Journal ArticleDOI
A krill oil supplemented diet reduces the activities of the mitochondrial tricarboxylate carrier and of the cytosolic lipogenic enzymes in rats.
TLDR
In rats fed with a diet enriched with 2.5% krill oil, a time-dependent decrease in the activities of the mitochondrial tricarboxylate carrier and of the lipogenic enzymes was found and a greater reduction in the levels of hepatic triglycerides and cholesterol was found in comparison to FO-fed rats.Abstract:
The mitochondrial tricarboxylate carrier supplies cytosol with the carbon units necessary for hepatic lipogenesis. The activities of cytosolic acetyl-CoA carboxylase and fatty acid synthetase are therefore strictly connected to the function of mitochondrial tricarboxylate carrier. Dietary polyunsaturated fatty acids (PUFA) are potent modulators of hepatic lipogenesis. In rats fed with a diet enriched with 2.5% krill oil (KO), a novel source of dietary n-3 PUFA, a time-dependent decrease in the activities of the mitochondrial tricarboxylate carrier and of the lipogenic enzymes was found. The KO induced inhibition of hepatic lipogenesis was more pronounced than that found in fish oil (FO)-fed rats, at least at short feeding times. The decrease in the activity of the mitochondrial tricarboxylate carrier caused by KO was due to a reduced expression of the protein. Furthermore, in the KO-fed animals a greater reduction in the levels of hepatic triglycerides and cholesterol was found in comparison to FO-fed rats.read more
Citations
More filters
Journal ArticleDOI
Marine Omega-3 Phospholipids: Metabolism and Biological Activities
TL;DR: The recently discovered nutritional properties of n-3 PLs on different parameters of metabolic syndrome are described and their different metabolic bioavailability in comparison to other dietary forms ofn-3 FAs are highlighted.
Journal ArticleDOI
Modulation of hepatic steatosis by dietary fatty acids.
TL;DR: Major data from the literature about the role of some dietary fats as a potential cause of hepatic fat accumulation or as a possible treatment for NAFLD are described and biochemical mechanisms responsible for an increase or decrease in hepatic lipid content are critically analyzed.
Journal ArticleDOI
Antioxidant dietary approach in treatment of fatty liver: New insights and updates.
TL;DR: This review focuses on the role of dysfunctions in mitochondrial bioenergetics in the pathogenesis of fatty liver and major data from the literature about the mitochondrial targeting of some antioxidant molecules as a potential treatment for hepatic steatosis are described and critically analysed.
Journal ArticleDOI
Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α.
Natalya Filipchuk Vigerust,Bodil Bjørndal,Pavol Bohov,Trond Brattelid,Asbjørn Svardal,Rolf K. Berge,Rolf K. Berge +6 more
TL;DR: KO, containing bioactive n-3 PUFAs in the form of phospholipids, was capable of modulating lipid metabolism by lowering plasma levels of TAG and cholesterol and stimulating the mitochondrial and peroxisomal fatty acid β-oxidation, as well as improving the overall carnitine turnover.
Journal ArticleDOI
A Krill Oil Supplemented Diet Suppresses Hepatic Steatosis in High-Fat Fed Rats
Alessandra Ferramosca,Annalea Conte,Lena Burri,Kjetil Berge,Francesco De Nuccio,Anna Maria Giudetti,Vincenzo Zara +6 more
TL;DR: The investigation of the molecular mechanisms of KO action in high-fat fed animals revealed a strong decrease in the activities of the mitochondrial citrate carrier and of the cytosolic acetyl-CoA carboxylase and fatty acid synthetase, which are both involved in hepatic de novo lipogenesis.
References
More filters
Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
A rapid method of total lipid extraction and purification.
E. G. Bligh,W. J. Dyer +1 more
TL;DR: The lipid decomposition studies in frozen fish have led to the development of a simple and rapid method for the extraction and purification of lipids from biological materials that has been applied to fish muscle and may easily be adapted to use with other tissues.
Journal ArticleDOI
The opposing effects of n-3 and n-6 fatty acids
Gerd Schmitz,Josef Ecker +1 more
TL;DR: In this article, the authors classified polyunsaturated fatty acids (PUFAs) in n-3 fatty acids and n-6 fatty acids, and in westernized diet the predominant dietary PUFAs are n- 6 fatty acids.
Journal ArticleDOI
Polyunsaturated fatty acids in the food chain in the United States
Penny M. Kris-Etherton,Denise Shaffer Taylor,Shaomei Yu-Poth,Peter Huth,Kristin Moriarty,Valerie Fishell,Rebecca L Hargrove,Guixiang Zhao,Terry D. Etherton +8 more
TL;DR: Alternative strategies, such as food enrichment and the use of biotechnology to manipulate the EPA and DHA as well as ALA contents of the food supply, will become increasingly important in increasing n-3 fatty acid intake in the US population.