3D Bioprinting: from Benches to Translational Applications.
Marcel A. Heinrich,Marcel A. Heinrich,Wanjun Liu,Wanjun Liu,Andrea Jimenez,Jingzhou Yang,Ali Akpek,Ali Akpek,Ali Akpek,Xiao Liu,Xiao Liu,Qingmeng Pi,Qingmeng Pi,Xuan Mu,Ning Hu,Ning Hu,Raymond M. Schiffelers,Jai Prakash,Jingwei Xie,Yu Shrike Zhang +19 more
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TLDR
The history of bioprinting and the most recent advances in instrumentation and methods are covered, and the requirements for bioinks and cells to achieve optimal fabrication of biomimetic constructs are focused on.Abstract:
Over the last decades, the fabrication of 3D tissues has become commonplace in tissue engineering and regenerative medicine. However, conventional 3D biofabrication techniques such as scaffolding, microengineering, and fiber and cell sheet engineering are limited in their capacity to fabricate complex tissue constructs with the required precision and controllability that is needed to replicate biologically relevant tissues. To this end, 3D bioprinting offers great versatility to fabricate biomimetic, volumetric tissues that are structurally and functionally relevant. It enables precise control of the composition, spatial distribution, and architecture of resulting constructs facilitating the recapitulation of the delicate shapes and structures of targeted organs and tissues. This Review systematically covers the history of bioprinting and the most recent advances in instrumentation and methods. It then focuses on the requirements for bioinks and cells to achieve optimal fabrication of biomimetic constructs. Next, emerging evolutions and future directions of bioprinting are discussed, such as freeform, high-resolution, multimaterial, and 4D bioprinting. Finally, the translational potential of bioprinting and bioprinted tissues of various categories are presented and the Review is concluded by exemplifying commercially available bioprinting platforms.read more
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Direct writing by way of melt electrospinning
TL;DR: In this paper, a melt electrospun fibers of poly(ϵ-caprolactone) are accurately deposited using an automated stage as the collector, which matches the translation speed of the collector to the speed of a melting jet to establish control over the location of fiber deposition.
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Development of 3D bioprinting: From printing methods to biomedical applications.
TL;DR: This work systematically review the evolution, process and classification of 3D bioprinting with an emphasis on the fundamental printing principles and commercialized bioprinters.
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Current applications of poly(lactic acid) composites in tissue engineering and drug delivery
TL;DR: Recent progress on strategies to address PLA problems is summarized, including novel fabrication techniques, high-performance PLA composites, and their applications for tissue engineering and drug delivery.
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3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions
João Rodrigues,João Rodrigues,Marcel A. Heinrich,Liliana Moreira Teixeira,Liliana Moreira Teixeira,Jai Prakash +5 more
TL;DR: An overview of state-of-the-art 3D models for studying tumor-stroma interactions, with a focus on understanding why the TME is a key target in cancer therapy.
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Wound Healing: From Passive to Smart Dressings.
Mojtaba Farahani,Abbas Shafiee +1 more
TL;DR: In this paper, the importance of smart wound dressings as an emerging strategy for wound care management and highlights different types of smart dressings for promoting the wound healing process is discussed.
References
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A review on polymer nanofibers by electrospinning and their applications in nanocomposites
TL;DR: In this article, a comprehensive review is presented on the researches and developments related to electrospun polymer nanofibers including processing, structure and property characterization, applications, and modeling and simulations.
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Electrospinning of Nanofibers: Reinventing the Wheel?†
Dan Li,Younan Xia +1 more
TL;DR: An overview of electrospinning can be found in this article, where the authors focus on progress achieved in the last three years and highlight some potential applications associated with the remarkable features of electro-spun nanofibers.