Biomechanics and biophysics of cancer cells.
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TLDR
It is reasoned through experimental evidence that greater understanding of the mechanics of cancer cell deformability and its interactions with the extracellular physical, chemical and biological environments offers enormous potential for significant new developments in disease diagnostics, prophylactics, therapeutics and drug efficacy assays.About:
This article is published in Acta Biomaterialia.The article was published on 2007-07-01 and is currently open access. It has received 1243 citations till now. The article focuses on the topics: Neoplastic transformation & Mechanobiology.read more
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Magnetic Nanoparticles in MR Imaging and Drug Delivery
TL;DR: A background on applications of MNPs as MR imaging contrast agents and as carriers for drug delivery and an overview of the recent developments in this area of research are provided.
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Biological materials: Structure and mechanical properties
TL;DR: In this article, the basic building blocks are described, starting with the 20 amino acids and proceeding to polypeptides, polysaccharides, and polyprotein-saccharide.
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Nanomechanical analysis of cells from cancer patients
TL;DR: This work reports the stiffness of live metastatic cancer cells taken from the body fluids of patients with suspected lung, breast and pancreas cancer, and shows that nanomechanical analysis correlates well with immunohistochemical testing currently used for detecting cancer.
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A Tense Situation: Forcing Tumour Progression
TL;DR: The changing force that cells experience needs to be considered when trying to understand the complex nature of tumorigenesis.
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Mechanotransduction gone awry.
Diana E. Jaalouk,Jan Lammerding +1 more
TL;DR: Cells sense their physical surroundings through mechanotransduction — that is, by translating mechanical forces and deformations into biochemical signals such as changes in intracellular calcium concentration or by activating diverse signalling pathways, and these signals can adjust cellular and extracellular structure.
References
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VMD: Visual molecular dynamics
TL;DR: VMD is a molecular graphics program designed for the display and analysis of molecular assemblies, in particular biopolymers such as proteins and nucleic acids, which can simultaneously display any number of structures using a wide variety of rendering styles and coloring methods.
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An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments
Warren C. Oliver,George M. Pharr +1 more
TL;DR: In this paper, the authors used a Berkovich indenter to determine hardness and elastic modulus from indentation load-displacement data, and showed that the curve of the curve is not linear, even in the initial stages of the unloading process.
Book
Intermolecular and surface forces
TL;DR: The forces between atoms and molecules are discussed in detail in this article, including the van der Waals forces between surfaces, and the forces between particles and surfaces, as well as their interactions with other forces.
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Atomic force microscope
TL;DR: The atomic force microscope as mentioned in this paper is a combination of the principles of the scanning tunneling microscope and the stylus profilometer, which was proposed as a method to measure forces as small as 10-18 N. As one application for this concept, they introduce a new type of microscope capable of investigating surfaces of insulators on an atomic scale.
Book
Cellular Solids: Structure and Properties
Lorna J. Gibson,Michael F. Ashby +1 more
TL;DR: The linear elasticity of anisotropic cellular solids is studied in this article. But the authors focus on the design of sandwich panels with foam cores and do not consider the properties of the materials.