Journal ArticleDOI
A Simple, Efficient and Green Procedure for the Knoevenagel Condensation of Aldehydes with N-Methylpiperazine at Room Temperature under Solvent-Free Conditions
Chhanda Mukhopadhyay,Arup Datta +1 more
TLDR
In this article, Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions.About:
This article is published in Synthetic Communications.The article was published on 2008-08-18. It has received 35 citations till now. The article focuses on the topics: Knoevenagel condensation & Malononitrile.read more
Citations
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Journal ArticleDOI
Homogeneous and Stereoselective Copper(II)-Catalyzed Monohydration of Methylenemalononitriles to 2-Cyanoacrylamides
TL;DR: A facile and efficient route for the homogeneous and highly stereoselective monohydration of substituted methylenemalononitriles to (E)-2-cyanoacrylamides catalyzed by copper(II) acetate monohydrate in acetic acid containing 2% water is described, and a mechanism is proposed.
Journal ArticleDOI
A simple, efficient, and green protocol for Knoevenagel condensation in a cost-effective ionic liquid 2-hydroxyethlammonium formate without a catalyst
TL;DR: In this article, a reusable and cheap ionic liquid 2-hydroxyethylammonium formate was used for condensation of aromatic aldehydes with active methylene compounds such as malononitrile, ethylcyanoacetate, and cyanoacetamide.
Journal ArticleDOI
Facile synthesis of pure non-monoclinic zirconia nanoparticles and their catalytic activity investigations for Knoevenagel condensation
TL;DR: In this paper, TEM observation confirmed that the nanoparticles have an approximately spherical shape with an average size of 3-4 nm and a non-monoclinic structure.
Journal ArticleDOI
The Knoevenagel condensation using quinine as an organocatalyst under solvent-free conditions
TL;DR: The Knoevenagel condensation between active methylene compounds and aromatic carobonyl compounds has been developed using quinine as an organocatalyst to afford various electrophilic alkenes in excellent yields as mentioned in this paper.
Journal ArticleDOI
Cross-linked polystyrene-TiCl4 complex as a reusable Lewis acid catalyst for solvent-free Knoevenagel condensations of 1,3-dicarbonyl compounds with aldehydes
Ali Rahmatpour,Niloofar Goodarzi +1 more
TL;DR: In this paper, a polystyrene copolymer with the average particle size in the range of (50-80 mesh size) was prepared by a new method, characterized and functionalized with titanium tetrachloride.
References
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Journal ArticleDOI
Solvent‐Free Organic Synthesis
Koichi Tanaka,Fumio Toda +1 more
TL;DR: This paper presents a new approach to solvent-free organic synthesis called “Solvent-free synthesis with real-time stoichiometry” that combines high-performance liquid chromatography and high-tech electronics.
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Solvent-free organic synthesis
Koichi Tanaka,Fumio Toda +1 more
TL;DR: In this paper, the authors proposed a Solvent Free Organic Synthesis (SOS) method for organic synthesis, which is a state-of-the-art method for solvent-free organic synthesis.
Journal ArticleDOI
Montmorillonite KSF as an Inorganic, Water Stable, and Reusable Catalyst for the Knoevenagel Synthesis of Coumarin-3-carboxylic Acids.
Journal ArticleDOI
Zinc chloride as a new catalyst for knoevenagel condensation
TL;DR: In this article, the knoevenagel condensation of carbonyl substrates with acidic methylene reagents proceeds smoothly in presence of zinc chloride, without the need for solvent, to produce products of good purity in high yield.
Journal Article
Ionic liquid as catalyst and reaction medium – a simple, efficient and green procedure for Knoevenagel condensation of aliphatic and aromatic carbonyl compounds using a task-specific basic ionic liquid
Brindaban C. Ranu,Ranjan Jana +1 more
TL;DR: In this article, the authors proposed a methodology for condensation of aliphatic aldehyde with diethyl malonate, which is not very easy to achieve by conventional reagents, and was not addressed adequately in literature.
Related Papers (5)
Ionic Liquid as Catalyst and Reaction Medium – A Simple, Efficient and Green Procedure for Knoevenagel Condensation of Aliphatic and Aromatic Carbonyl Compounds Using a Task‐Specific Basic Ionic Liquid
Brindaban C. Ranu,Ranjan Jana +1 more