A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering.
Deval Prasad Bhattarai,Ludwig Erik Aguilar,Chan Hee Park,Cheol Sang Kim +3 more
- Vol. 8, Iss: 3, pp 62
TLDR
This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds, and the current development and future perspectives on the use of Electrospun mats inBone tissue engineering.Abstract:
Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.read more
Citations
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Recent advances in biomaterials for 3D scaffolds: A review.
Maria P. Nikolova,Murthy Chavali +1 more
TL;DR: A comprehensive summary of recent trends in development of single- (metal, ceramics and polymers), composite-type and cell-laden scaffolds that in addition to mechanical support, promote simultaneous tissue growth, and deliver different molecules or cells with therapeutic or facilitating regeneration effect is offered.
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Scaffold fabrication technologies and structure/function properties in bone tissue engineering
TL;DR: A comprehensive review of the current accomplishments on scaffold fabrication techniques, their structure, and function properties for BTE is provided and strategies to improve vascularization potential and immunomodulation are presented.
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Current applications of poly(lactic acid) composites in tissue engineering and drug delivery
TL;DR: Recent progress on strategies to address PLA problems is summarized, including novel fabrication techniques, high-performance PLA composites, and their applications for tissue engineering and drug delivery.
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Natural Polymeric Scaffolds in Bone Regeneration
Miriam Filippi,Miriam Filippi,Gordian Born,Mansoor Chaaban,Arnaud Scherberich,Arnaud Scherberich +5 more
TL;DR: An overview of the various types of natural polymers currently adopted in bone tissue engineering is offered, describing their manufacturing techniques and procedures of functionalization with active biomolecules, and listing the advantages and disadvantages in their respective use in order to critically compare their actual applicability potential.
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Recent advances in composites based on cellulose derivatives for biomedical applications.
Madalina Oprea,Stefan Ioan Voicu +1 more
TL;DR: Cellulose derivatives-based composites with improved properties were researched as films and membranes for osseointegration, hemodialysis and biosensors, smart textile fibers, tissue engineering scaffolds, hydrogels and nanoparticles for drug delivery.
References
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A review on polymer nanofibers by electrospinning and their applications in nanocomposites
TL;DR: In this article, a comprehensive review is presented on the researches and developments related to electrospun polymer nanofibers including processing, structure and property characterization, applications, and modeling and simulations.
Journal ArticleDOI
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Jeanie L. Drury,David J. Mooney +1 more
TL;DR: Hydrogels are an appealing scaffold material because they are structurally similar to the extracellular matrix of many tissues, can often be processed under relatively mild conditions, and may be delivered in a minimally invasive manner.
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TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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Silk-based biomaterials
Gregory H. Altman,Frank Diaz,Caroline M. Jakuba,Tara Calabro,Rebecca L. Horan,Jingsong Chen,Helen H. Lu,John C. Richmond,David L. Kaplan +8 more
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