Showing papers in "Allergology International in 2020"

TL;DR: This guideline is widely used for various clinical purposes, such as measures for patients with sinusitis, childhood allergic rhinitis, oral allergy syndrome, and anaphylaxis and for pregnant women, for broad clinical applications.

TL;DR: This guideline encourages physicians to follow the principle to let patients consume causative foods in any way and as early as possible.

TL;DR: Inhaled β2-agonists, aminophylline, corticosteroids, adrenaline, oxygen therapy, and other approaches are used as needed during acute exacerbations, by selecting treatment steps for asthma based on the severity of the exacerbations.

TL;DR: The longitudinal safety of anti-IL-5 therapy has been increasingly established, and this strategy will be continuously indicated for eosinophilic diseases as a specific treatment for eOS inophilic inflammation.

TL;DR: Developing purified non-allergenic, highly-immunogenic modified allergen extracts, and combinational usage of them with novel adjuvant molecules via new routes may shorten treatment durations and possibly reduce these drawbacks.

TL;DR: The guidelines present recommendations to review clinical research articles, evaluate the balance between the advantages and disadvantages of medical activities, and optimize medical activity-related patient outcomes with respect to several important points requiring decision-making in clinical practice.

TL;DR: The percentages of severe asthma and SUA patients continuously treated in Japan were obtained through this large-scale analysis using a health insurance claims database, suggesting more appropriate treatment is required according to the treatment guidelines.

TL;DR: It is hoped that dupilumab will open the door to a new era for treating allergic patients with AD, asthma, and CRSwNP, and for more patients with type 2 inflammations.

TL;DR: In the management of severe allergic diseases using omalizumab, issues including cost and concerns about relapse after its discontinuation should be overcome and possibilities for application to other intractable allergic diseases should be considered.

TL;DR: Levels of biomarkers of type 2 inflammation, such as blood/sputum eosinophil counts and fraction of exhaled nitric oxide decreased, however, clinical efficacy was observed irrespective of the baseline levels of these biomarkers.

TL;DR: Air pollution was shown to contribute not only to aggravating the symptoms but also to the increase in the incidence of its severe forms and its mechanistic aspects are discussed in this review in the context of comorbid diseases.

TL;DR: The pivotal functions of IL-24 are revealed for the first time in IL-13-mediated skin barrier dysfunction in atopic dermatitis (AD), which is known to be a characteristic of AD caused by Th2 cytokines such as IL-4 or IL-3.

TL;DR: In this article, a review article summarizes the current knowledge of the clinical features and important aspects of GRP sensitization and allergy, concluding that GRPs are clinically relevant plant allergens.

TL;DR: This review focuses on the discoveries and biological mechanisms of MSCs as a therapeutic tool in allergic diseases and discusses the challenges of conducting MSC studies as well as future directions.

TL;DR: The definition, classification, pathogenesis, test methods, clinical findings, criteria for diagnosis, and therapies of allergic conjunctival disease are summarized based on the Guidelines for Clinical Management of Allergic Conjunctival Disease 2019.

TL;DR: This review highlights recent advances in atopic dermatitis (AD) and food allergy (FA), particularly on molecular mechanisms and disease endotypes, recent developments in global strategies for the management of patients, pipeline for future treatments, primary and secondary prevention and psychosocial aspects.

TL;DR: Recent topics on IL-13 Rα2 in atopic skin inflammation are summarized and it is suggested that scratch-induced IL- 13 R α2 upregulation may attenuate theIL-13-mediated epidermal barrier dysfunction and dermal fibrosis.

TL;DR: Eviologically, there may be a positive association between blood eosinophil counts and BMI in general, but there was a negative correlation in the population with high eos inophils, including the cluster analysis.

TL;DR: The Japanese Guideline for Childhood Asthma (JGCA) 2020 is a translation of the Japanese Pediatric Guideline (JPGL) 2017 into English, which makes recommendations for best practices in the management of childhood asthma, including management of acute exacerbations and non-pharmacological and pharmacological management.

TL;DR: The prevalence of allergic disease among primary school students and middle school students in Japan in 2015 was demonstrated to be higher in male PS and female MS, and each disease exhibited different prevalence ranges and distributions.

TL;DR: The regulation of fatty acid metabolism, especially cys-LT metabolism, in human eosinophils toward allergic inflammatory status is reviewed.

TL;DR: Novel big data containing vast and continuous information on individuals with allergic conjunctivitis and other allergic symptoms are being used to search for causative genes of diseases, gain insights into new biomarkers, prevent disease progression, and, ultimately, improve QoL.

TL;DR: SLOIT showed significant feasibility, efficacy and safety, providing a promising option to manage patients with severe food allergies, with accepted severity-stratified initial and maintenance doses.

TL;DR: Data suggest that increased CD69 expression by eosinophils is not only a biomarker for nasal obstruction and pulmonary dysfunction, but also a potential therapeutic target for patients with ECRS and asthma.

TL;DR: There is an increasing public concern on food allergy and related anaphylactic reactions that occur mainly at the community level and there is the need to establish good evidence -based practices for educational intervention that should be adopted in the context of public health policies for food allergy.

TL;DR: Dual therapy with both SLIT tablets administered within 5 min after 4 weeks of monotherapy with HDM or JCP tablet was well tolerated and induced the expected immunological responses.

TL;DR: For the first time, a deep intronic mutation that was detected by NGS in the SERPING1 gene, was proven pathogenic for C1-INH-HAE and should be performed in cases where standard approaches fail to uncover the genetic alteration.

TL;DR: It was shown that breastfeeding, especially colostrum, had prophylactic effects on food allergy only among high-risk children with infantile eczema whereas prolonged breastfeeding increased the risk of food allergy.

TL;DR: Findings suggest that IFN-α-producing pDCs initiate Alopecia areata by inducing apoptosis and increasing Th1/Tc1 chemokine production such as CXCL10, that accumulates Th1-Tc 1 cells and result in autoimmune reactions against hair follicles.