2019 novel coronavirus infection and gastrointestinal tract
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TLDR
It is speculated that COVID-19 may have some relationship with the gut microbiota through angiotensin-converting enzyme 2 (ACE2) receptor, thus targeting gut microbiota might be a new therapeutic option for the treatment of virus-related pneumonia.Citations
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Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study.
Lei Pan,Lei Pan,Mi Mu,Pengcheng Yang,Yu Sun,Runsheng Wang,Junhong Yan,Pibao Li,Baoguang Hu,Jing Wang,Chao Hu,Yuan Jin,Xun Niu,Rongyu Ping,Yingzhen Du,Tianzhi Li,Guogang Xu,Qinyong Hu,Lei Tu +18 more
TL;DR: It is found that digestive symptoms are common in patients with COVID-19 and that the index of suspicion may need to be raised earlier in at-risk patients presenting with digestive symptoms, but further large sample studies are needed to confirm these findings.
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First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: A proof of concept for the wastewater surveillance of COVID-19 in the community.
Warish Ahmed,Nicola Angel,Janette Edson,Kyle Bibby,Aaron Bivins,Jake W. O'Brien,Phil M. Choi,Masaaki Kitajima,Stuart L. Simpson,Jiaying Li,Benjamin J. Tscharke,Rory Verhagen,Wendy Smith,Julian Zaugg,Leanne Dierens,Philip Hugenholtz,Kevin V. Thomas,Jochen F. Mueller +17 more
TL;DR: The quantification of SARS-CoV-2 in wastewater affords the ability to monitor the prevalence of infections among the population via wastewater-based epidemiology (WBE) and highlights the viability of WBE for monitoring infectious diseases, such as COVID-19, in communities.
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SARS-CoV-2 in wastewater: State of the knowledge and research needs.
Masaaki Kitajima,Warish Ahmed,Kyle Bibby,Annalaura Carducci,Charles P. Gerba,Kerry A. Hamilton,Eiji Haramoto,Joan B. Rose +7 more
TL;DR: There is an urgent need for further research to establish methodologies for wastewater surveillance and understand the implications of the presence of SARS-CoV-2 in wastewater.
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Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management.
Ferdinando D'Amico,Ferdinando D'Amico,Daniel C. Baumgart,Silvio Danese,Laurent Peyrin-Biroulet +4 more
TL;DR: Investigating the epidemiology, clinical presentation, molecular mechanisms, management, and prevention of SARS-CoV-2 associated diarrhea indicates possible fecal oral transmission, indicating the need for a rapid and effective modification of the screening and diagnostic algorithms.
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Computational analysis of SARS-CoV-2/COVID-19 surveillance by wastewater-based epidemiology locally and globally: Feasibility, economy, opportunities and challenges.
Olga E. Hart,Rolf U. Halden +1 more
TL;DR: Data provided here demonstrate this approach to save money, be broadly applicable worldwide, and potentially aid in precision management of the pandemic, thereby helping to accelerate the global economic recovery that billions of people rely upon for their livelihoods.
References
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Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
Journal ArticleDOI
A new coronavirus associated with human respiratory disease in China.
Fan Wu,Su Zhao,Bin Yu,Yan-Mei Chen,Wen Wang,Zhi gang Song,Yi Hu,Zhao Wu Tao,Jun Hua Tian,Yuan Yuan Pei,Ming Li Yuan,Yu Ling Zhang,Fa Hui Dai,Yi Liu,Qi Min Wang,Jiao Jiao Zheng,Lin Xu,Edward C. Holmes,Edward C. Holmes,Yong-Zhen Zhang,Yong-Zhen Zhang +20 more
TL;DR: Phylogenetic and metagenomic analyses of the complete viral genome of a new coronavirus from the family Coronaviridae reveal that the virus is closely related to a group of SARS-like coronaviruses found in bats in China.
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Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
Wei Zhang,Rong-Hui Du,Bei Li,Xiao-Shuang Zheng,Xing-Lou Yang,Ben Hu,Yan-Yi Wang,Gengfu Xiao,Bing Yan,Zhengli Shi,Peng Zhou +10 more
TL;DR: Investigation on patients in a local hospital who were infected with a novel coronavirus found the presence of 2019-nCoV in anal swabs and blood, and more anal swab positives than oral swabs positives in a later stage of infection, suggesting shedding and thereby transmitted through oral–fecal route.
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