Williams College

About: Williams College is a education organization based out in Williamstown, Massachusetts, United States. It is known for research contribution in the topics: Population & Politics. The organization has 2257 authors who have published 5015 publications receiving 213160 citations. The organization is also known as: Williams.

Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis.

Abstract: It remains unclear whether a microRNA (miRNA) affects a given phenotype via concomitant down-regulation of its entire repertoire of targets or instead by suppression of only a modest subset of effectors. We demonstrate that inhibition of breast cancer metastasis by miR-31—a miRNA predicted to modulate >200 mRNAs—can be entirely explained by miR-31's pleiotropic regulation of three targets. Thus, concurrent re-expression of integrin-α5, radixin, and RhoA abrogates miR-31-imposed metastasis suppression. These effectors influence distinct steps of the metastatic process. Our findings have implications concerning the importance of pleiotropy for the biological actions of miRNAs and provide mechanistic insights into metastasis.

Curriculum Guidelines for Undergraduate Programs in Data Science

Abstract: The Park City Math Institute (PCMI) 2016 Summer Undergraduate Faculty Program met for the purpose of composing guidelines for undergraduate programs in Data Science. The group consisted of 25 undergraduate faculty from a variety of institutions in the U.S., primarily from the disciplines of mathematics, statistics and computer science. These guidelines are meant to provide some structure for institutions planning for or revising a major in Data Science.

In the Wrong Place - Alien Marine Crustaceans: Distribution, Biology and Impacts

Abstract: Part I In the Beginning The Global Dispersal of Marine and Estuarine Crustaceans James T. Carlton Part II Global Dispersal Human-Mediated Spread of Alien Crabs Annette Brockerhoff and Colin McLay The Global Spread of the Chinese Mitten Crab Eriocheir sinensis Matt G. Bentley The Japanese Skeleton Shrimp Caprella mutica (Crustacea, Amphipoda): A Global Invader of Coastal Waters Karin Boos, Gail V. Ashton, and Elizabeth J. Cook Part III Alien Faunas by Region Barnacle Invasions: Introduced, Cryptogenic, and Range Expanding Cirripedia of North and South America James T. Carlton, William A. Newman, and Fabio Bettini Pitombo Marine Crustacean Invasions in North America: A Synthesis of Historical Records and Documented Impacts Gregory Ruiz, Paul Fofonoff, Brian Steves, and Alisha Dahlstrom Alien Decapod Crustaceans in the Southwestern Atlantic Ocean Marcos Tavares The Alien and Cryptogenic Marine Crustaceans of South Africa Charles Griffi ths, Tamara Robinson, and Angela Mead The Snow Crab, Chionoecetes Opilio (Decapoda, Majoidae, Oregoniidae) in the Barents Sea Ann-Lisbeth Agnalt, Valery Pavlov, Knut E. Jorstad, E. Farestveit, and Jan Sundet Alien Malacostracan Crustaceans in the Eastern Baltic Sea: Pathways and Consequences Nadezhda A. Berezina, Victor V. Petryashev, Arturas Razinkovas, and Jurate Lesutiene Alien Crustaceans along the Southern and Western Baltic Sea Krzysztof Jazdzewski and Michal Grabowski Checklist of Cryptogenic and Alien Crustacea of the European Atlantic Coast Pierre Y. Noel The Alien Crustaceans in the Mediterranean Sea: An Historical Review Bella S. Galil An Incoming Flood on a Cryptic Stage: Understanding Alien Crustacean Invasions in Southeast Asia Darren C.J. Yeo, James T. Carlton, Serena L.M. Teo, and Peter K.L. Ng Alien Marine Crustaceans of Japan: A Preliminary Assessment Wataru Doi, Seiichi Watanabe, and James T. Carlton Aliens in the Antipodes: Non-indigenous Marine Crustaceans of New Zealand and Australia Shane T. Ahyong and Serena L. Wilkens Part IV Commercial Exploitation of Invasive Decapods The Pacific White Shrimp, Litopenaeus Vannamei, in Asia: The World's Most Widely Cultured Alien Crustacean I Chiu Liao and Yew-Hu Chien The Invasive History, Impact and Management of the Red King Crab Paralithodes camtschaticus off the Coast of Norway Lis Lindal Jorgensen and Einar M. Nilssen The Commercial Exploitation of the Chinese Mitten Crab Eriocheir sinensis in the River Thames, London: Damned if We Don't and Damned if We Do Paul F. Clark Part V Case Studies Live and Let Live: Invasive Host, Charybdis longicollis (Decapoda: Brachyura: Portunidae), and Invasive Parasite, Heterosaccus dollfusi (Cirripedia: Rhizocephala: Sacculinidae) Gianna Innocenti and Bella S. Galil Invasion History and Success of the American Blue Crab Callinectes Sapidus in European and Adjacent Waters Stefan Nehring The Introduced American Lobster, Homarus americanus in Scandinavian Waters Knut E. Jorstad, Ann-Lisbeth Agnalt, and Eva Farestveit Part VI Carcinus in the Wrong Place The Evolutionary Ecology of European Green Crab, Carcinus maenas, in North America Timothy C. Edgell and Johan Hollander More than One Way to Invade: Lessons from Genetic Studies of Carcinus Shore Crabs John A. Darling Ecological Impacts of Replacing One Invasive Species with Another in Rocky Intertidal Areas Blaine D. Griffen Index