Showing papers in "Journal of Comparative Pathology in 2010"

TL;DR: Lung samples from 148 finishing pigs with cranioventral lobular bronchopneumonia consistent with porcine respiratory disease complex (PRDC) in Denmark revealed a broad range of microscopical lesions and the diversity and number of pathogens were higher in these animals compared with controls.

TL;DR: It will be interesting to test whether similar phenomena occur in relatively long-lived animals, often sharing a human environment, like cats and dogs, and whether interventions to restore appropriate immunity in companion animals might also be applicable to people.

TL;DR: Bats and naked mole-rats in particular have contributed to the abandonment of the rate-of-living theory and weakened enthusiasm for the oxidative stress hypothesis of ageing, and they have shed light on the relationship between specific types of DNA repair and ageing.

TL;DR: The most consistent findings of recent investigations indicate impairment of cell-mediated immune function with age, and the design of optimum nutritional and vaccination programmes for these aged animals must be underpinned by knowledge of the physiological changes that occur in later life.

TL;DR: The recent advances in understanding JSRV and the pathogenesis of OPA should lead to novel strategies for diagnosis and control of this disease and for its exploitation as a comparative model for human lung cancer.

TL;DR: Examining the DOI for core viral vaccines in dogs that had not been revaccinated for as long as 9 years finds that even a single dose of modified live virus (MLV) canine core vaccines or MLV feline core vaccines, when administered at 16 weeks or older, could provide long-term immunity in a very high percentage of animals, while also increasing herd immunity.

TL;DR: It is suggested that PRRSV modulates the immune response by the up-regulation of IL-10, which may in turn reduce expression of cytokines involved in viral clearance (e.g.IFN-α, IFN-γ, IL-12p40 and TNF-α).

TL;DR: The pathological changes present in 300 red tilapias (Oreochromis spp.) naturally infected by Streptococcus agalactiae are described, with the most consistent gross findings were marked congestion of internal organs, particularly the liver, spleen and kidneys.

TL;DR: This paper focuses on age patterns of disease, differences between breeds and genders, body system and disease process and changes over time in Agria Animal Insurance, Sweden.

TL;DR: Four distinct growth patterns of bovine urothelial tumours and tumour-like lesions are recognized: flat, exophytic or papillary, endophytic and invasive.

TL;DR: The severity of brucellosis in S. coeruleoalba indicates that this dolphin species is highly susceptible to infection by B. ceti.

TL;DR: Comparison of the pathogenicity and tissue distribution of the recently emerged QX-like strain of infectious bronchitis virus (IBV) with the widespread M41 and 793/B serotypes of the virus confirmed the ability of all of the tested strains to induce respiratory disease.

TL;DR: Investigation of wild deer for bTB-compatible lesions should include examination of the medial retropharyngeal, left tracheobronchial, mediastinal, mesenteric and ileocaecal lymph nodes, according to findings of this study.

TL;DR: The results of the study suggest that NSAIDs, particularly COX-2 inhibitors, may be useful in the treatment of canine malignant melanoma.

TL;DR: It is suggested that VEGF may contribute to the high angiogenic phenotype of canine IMC and that this expression may underlie the tendency towards local and systemic metastasis of these tumours.

TL;DR: One of the central drivers to this process is age-linked atrophy of the thymus and reversal of this process may have a considerable role in reversing immune decline.

TL;DR: The results of the study confirm the value of histopathological and immunohistochemical techniques for the diagnosis of feline leishmaniosis.

TL;DR: This study describes, for the first time, the commencement, nature and progression of lesions in bovine pneumonic pasteurellosis caused by P. multocida A:3 and provides the foundations for further investigation of the pathogenesis of this disease in cattle.

TL;DR: The metastatic pattern in IMC supports the hypothesis that this form of mammary neoplasia has a distinct pathogenesis and may have value in consideration of the fact that canine IMC has been proposed as a natural model for the study of human inflammatory breast cancer.

TL;DR: Some of the recent findings on immunosenescence in horses are reviewed and the immune response of aged horses to vaccination with a novel recombinant influenza vaccine is discussed.

TL;DR: Investigation of TILs and the presence of related cytokines, as well as the expression of breast cancer susceptibility gene-1 (BRCA1), in canine MGTs suggests all of these factors may play a role in tumour progression.

TL;DR: Early invasion of the intestinal connective tissue was observed; with the presence of single bacteria in the lamina propria 12 hpi, and with a further spread of bacteria inThe lamina Propria observed at 5 dpi, suggesting an active role for the lamination propria in the course of infection.

TL;DR: In normal testes, KIT expression was observed in Leydig cells and in spermatogonia, and it would appear that immunolabelling for KITexpression is a more appropriate means of distinguishing between canine SE and SS.

TL;DR: The most important findings were the presence of pseudocalcium-calcium (pCa-Ca) deposits and arterial wall degeneration and the characterization of age-related lesions in the brains of 60 horses aged from 7 to 23 years.

TL;DR: In this paper, the changes in the naive and memory T cell pool that occur with ageing in man are discussed, along with a brief update of the knowledge of B cell populations in the elderly.

TL;DR: Heifers subjected to oligofructose overload therefore developed generalized sterile neutrophilic polysynovitis and focus on this aspect of bovine laminitis may shed new light on the pathogenesis of this complex disease.

TL;DR: Evidence is provided to suggest that COD in cattle is associated with modifications in the IGF-II system, and a decrease was detected in IGFBP-2 expression in cystic follicles that may be related to the observed higher expression of IGF- II.

TL;DR: A practical method for quantifying the changes that occur in aortic atherosclerosis of rabbits using an image analysis system is reported, which will be useful for the further investigation of Atherosclerosis in rabbits.

TL;DR: Clinical assessment indicated that these lesions had detrimental effects on the vision of the turtles and therefore their potential ability to source food, avoid predators and interact with conspecifics.

TL;DR: It is suggested that VEGF expression occurs in both benign and malignant tumours and is independent of histological type, proliferation, tissue invasion or local metastatic capacity.