Yale University

About: Yale University is a education organization based out in New Haven, Connecticut, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 89824 authors who have published 220665 publications receiving 12834776 citations. The organization is also known as: Yale & Collegiate School.

Longitudinal analyses reveal immunological misfiring in severe COVID-19.

Abstract: Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19)1-4. However, the longitudinal immunological correlates of disease outcome remain unclear. Here we serially analysed immune responses in 113 patients with moderate or severe COVID-19. Immune profiling revealed an overall increase in innate cell lineages, with a concomitant reduction in T cell number. An early elevation in cytokine levels was associated with worse disease outcomes. Following an early increase in cytokines, patients with moderate COVID-19 displayed a progressive reduction in type 1 (antiviral) and type 3 (antifungal) responses. By contrast, patients with severe COVID-19 maintained these elevated responses throughout the course of the disease. Moreover, severe COVID-19 was accompanied by an increase in multiple type 2 (anti-helminths) effectors, including interleukin-5 (IL-5), IL-13, immunoglobulin E and eosinophils. Unsupervised clustering analysis identified four immune signatures, representing growth factors (A), type-2/3 cytokines (B), mixed type-1/2/3 cytokines (C), and chemokines (D) that correlated with three distinct disease trajectories. The immune profiles of patients who recovered from moderate COVID-19 were enriched in tissue reparative growth factor signature A, whereas the profiles of those with who developed severe disease had elevated levels of all four signatures. Thus, we have identified a maladapted immune response profile associated with severe COVID-19 and poor clinical outcome, as well as early immune signatures that correlate with divergent disease trajectories.

Galaxy harassment and the evolution of clusters of galaxies

Abstract: NEARBY clusters of galaxies are filled with red elliptical 'E' and lenticular 'SO' galaxies1, while younger clusters (at redshifts of ≳ 0.4) contain substantial populations of blue spiral galaxies with morphological peculiarities2–7 (see Fig. 1). Thus, within the last 4–5 billion years, galaxies in clusters underwent strong evolution that completely changed their character. By contrast, galaxies that are not associated with clusters show far less morphological evolution8. Here we propose that multiple highspeed encounters between galaxies—'galaxy harassment'— drives the morphological evolution in clusters. Our simulations show that these encounters are very different from mergers; they transform small disk galaxies into dwarf elliptical or dwarf spheroidal galaxies. Harassment will leave detectable debris arcs and could provide fuel for quasars in sub-luminous host galaxies.