Journal ArticleDOI
A randomized, double-blind, placebo-controlled trial of porcine versus synthetic secretin for reducing symptoms of autism.
Alan S. Unis,Jeffrey Munson,Sally J. Rogers,Ed Goldson,Julie Osterling,Robin L. Gabriels,Robert D. Abbott,Geraldine Dawson +7 more
Reads0
Chats0
TLDR
No evidence that either biologic or synthetic secretin provided amelioration of symptoms beyond placebo was observed, and this held true when children with and without gastrointestinal problems were examined separately.Abstract:
Objective: To compare the effects of a single dose of biologic and synthetic porcine secretin to placebo on a variety of autism symptoms. Method: Eighty-five children with autism without other medical conditions and not taking other psychotropic medications participated (ages between 3 and 12 years, mean IQ = 55). Children were grouped into trios matched by age and communication level and then randomly assigned to one of three treatment groups: biologic secretin (2 CU/kg), synthetic secretin (0.4 μg/kg), and placebo. Measures collected 1 week before and 4 weeks after infusion included autism symptoms, language skills, and problem behaviors, gathered from parents, teachers, and investigators, who were all blind to treatment. Two-factor, repeated-measures analyses of variance (3 treatment levels by 2 repeated measures, pre- and postinfusion) were used to examine efficacy. Results: Direct observation measures did not show change over time related to secretin. Parent reports showed an overall reduction of symptom severity for all treatment groups, including the placebo group. One teacher-report measure showed decreases in autism symptoms in the placebo and synthetic secretin groups. Conclusions: No evidence that either biologic or synthetic secretin provided amelioration of symptoms beyond placebo was observed. This held true when children with and without gastrointestinal problems were examined separately.read more
Citations
More filters
Book
Autism and Pervasive Developmental Disorders
TL;DR: The quantity and quality of research into autism and related conditions have increased dramatically in recent years as mentioned in this paper, and there has been significant advances in the molecular genetics of autism and understanding of the underlying neurobiological processes.
Journal ArticleDOI
Evidence-Based Comprehensive Treatments for Early Autism
TL;DR: The empirical studies of comprehensive treatments for young children with autism published since 1998 were reviewed and found that most studies were either Type 2 or 3 in terms of their methodological rigor based on Nathan and Gorman's (2002) criteria.
Journal ArticleDOI
Autism and pervasive developmental disorders
TL;DR: Pediatricians are the first health professional to come in contact with patients with autism, Thus, they should be able to diagnose and to coordinate the multidisciplinary treatment of these patients.
Journal ArticleDOI
Autism spectrum disorders: early detection, intervention, education, and psychopharmacological management.
TL;DR: It is concluded from the review of the evidence that, in the absence of additional, more compelling data, the clinical usefulness of existing screening instruments remains questionable.
Journal ArticleDOI
Complementary and Alternative Medicine Treatments for Children with Autism Spectrum Disorders
Susan E. Levy,Susan L. Hyman +1 more
TL;DR: The evidence supporting the most frequently used CAM treatments, including categories of mind-body medicine, energy medicine, and biologically based, manipulative, and body-based practices, are discussed, with the latter two treatments the most commonly selected by families.
References
More filters
Journal ArticleDOI
The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism.
Catherine Lord,Susan Risi,Linda Lambrecht,Edwin H. Cook,Bennett L. Leventhal,Pamela C. DiLavore,Andrew Pickles,Michael Rutter +7 more
TL;DR: Algorithm sensitivities and specificities for autism and PD DNOS relative to nonspectrum disorders were excellent, with moderate differentiation of autism from PDDNOS.
Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TL;DR: In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.
Journal Article
The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects.
TL;DR: The development of a scale to assess drug and other treatment effects on severely mentally retarded individuals was described and the results were compared with empirically derived rating scales of childhood psychopathology and with factor analytic work in the field of mental retardation.
Related Papers (5)
Risperidone in Children with Autism and Serious Behavioral Problems
James T. McCracken,James J. McGough,Bhavik Shah,Pegeen Cronin,Daniel Hong,Michael G. Aman,L. Eugene Arnold,Ronald L. Lindsay,Patricia L. Nash,Jill A. Hollway,Christopher J. McDougle,David J. Posey,Naomi B. Swiezy,Arlene E. Kohn,Lawrence Scahill,Andrés Martin,Kathleen Koenig,Fred R. Volkmar,Deirdre H. Carroll,Allison Lancor,Allison Lancor,Elaine Tierney,Jaswinder K. Ghuman,N. González,Marco A. Grados,Benedetto Vitiello,Louise Ritz,Mark Davies,James Robinson,Donald J. McMahon +29 more