A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins
Andrew D. Ferguson,Andrew D. Ferguson,Wolfram Welte,Eckhard Hofmann,Buko Lindner,Otto Holst,James W. Coulton,Kay Diederichs +7 more
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TLDR
These four residues, three of which form specific interactions with lipid A, appear to provide the structural basis of pattern recognition in the innate immune response and could serve as a template for molecular modeling of a LPS scavenger designed to reduce the septic shock syndrome.About:
This article is published in Structure.The article was published on 2000-06-01 and is currently open access. It has received 195 citations till now. The article focuses on the topics: Bacterial outer membrane & Lipid A.read more
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Molecular Basis of Bacterial Outer Membrane Permeability Revisited
TL;DR: This review summarizes the development in the field since the previous review and begins to understand how this bilayer of the outer membrane can retard the entry of lipophilic compounds, owing to increasing knowledge about the chemistry of lipopolysaccharide from diverse organisms and the way in which lipopoly Saccharide structure is modified by environmental conditions.
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Inflammatory caspases are innate immune receptors for intracellular LPS
TL;DR: It is shown that human monocytes, epithelial cells and keratinocytes undergo necrosis upon cytoplasmic delivery of LPS, which represents a new mode of pattern recognition in immunity and also an unprecedented means of caspase activation.
Journal ArticleDOI
Lipid a modification systems in gram-negative bacteria
TL;DR: Diverse covalent modifications of the lipid A moiety may occur during its transit from the outer surface of the inner membrane to the outer membrane of most gram-negative bacteria.
Journal ArticleDOI
Bacterial lipopolysaccharides and innate immunity
TL;DR: The elucidation of structure-activity correlations in LPS and lipid A has not only contributed to a molecular understanding of both immunostimulatory and toxic septic processes, but has also re-animated the development of new pharmacological and immunostIMulatory strategies for the prevention and therapy of infectious and malignant diseases.
Journal ArticleDOI
Lipid–protein interactions in biological membranes: a structural perspective
TL;DR: Lipid molecules bound to membrane proteins are resolved in some high-resolution structures of membrane proteins, and an analysis of these structures provides a framework within which to analyse the nature of lipid-protein interactions within membranes.
References
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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
Journal ArticleDOI
MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
Journal ArticleDOI
Improved methods for building protein models in electron density maps and the location of errors in these models.
TL;DR: In this paper, the authors describe strategies and tools that help to alleviate this problem and simplify the model-building process, quantify the goodness of fit of the model on a per-residue basis and locate possible errors in peptide and side-chain conformations.
Book
Escherichia coli and Salmonella :cellular and molecular biology
TL;DR: The Enteric Bacterial Cell and the Age of Bacteria Variations on a Theme by Escherichia is described.
Book ChapterDOI
Raster3D: photorealistic molecular graphics.
Ethan A. Merritt,David Bacon +1 more
TL;DR: Raster3D is discussed, which is a suite of programs for molecular graphics, which must compromise the quality of rendered images to achieve rendering speeds high enough for useful interactive manipulation of three-dimensional objects.