BMI. Participants were classified as normal weight if their BMI was 18.5 to 24.99 or overweight/obese if BMI was 25 or greater. Main Outcome Measures Total, cardiovascular, and noncardiovascular mortality. Results The proportion of adults who were normal weight at the time of incident diabetes ranged from 9% to 21% (overall 12%). During follow-up, 449 participants died: 178 from cardiovascular causes and 253 from noncardiovascular causes (18 were not classified). The rates of total, cardiovascular, and noncardiovascular mortality were higher in normal-weight participants (284.8, 99.8, and 198.1 per 10 000 person-years, respectively) than in overweight/obese participants (152.1, 67.8, and 87.9 per 10 000 person-years, respectively). After adjustment for demographic characteristics and blood pressure, lipid levels, waist circumference, and smoking status, hazard ratios comparing normal-weight participants with overweight/obese participants for total, cardiovascular, and noncardiovascular mortality were 2.08 (95% CI, 1.52-2.85), 1.52 (95% CI, 0.89-2.58), and 2.32 (95% CI, 1.55-3.48), respectively. Conclusion Adults who were normal weight at the time of incident diabetes had higher mortality than adults who are overweight or obese.
482 citations
Authors
Showing all 21721 results
Name | H-index | Papers | Citations |
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Salim Yusuf | 231 | 1439 | 252912 |
Ralph B. D'Agostino | 226 | 1287 | 229636 |
David J. Hunter | 213 | 1836 | 207050 |
Ronald Klein | 194 | 1305 | 149140 |
Luigi Ferrucci | 193 | 1601 | 181199 |
Bruce M. Psaty | 181 | 1205 | 138244 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
Brenda W.J.H. Penninx | 170 | 1139 | 119082 |
Russel J. Reiter | 169 | 1646 | 121010 |
David R. Jacobs | 165 | 1262 | 113892 |
Barbara E.K. Klein | 160 | 856 | 93319 |
Christopher J. O'Donnell | 159 | 869 | 126278 |
Steven R. Cummings | 158 | 579 | 104007 |
David Cella | 156 | 1258 | 106402 |
Jack M. Guralnik | 148 | 453 | 83701 |