Patent
1,8-naphthyridine derivatives
Isao C,O Daiichi Seiyaku Hayakawa,Masazumi C,O Daiichi Seiyaku Imamura,Naoaki C,O Daiichi Seiyaku Kanaya +5 more
TLDR
In this article, the 1,8-naphthyridine derivatives having antibacterial activity and represented by the following general formula (I): R is a cyclic amino group which may have a substituent; X is a halogen atom, and their pharmacologically acceptable salts and their process for their preparation are disclosedAbstract:
Novel 1,8-naphthyridine derivatives having antibacterial activity and represented by the following general formula (I):
wherein:
R is a cyclic amino group which may have a substituent; and X is a halogen atom, and their pharmacologically acceptable salts and a process for their preparation are disclosedread more
Citations
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Journal ArticleDOI
Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success
TL;DR: The impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains are outlined.
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The fluoroquinolone antibacterials: past, present and future perspectives
Peter C. Appelbaum,P.A. Hunter +1 more
TL;DR: Improved bioavailability is one target achieved with most of the more recent compounds allowing for once-daily dosing, and improvements in pharmacokinetic properties, greater activity against gram-positive cocci and anaerobes, activity against fluoroquinolone-resistant strains, and improved in activity against non-fermentative gram-negative species.
Journal ArticleDOI
Quinolones: from antibiotics to autoinducers
Stephan Heeb,Matthew P. Fletcher,Siri Ram Chhabra,Stephen P. Diggle,Paul Williams,Miguel Cámara +5 more
TL;DR: This work reviews selectively this extensive family of bicyclic compounds, from natural and synthetic antimicrobials to signalling molecules, with a special emphasis on the biology of P. aeruginosa.
Journal ArticleDOI
Evolution and ecology of antibiotic resistance genes
Rustam Aminov,Roderick I. Mackie +1 more
TL;DR: Phylogenetic insights into the evolution and diversity of several antibiotic resistance genes suggest that at least some of these genes have a long evolutionary history of diversification that began well before the 'antibiotic era'.
Journal ArticleDOI
Quinolone generations: natural history or natural selection?
TL;DR: Special attention is given to gemifloxacin, currently the most developmentally advanced third-generation quinolone, which has enhanced in vitro gram-positive antimicrobial activity and no troublesome adverse drug reactions.
References
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Patent
7-substituted-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids; 7-substituted-1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acids; their derivatives; and a process for preparing the compounds
TL;DR: In this paper, the authors describe methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufac- ture of the compounds.
Patent
7-Amino-1-cyclopropyl-4-oxo-1,4-dihydro-(naphthyridine or quinoline)-3-carboxylic acids, process for their preparation and pharmaceutical compositions containing them
TL;DR: In this paper, the general formula for 7-Amino-1-cyclopropyl-4-oxo,1,4-diphydro-naphthyridine-3-carboxylic acids is given.
Patent
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-quinoline-3-carboxylic acids, process for their preparation and antibacterial agents containing them
TL;DR: In this article, the contracting states of the United States of America (US) and the United Kingdom (UK) have made claims for 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino- quinoline-3-carboxylic acid hydroiodide.
Patent
Novel 1,8-Naphthyridine derivatives, and process for preparation thereof
TL;DR: In this article, a 1,8-naphthyridine derivative of the formula R 1, R 2 and R 3 is presented, wherein R 1, R 2, R 3 are the same or different and each hydrogen or lower alkyl having 1 to 5 carbon atoms; esters thereof and salts thereof and processes for preparation thereof.
Patent
1-cyclopropyl-1, 4-dihydro-6-fluoro-4-oxo-1, 8-naphthyridine-3-carboxylic acids; their derivatives and a process for preparing the compounds
TL;DR: A process for producing the compounds and pharmaceutical compositions comprising the compounds are also described in this paper, where the compounds were useful as antibacterial agents, and the compounds of formula X are disclosed.