Journal ArticleDOI
A Longitudinal Study of Apolipoprotein-E Genotype and Depressive Symptoms in Community-Dwelling Older Adults
Maritess Mauricio,Ruth O'Hara,Jerome A. Yesavage,Leah Friedman,Helena C. Kraemer,Margaret Van De Water,Greer M. Murphy +6 more
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TLDR
Results do not support the hypothesis that the APOE epsilon 4 allele is associated with depression, and the specificity of APOE genotyping in AD diagnosis would not appear to be compromised by an association with depression.Abstract:
The Apolipoprotein-E (APOE) ɛ4 allele is a risk factor for Alzheimer's disease (AD) and cognitive decline in older adults. Depression may also be a risk factor for dementia, and depression is important in the differential diagnosis of dementia. The authors performed a 5-year longitudinal study of APOE genotype and change in Geriatric Depression Scale scores in 113 community-dwelling older adults. No association was observed between APOE genotype and change in depressive symptoms. These results do not support the hypothesis that the APOE ɛ4 allele is associated with depression. Important objections have been raised to APOE genotyping in the diagnosis of AD. However, the specificity of APOE genotyping in AD diagnosis would not appear to be compromised by an association with depression.read more
Citations
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Journal ArticleDOI
Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele
Richard J. Caselli,Eric M. Reiman,David Osborne,J. G. Hentz,Leslie C. Baxter,Jose L. Hernandez,G. G. Alexander +6 more
TL;DR: Memory declined in APOE e4 carriers before the symptomatic presentation of MCI in a cohort whose mean age was 60 years over a median period of 33 months, and began prior to age 60.
Journal ArticleDOI
Regional cerebral metabolism in early Alzheimer’s disease with clinically significant apathy or depression
Vjera Holthoff,Bettina Beuthien-Baumann,Elke Kalbe,Susanne Lüdecke,Olaf Lenz,Gerhard Zündorf,Sebastian Spirling,Kristin Schierz,Peter Winiecki,Sandro Sorbi,Karl Herholz +10 more
TL;DR: The notion that different functional circuits underlie apathy and depression in early AD is supported, with significant decreases in left orbitofrontal regions when compared with patients free of apathy.
Journal ArticleDOI
Clinically Significant Non-Major Depression: Old Concepts, New Insights
Helen Lavretsky,Anand Kumar +1 more
TL;DR: The authors discuss the literature pertaining to the current concepts, phenomenology, neurobiology, and treatment approaches to geriatric non-major clinically significant depression, examines the similarities and differences between various subtypes of depressive disorders and proposes clinical criteria for the diagnosis of clinically significant non- major depression in elderly persons.
Journal ArticleDOI
Distinguishing between depression and dementia in older persons: neuropsychological and neuropathological correlates.
Sara L. Wright,Carol Persad +1 more
TL;DR: Suggestions for clinicians when deciding who to refer for neuropsychological assessment are suggested and ideas for further research are suggested that might promote a better understanding of the complex association between depression and dementia during old age.
Journal ArticleDOI
Geriatric depression and vascular diseases: what are the links?
TL;DR: Clinical and epidemiological evidence linking geriatric depression and vascular diseases is reviewed, and the potential mechanisms that could underlie this association are discussed.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Development and validation of a geriatric depression screening scale: A preliminary report
Jerome A. Yesavage,T. L. Brink,Terence L. Rose,Owen Lum,Virginia Huang,Michael Adey,Von O. Leirer +6 more
TL;DR: A new Geriatric Depression Scale (GDS) designed specifically for rating depression in the elderly was tested for reliability and validity and compared with the Hamilton Rating Scale for Depression (HRS-D) and the Zung Self-Rating Depression Scale(SDS) as discussed by the authors.
Journal ArticleDOI
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The APOE-epsilon 4 allele is associated with the common late onset familial and sporadic forms of Alzheimer9s disease (AD) in 42 families with late onset AD.
Journal ArticleDOI
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
James E. Hixson,D. T. Vernier +1 more
TL;DR: This work has used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing of common apolipoprotein E isoforms (E2, E3, E4) and distinguished each of the isoforms by a unique combination of HhaI fragment sizes that enabled unambiguous typing of all homozygotic and heterozygotic combinations.