Journal ArticleDOI
The opposing effects of n-3 and n-6 fatty acids
Gerd Schmitz,Josef Ecker +1 more
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TLDR
In this article, the authors classified polyunsaturated fatty acids (PUFAs) in n-3 fatty acids and n-6 fatty acids, and in westernized diet the predominant dietary PUFAs are n- 6 fatty acids.About:
This article is published in Progress in Lipid Research.The article was published on 2008-03-01. It has received 1087 citations till now. The article focuses on the topics: Polyunsaturated fatty acid & Fatty acid.read more
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Fatty acid requirements in ontogeny of marine and freshwater fish
TL;DR: It is particularly important to note that the physiological requirements of the fish to prevent deficiency pathologies and produce optimal growth may not parallel the requirements for maintaining nutritional quality, so salmonids can be successfully cultured on vegetable oils devoid of long-chain n-3 PUFA but not without potentially compromising their health benefits to the human consumer.
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Understanding the mechanisms and treatment options in cancer cachexia
TL;DR: The combination of therapies into a standard multimodal package coupled with the development of novel therapeutics promises a new era in supportive oncology whereby quality of life and tolerance to cancer therapy could be improved considerably.
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Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention.
TL;DR: This review highlights the important cardioprotective effect of n-3 in the secondary prevention of sudden cardiac death due to arrhythmias, but suggests caution to recommend dietary supplementation of PUFAs to the general population, without considering, at the individual level, the intake of total energy and fats.
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Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids
TL;DR: Increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease, cardiovascular disease, obesity, inflammatory bowel disease, rheumatoid arthritis, and Alzheimer's disease are increases, so reducing the ratio of (n-3) : (n-6) PUFA in the Western diet may be achieved in the incidence of these chronicinflammatory diseases.
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Omega-3 and omega-6 polyunsaturated fatty acids: Dietary sources, metabolism, and significance - A review.
TL;DR: Major sources, intake, and global consumption of n-3 and n-6 PUFAs are summarized and their metabolism to biosynthesize long-chain PUF as and eicosanoids and their roles in brain metabolism, cardiovascular disease, obesity, cancer, and bone health are discussed.
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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
TL;DR: The complex, interdigitated roles of these three SREBPs have been dissected through the study of ten different lines of gene-manipulated mice and form the subject of this review.
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Missing Pieces in the NF-κB Puzzle
Sankar Ghosh,Michael Karin +1 more
TL;DR: In this paper, a review of recent progress as well as unanswered questions regarding the regulation and function of NF-kappaB and IKK is presented, focusing on recent progress and unanswered questions.
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A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Steven A. Kliewer,James M. Lenhard,Timothy M. Willson,Inder Patel,David C. Morris,Jürgen M. Lehmann +5 more
TL;DR: The PGJ2 and its derivatives are efficacious activators of peroxisome proliferator-activated receptors alpha and gamma (PPAR alpha and PPAR gamma, respectively), orphan nuclear receptors implicated in lipid homeostasis and adipocyte differentiation and suggest a novel mechanism of action for PGs of the J2 series.
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Nuclear receptors and lipid physiology: opening the X-files.
TL;DR: Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.
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The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells
Stefan Endres,Reza Ghorbani,V E Kelley,Kostis Georgilis,Gerhard Lonnemann,J.W.M. van der Meer,Joseph G. Cannon,T S Rogers,Mark S. Klempner,Peter C. Weber +9 more
TL;DR: It is concluded that the synthesis ofIL-1 beta, IL-1 alpha, and tumor necrosis factor can be suppressed by dietary supplementation with long-chain n-3 fatty acids.