A pilot study of golexanolone, a new GABA-A receptor-modulating steroid antagonist, in patients with covert hepatic encephalopathy.
Sara Montagnese,Mette Munk Lauridsen,Hendrik Vilstrup,Lisa Zarantonello,Geza Lakner,Sergey Fitilev,Igor A. Zupanets,Irina Kozlova,Elena Bunkova,Krzysztof Tomasiewicz,Jan Erik Berglund,Fredrik Rorsman,Hannes Hagström,Stergios Kechagias,Carin Edmark Ocklind,Joe Mauney,Fredrik Thunarf,Masoud Mokhatarani,Torbjörn Bäckström,Magnus Doverskog,Lars-Erik Lins,Maria Månsson,Per Samuelson,Dag Nilsson,Martin Schalling,Maja Johansson,Eva Arlander,Bruce F. Scharschmidt +27 more
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TLDR
Golexanolone as mentioned in this paper is a small molecule GABA-A receptor modulating steroid antagonist under development for treatment of cognitive and vigilance disorders due to allosteric over-activation of GABA receptors by neurosteroids.About:
This article is published in Journal of Hepatology.The article was published on 2021-03-24 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Epworth Sleepiness Scale.read more
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Journal ArticleDOI
Hepatic encephalopathy
Dieter Häussinger,Radha K. Dhiman,Vicente Felipo,Boris Görg,Rajiv Jalan,Gerald Kircheis,Manuela Merli,Sara Montagnese,Manuel Romero-Gómez,Alfons Schnitzler,Simon D. Taylor-Robinson,Hendrik Vilstrup +11 more
TL;DR: Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease as discussed by the authors , which is the most serious complication of decompensated liver cirrhosis.
Journal ArticleDOI
Hepatic encephalopathy.
Dieter Häussinger,Radha K. Dhiman,Vicente Felipo,Boris Görg,Rajiv Jalan,Gerald Kircheis,Manuela Merli,Sara Montagnese,Manuel Romero-Gómez,Alfons Schnitzler,Simon D. Taylor-Robinson,Hendrik Vilstrup +11 more
TL;DR: Hepatic encephalopathy (HE) is a prognostically relevant neuropsychiatric syndrome that occurs in the course of acute or chronic liver disease as mentioned in this paper , which is the most serious complication of decompensated liver cirrhosis.
Journal ArticleDOI
Sleep and liver disease: a bidirectional relationship.
Thomas Marjot,Thomas Marjot,David W. Ray,Felicity R. Williams,Felicity R. Williams,Jeremy W. Tomlinson,Matthew J. Armstrong +6 more
TL;DR: In this paper, the authors discuss the multiple converging pathways leading to abnormal sleeping patterns in patients with chronic liver disease, including altered melatonin metabolism, neuromuscular complications, and aberrant thermoregulation.
Journal ArticleDOI
The neurogliovascular unit in hepatic encephalopathy.
Wouter Claeys,Lien Van Hoecke,Sander Lefere,Anja Geerts,Xavier Verhelst,Hans Van Vlierberghe,Helena Degroote,Lindsey Devisscher,Roosmarijn E. Vandenbroucke,Christophe Van Steenkiste +9 more
TL;DR: In this paper, a holistic concept of the neurogliovascular unit is used to describe central nervous system disturbances in hepatic encephalopathy, an approach that has proven instrumental in other neurological disorders.
Journal ArticleDOI
Review article: current and emerging therapies for the management of cirrhosis and its complications
TL;DR: Cirrhosis is increasingly common and morbid and optimal utilisation of therapeutic strategies to prevent and control the complications of cirrhosis are central to improving clinical and patient‐reported outcomes.
References
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A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
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Steroid Hormone Metabolites are Barbiturate-Like Modulators of the GABA Receptor
Maria Dorota Majewska,Neil L. Harrison,Rochelle D. Schwartz,Jeffery L. Barker,Steven M. Paul +4 more
TL;DR: Two metabolites of the steroid hormones progesterone and deoxycorticosterone are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons, which may explain the ability of certain steroid hormones to rapidly alter neuronal excitability.
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Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver
Hendrik Vilstrup,Piero Amodio,Jasmohan S. Bajaj,Jasmohan S. Bajaj,Juan Córdoba,Peter Ferenci,Kevin D. Mullen,Karin Weissenborn,Philip Wong +8 more
TL;DR: The AASLD/EASL Practice Guideline Subcommittee on Hepatic Encephalopathy are: Jayant A. Talwalkar, Hari S. Conjeevaram, Michael Porayko, Raphael B. Merriman, Peter L. Jansen, Fabien Zoulim.
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Neuropsychological characterization of hepatic encephalopathy
Journal ArticleDOI
Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients
Piero Amodio,Franco Del Piccolo,Elena Pettenò,Daniela Mapelli,Paolo Angeli,R.M. Iemmolo,Maurizio Muraca,C. Musto,Giorgio Enrico Gerunda,Cristiano Rizzo,Carlo Merkel,Angelo Gatta +11 more
TL;DR: In this article, a series of 296 consecutive cirrhotic patients who had undergone quantified-EEG was studied, and the EEG alterations were detected in 38% of the patients.