Showing papers in "Human Immunology in 1989"

TL;DR: The findings suggest that the recruitment of these large granular lymphocytes to the uterus is under hormonal control and is not a local response to the presence of invading trophoblast.

TL;DR: The results demonstrate that non-Asp-57 DQ beta chains are associated with susceptibility to develop IDDM but also indicate that the protection associated with DQ Beta Asp- 57 may not be as dominant as reported by others.

TL;DR: All three chimpanzee DRB genes were found to be more closely related to certain HLA-DRB alleles than unrelated HLA/DRA alleles are to each other, consistent with the idea that closely related ChLA- DRB and Hla-DRBs are derived from common ancestral alleles.

TL;DR: Typing with sequence-specific oligonucleotide probes revealed that the same 59 patients carried DR2-, DR4-, or DRw6-associated HLA-DQB1 genes which encode shared polymorphic amino acid sequences in the membrane-distal part of their Hla-DQ beta chains, which may explain previously reported DR associations.

TL;DR: Observations are consistent with the possibility that immune responsiveness to the allergen Lol p III is associated with this amino acid sequence in the first hypervariable region of the DR beta 1 polypeptide chain.

TL;DR: An Nco I restriction fragment length polymorphism of tumor necrosis factor carried by the 8.1 and 44.1 ancestral haplotypes associated with complications of rheumatoid arthritis is described.

TL;DR: Class II mRNAs were virtually absent in the patients' cell lines (BLS-1 and BLS-2), consistent with previous observations of different BLS patients and their families, and provides further evidence that factors regulating HLA-DQ expression may differ from those governing expression of the other class II genes.

TL;DR: Coordinate regulation of HLA class II gene expression during development and coinduction of class II genes by soluble factors suggests that common trans-acting factor(s) control expression of these genes.

TL;DR: It is demonstrated that the use of oligonucleotide DNA typing permits an analysis of the polymorphism within DRw6 haplotypes and provides a molecular basis for correlations with functional data and can now complement and possibly replace serologic and cellular typing.

TL;DR: Just a short time ago high levels of preformed lymphocytotoxic antibodies in potential renal transplant recipients constituted an almost insurmountable obstacle to finding a suitable donor.

TL;DR: P21, but not p10, was recognized by anti-class II antibody and thus might originate from class II-associated Ii, and p10 might be derived from p21 because its intensity was increased in inverse proportion to p21 as a function of leupeptin or antipain concentration.

TL;DR: The results suggest that aggregation of HLA class I antigens primed cells to become activated in the presence of progression signals including phorbol 12-myristate 13-acetate, recombinant interleukin 2, or anti-CD5 plusAnti-CD28 monoclonal antibodies.

TL;DR: Results presented here suggest that specific DQ beta alleles may modify the effect of HLA-DR4 beta 1 alleles in conferring susceptibility to rheumatoid arthritis in a phenotype-specific fashion.

TL;DR: Several genetic mechanisms including reciprocal recombination, gene conversion, and point mutation were involved in generating the differences between these haplotypes, and the DR3(w18),DQw4 haplotype appears to be relatively stable in the population.

TL;DR: First domain sequences of the B1 locus reveal a cluster of polymorphisms in the third hyperpolymorphic region indicative of gene conversion-like mechanisms in the DRw14 specificity.

TL;DR: Application of the monoclonal antibody-specific immobilization of lymphocyte antigens assay is presented by several examples and identification of DP-specific antibodies as well as serological DP typing are of particular interest.

TL;DR: Serological HLA typing of 92 insulin-dependent diabetes mellitus (IDDM) patients and 300 healthy controls was performed by the immunomagnetic typing technique and found an increased risk of IDDM among DR4/w8 heterozygotes, similar to that seen for DR3/4 heterozygote.

TL;DR: The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined and reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -W13, - w14, and -w8.

TL;DR: Characterization of the gene organization within disease-associated ancestral haplotypes will provide new insights into the functional role and evolution of the major histocompatibility complex.

TL;DR: Using the polymerase chain reaction, data indicate that position 86 of the DR beta 1 chain can play an important role in the formation of determinants recognized by T cells.

TL;DR: The data demonstrate that, unlike man, in dogs there is no unique D locus antigen associated with narcolepsy and suggest that linkage disequilibrium with a specific MHC antigen is unlikely to be essential for the manifestation of canine narcoLEpsy.

TL;DR: Analysis of restriction fragment length polymorphism using HLA class II and T-cell receptor gene probes in an attempt to identify genetic markers more strongly associated with multiple sclerosis than the classically defined antigens DR2, Dw2, and DQw1 raises the possibility that two different DQ alleles, one on each haplotype, may jointly contribute to disease susceptibility.

TL;DR: This analysis represents the first complete assignment of TRG gene rearrangements to given variable and joining gene segments in nonleukemic T cells and provides some evidence for the hypothesis of sequential gamma genes rearrangement during T-lymphocyte differentiation.

TL;DR: The results show that the frequency of the HLA-DP region-derived restriction fragment length polymorphisms linked to celiac disease differs between Caucasian populations of different ethnic backgrounds (Anglo-Saxon and Latin-American).

TL;DR: It is hypothesized that SCID B cells represent a population of B cells present during normal B-cell ontogeny which becomes a minor subset when an individual develops full immunologic competence.

TL;DR: No difference in sequence could be found between narcoleptic and healthy individuals, suggesting thatNarcolepsy is not due to mutation in the DQs gene, and a possible role of the HLA class II antigens in narcoLEpsy is discussed.

TL;DR: The DNA of three previously described C4 deficient patients belonging to unrelated families is studied by restriction fragment length polymorphism analysis using C4 and 21-OH probes and reveals a deletion of the C4B and21-OHA genes in two patients and no deletion at all in the third patient.

TL;DR: The results provide evidence for the expression of the Bra/Brb platelet alloantigen system on VLA-2 antigens of activated T lymphocytes and demonstrate a genetic polymorphism of VLA -2 molecules on both cell lines.

TL;DR: It is suggested that the importance of HLA alleles in insulin-dependent diabetes mellitus susceptibility and the lack of importance of T-cell receptor alpha alleles result from the different strategies by which HLA and T- cell receptor molecules achieve antigen-binding diversity: multiple loci and allelic diversity in the case of Hla; combinatorial, junctional, and N-region diversity inThecell receptor.

TL;DR: None of the eight clinical parameters examined indicate that HLA-DQ mismatches in the presence of compatibility for Hla-DR have any significant effect on either graft function or outcome.