Showing papers in "Virus Research in 2018"

TL;DR: Comparison of the genome architectures of RNA viruses discovered by metagenomics and by traditional methods reveals an extent of gene module shuffling among diverse virus genomes that far exceeds the previous appreciation of this evolutionary phenomenon.

TL;DR: This review highlights recent metagenomics studies, which provided a glimpse at the diversity of uncultivated viruses associated with the ubiquitous archaea in the oceans, including Thaumarchaeota, Marine Group II EuryarchAEota, and others, and discusses the origins and evolution of archaeal viruses.

TL;DR: The history of RNA virus metagenomics, reasons for the successes so far, and methodological concerns are explored, and some of the critical accomplishments that have defined the fast pace ofRNA virus discoveries in recent years are highlighted.

TL;DR: It is very unlikely that global eradication and elimination of the cancer risk associated with HCV infection can be achieved without a vaccine, yet research in that direction receives little attention and funding for HCV research must be sustained.

TL;DR: Meta-transcriptomics shows that the RNA virus world is more fluid than previously realized, with relatively frequent changes in genome length and structure, and is suggested that proposals for virus classification pay careful attention to the wonders unearthed in this new age of virus discovery.

TL;DR: Interestingly, ZIKV (and related flaviviruses) has evolved specific mechanisms to overcome autophagy at the ER, thus demonstrating important roles for these autophagic pathways in virus replication and host response.

TL;DR: This review addresses the generation, classification, and regulatory mechanisms of lncRNAs and miRNAs in the interaction between virus and host, focusing on their mutual regulation in viral replication and pathogenesis.

TL;DR: The role of MAPK in virus replication, particularly the role of MNK1 in replication and translation of viral genome is discussed.

TL;DR: Results indicate that PDCoV infection stimulates MOMP either via Bax recruitment or MPTP opening to permit the release of apoptogenic cyt c into the cytoplasm, thereby leading to execution of the caspase-dependent intrinsic apoptosis pathway to facilitate viral replication in vitro.

TL;DR: The latest findings regarding ZIKV-induced adaptive immunity, such as monoclonal and polyclonal antibody responses, structural immunology, and T cell-mediated responses are discussed.

TL;DR: The knowledge of animal Antarctic virology is summaries and potential future directions with the advent of HTS in virus discovery and ecology are discussed.

TL;DR: The efficacy of quinine for stimulating antiviral genes to reduce DENV replication is suggested and may have applicability in the development of new drug therapies against DENV.

TL;DR: Current progress and potential avenues for future developments in this promising era of virus bioinformatics are highlighted and discussed, and some of the major challenges and advantages that bioinformaticians will bring to the field of virology are outlined.

TL;DR: Evidence regarding the association of OS with HR-HPV proteins, and the interplay of the viral proteins with different elements of the antioxidant and DNA damage response (DDR) systems is focused on, emphasizing the processes that might be required for the viral life cycle and viral DNA integration into the host genome.

TL;DR: It is proposed to establish the family Yadokariviridae that accommodates YkV1 and recently discovered viruses phylogenetically related to YnV1, which represents a unique mutualistic virus/virus interplay and similar relations in other virus/host fungus systems are detectable.

TL;DR: The specificity and polysaccharide-degrading activity of the recombinant depolymerases were demonstrated and the phages were classified within the genus Kp32virus and subfamily Autographivirinae, family Podoviridae.

TL;DR: Investigation of ZIKV propagation and quantification in different cell lines found A549 cells appear to be as efficient as the VERO E6 gold standard for plaque assay allowing the use of human, rather than simian, cells for evaluating candidate anti-ZIKV compounds by the reference assay.

TL;DR: The characterization of open reading frame L83L which encodes a highly conserved protein across all ASFV isolates is reported which identifies IL-1β as its host ligand.

TL;DR: According to challenge mortalities and tissue gross/micro lesion results, fiber-2 induced the best protection, followed by fiber-1 and hexon, and the immunoprotective characteristics of these FAdV-4 capsid proteins may prove useful for developing subunit vaccines to control hydropericardium syndrome.

TL;DR: An overview of the interaction of APCs with ASFV is provided, describing the differences between virulent and attenuated strains, and suggesting areas for possible future studies are suggested.

TL;DR: This work considers a yet unsolved molecular mechanism of liver targeting by Ad5-based vectors (CAR-, integrin-, fiber shaft KKTK motif-, and hepatic heparan sulfate glycosaminoglycans-independent, but fiber-, hexon- and blood factor X-dependent).

TL;DR: This is the first report of seed transmissible nature of ToLCNDV, its implication in transboundary movement of the virus across several countries is discussed.

TL;DR: Overall prevalence exceeds 2% whether testing by antibody or HDV RNA and more comprehensive HDV surveillance may be indicated and in a U.S. Midwestern population of HBV infected patients, HDV testing is under-employed.

TL;DR: This is the first report to demonstrate that the p53-dependent pathway plays an important role in PEDV induced cell cycle arrest and beneficially contributes to viral infection.

TL;DR: Through all-in-one lentiviral vector-mediated HIV-1 genome editing, the selected SaCas9/gRNAs can provide an alternative and flexible strategy for anti-HIV gene therapy.

TL;DR: Examination of the effect of virus-induced autophagy on pseudorabies virus (PRV) replication revealed that light chain 3 (LC3)-I was converted into LC3-II after PRV infection; this transition is considered an important indicator of autophagic flux response.

TL;DR: In this paper, the authors developed quantitative methods for the detection of cellular entry and release of SVPs and VLPs by applying a luciferase complementation assay based on the high affinity interaction between the split NanoLuc Luciferase protein, LgBiT and the small peptide, HiBiT.

TL;DR: Evidence is provided that RPL18 is a critical factor required for RSV accumulation in SBPH, which suggests that the vector factor RPL 18 may be as a potential target to develop for controlling the transmission of rice virus.

TL;DR: A review of the transmission of ZIKV in humans, with a focus on both mosquito and sexually-transmitted routes and their outcomes, discusses critical directions for future research.

TL;DR: Investigation of the anti-SVCV activities of 12 plant crude extracts showed that bavachin (BVN), one of the major constituents of Psoralea corylifolia Linn, was also highly effective to SVCV infection, and BVN was considered to develop as a promising agent to treat SVCv infection.