Journal ArticleDOI
A positive allosteric modulator of mGluR5 promotes neuroprotective effects in mouse models of Alzheimer's disease.
Paula Maria Quaglio Bellozi,Giovanni Freitas Gomes,Maria Carolina Machado da Silva,Isabel Vieira de Assis Lima,Carla R.A. Batista,Wellerson de Oliveira Carneiro Junior,Juliana G. Doria,Érica Leandro Marciano Vieira,Rafael P. Vieira,Rossimiriam Pereira de Freitas,Cláudia N. Ferreira,Eduardo Candelario-Jalil,Tony Wyss-Coray,Fabiola M. Ribeiro,Antônio Carlos Pinheiro de Oliveira +14 more
TLDR
Despite a four-week treatment did not prevent memory loss in aged transgenic mice, CDPPB possess is protective against Aβ stimulus, therefore, this drug represents a potential candidate for further investigations as AD treatment.About:
This article is published in Neuropharmacology.The article was published on 2019-12-01. It has received 17 citations till now. The article focuses on the topics: CDPPB & Neuroprotection.read more
Citations
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Journal ArticleDOI
Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner.
Khaled S. Abd-Elrahman,Khaled S. Abd-Elrahman,Awatif Albaker,Awatif Albaker,Jessica M. de Souza,Fabiola M. Ribeiro,Michael G. Schlossmacher,Mario Tiberi,Alison Hamilton,Stephen S. G. Ferguson +9 more
TL;DR: The findings suggest that mGluR5 inhibitors may be therapeutically beneficial only for male patients with AD, and suggest the need for sex-specific stratification in clinical trials assessing AD therapeutics.
Journal ArticleDOI
mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent
Khaled S. Abd-Elrahman,Khaled S. Abd-Elrahman,Alison Hamilton,Awatif Albaker,Awatif Albaker,Stephen S. G. Ferguson +5 more
TL;DR: It is found that this loss in CTEP efficacy in 15 month old APPswe/PS1ΔE9 mice was due to the abolished contribution of ZBTB16 and mTOR-mediated signaling to AD neuropathology at this advanced disease stage.
Journal ArticleDOI
Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease
TL;DR: In this article , the authors considered that sex-specific differences in the pharmacology of mGluR5 and activation of noncanonical signaling downstream of the receptor suggest that its utility as a therapeutic target in female AD patients needs to be reconsidered.
Journal ArticleDOI
Deleterious Alteration of Glia in the Brain of Alzheimer’s Disease
TL;DR: The new findings tell us that the neuronal environment in the AD condition is a far more complicated and dynamically interacting space, and the identification of each molecule in the milieu and cellular communication would contribute to a better understanding of AD in the neurobiological perspective, consequently suggesting a possible therapeutic clue.
Journal ArticleDOI
International Union of Basic and Clinical Pharmacology. CXI. Pharmacology, Signaling, and Physiology of Metabotropic Glutamate Receptors
Karen J. Gregory,Cyril Goudet +1 more
TL;DR: Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for higher-order brain functions such as learning and memory.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Book
The Mouse Brain in Stereotaxic Coordinates
TL;DR: The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use and includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material.
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Astrocytes: biology and pathology
TL;DR: Astrocyte functions in healthy CNS, mechanisms and functions of reactive astrogliosis and glial scar formation, and ways in which reactive astrocytes may cause or contribute to specific CNS disorders and lesions are reviewed.
Journal ArticleDOI
Physiology of Microglia
TL;DR: Current studies indicate that even in the normal brain, microglia have highly motile processes by which they scan their territorial domains, and microglial cells are considered the most susceptible sensors of brain pathology.
Journal ArticleDOI
Acetylcholinesterase Inhibitors: Pharmacology and Toxicology
TL;DR: An overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds is presented, with emphasis on oxime reactivators of the inhibited enzyme activity administering as causal drugs after the poisoning.